A5020415321- Bone and Dental Protein Studies
- dental development and anomalies
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Calcium Carbonate Crystallization and Inhibition
- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Bone health and treatments
Suzhou Vocational Health College
2021-2022
Stomatology Hospital
2021-2022
Nanjing Medical University
2017
Rationale: Bone homeostasis is maintained by a balanced interplay of osteoblasts and osteoclasts.Osteoclasts are derived from monocyte/macrophage lineage.Major vault protein (MVP) known to promote apoptosis prevent metabolic diseases in macrophage.However, whether MVP involved osteoclastogenesis unknown.Here, we identified an important function as negative regulator its therapeutic potential preventing bone loss.Methods: Expression osteoclasts was investigated human tumor tissues with...
Orthodontic force-induced osteogenic differentiation and bone formation at tension sites play a critical role in orthodontic tooth movement. However, the molecular mechanism underlying this phenomenon is poorly understood. In current study, we investigated involvement of GSK-3β/β-catenin signaling pathway, which for during We established rat movement model to test hypothesis that force may stimulate site moved promote rate via regulation pathway. Our results showed continued mechanical...
The neural crest is one of the key features craniofacial development. MicroRNA‑1 (miR‑1) a single‑stranded noncoding RNA that serves an important role in embryonic However, function miR‑1 cells (NCCs) unknown. Therefore, to evaluate NCC development, mutant zebrafish was generated current study. Mouse NCCs were isolated from first branchial arch embryos at gestational day E9.5, and silenced using inhibitor. To best our knowledge, present study report homozygous lacking exhibited developmental...
Orthodontic tooth movement mainly depends on biological and mechanical reactions in the periodontium, such as indispensable reconstruction process of periodontal ligament alveolar bone. To explore whether orthodontic compressive force can induce bone resorption during by regulating GSK-3β/β-catenin pathway.We established models Sprague-Dawley rats. In addition, force-induced that occurred was analyzed HE staining micro-CT. The number distribution osteoclasts were observed TRAP staining....