A5008358568- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Electrochemical Analysis and Applications
- Nanocluster Synthesis and Applications
- Chemical Synthesis and Analysis
- Carbon and Quantum Dots Applications
- DNA and Nucleic Acid Chemistry
- Conducting polymers and applications
- Peptidase Inhibition and Analysis
- Molecular Sensors and Ion Detection
- Metal-Organic Frameworks: Synthesis and Applications
- Flame retardant materials and properties
- Fire dynamics and safety research
- Covalent Organic Framework Applications
- Nanoparticle-Based Drug Delivery
- Neuropeptides and Animal Physiology
- Extracellular vesicles in disease
- Quantum Dots Synthesis And Properties
- Lanthanide and Transition Metal Complexes
- Monoclonal and Polyclonal Antibodies Research
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
- Analytical Chemistry and Sensors
Southern Medical University
2016-2025
Ministry of Education of the People's Republic of China
2024
Northwest University
2024
TCM-Intigrated Cancer Center of Southern Medical University
2024
University of Jinan
2014-2024
Changchun University of Science and Technology
2024
Capital Medical University
2020-2024
North China Electric Power University
2012-2023
China Electric Power Research Institute
2023
China Aerospace Science and Industry Corporation (China)
2023
In response to a meal, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released modulate glycemic control. Normally these incretins rapidly degraded by dipeptidyl peptidase-4 (DPP-4). DPP-4 inhibitors novel class of oral antihyperglycemic agents in development for the treatment type 2 diabetes. The degree inhibition level active incretin augmentation required glucose lowering efficacy after an tolerance test (OGTT) were evaluated.The objective study was...
This review summarized the recent progress in synthesis, characterization, properties, photoluminescence mechanism and biological applications of carbon dots.
Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes two-way enhancement of ICD based on CaO2 @CuS-MnO2 @HA (CCMH) nanocomposite to overcome the insufficient damage-associated molecular patterns (DAMPs) conventional ICD-inducers. The near-infrared (NIR) irradiation (1064 nm) CuS nanoparticles generates 1 O2 through photodynamic therapy (PDT) trigger ICD, also damages Ca2+ buffer...
Abstract Nanozyme‐based chemodynamic therapy (CDT) has emerged as an effective cancer treatment because of its low side effects and without the requirement exogenous energy. The therapeutic effect CDT highlights pivotal importance active sites, H 2 O supplement glutathione (GSH) depletion a nanozyme. construction single kind catalyst with multiple functions for enhanced is still big challenge. In this work, seven types bimetallic nanoparticles are synthesized using metal–organic framework...
Chemodynamic therapy (CDT) can effectively induce immunogenic cell death (ICD) in tumours and is thus a promising strategy for boosting the efficacy of immunotherapy. However, mechanism by which CDT enhances ICD lowers efficiency unknown this restricts its clinical application. In study, second near-infrared (NIR-II) window irradiation-triggered hydrogen peroxide (H2O2) self-supplying nanocomposite ((Cu2Se-CaO2)@LA) was constructed. The modified lauric acid melted heat energy NIR-II...
Cerebrospinal fluid (CSF) biomarkers are more sensitive than the Movement Disorder Society (MDS) criteria for detecting prodromal Parkinson's disease (PD). Early detection of PD provides best chance successful implementation disease-modifying treatments, making it crucial to effectively identify CSF extracted from patients or normal individuals. In this study, an intelligent sensor array was built by using three metal–organic frameworks (MOFs) that exhibited varying catalytic kinetics after...
Near-infrared (NIR) quantum dots (QDs) have emerged as an attractive bioimaging toolkit for exploring biological events because they can provide deep imaging penetration and low fluorescence background. However, the quantitation process of such NIR QDs generally relies on single-emission intensity change, which is susceptible to a variety environmental factors. Herein, first time, we proposed protein-directed co-template strategy synthesize NIR-based, dual-emission fluorescent nanohybrid...
Abstract The selection of DNA‐encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement modified immobilized remains a significant disadvantage. With terminal protection strategy ligand‐induced photo‐crosslinking, we show that iterated selections can be realized with unmodified non‐immobilized protein targets.
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that so far incurable with long-term health risks. The high doses frequent administration for the available RA drug always lead to adverse side effects. Aiming at obstacles achieving effective treatment, we prepared macrophage cell membrane-camouflaged nanoparticles (M-EC), which were assembled from epigallocatechin gallate (EGCG) cerium(IV) ions. Due its geometrical similarity active metal sites of a natural antioxidant...
Oxidative stress due to Cu2+-triggered aggregation of β-amyloid protein (Aβ) and reactive oxygen species (ROS) overexpression in the brain is an important hallmark early stages Alzheimer's disease (AD) pathogenesis. The ideal modulator for improving oxidative microenvironment AD brains should take both Cu2+ ROS into consideration, which has been rarely reported. Here, a combined therapeutic strategy was achieved by co-encapsulating superoxide dismutase (SOD) catalase (CAT) imine-linked...
Amino acids (AAs) are abundant in nature as the basic constituent unit of waste proteins. acid protic ionic liquids (AA-PILs) rich C, N, O, and S elements can be easily synthesized, making them a promising potential precursor N/S codoped carbon materials for high-performance supercapacitors. A series 21 AA-PILs were prepared directly carbonized with various yields due to different alkyl group AA-PILs, indicating that yield aromatic was much higher than aliphatic heterocyclic AA-PILs. To...
Integrating multiple components of a logic device into 3D DNA nanoprism provides universal platform for constructing diverse gates.
To enhance the fire safety of epoxy resins (EP) without affecting other properties, a novel organophosphorus compound named DDPPM has been synthesized and used as co-curing agent to obtain inherent flame-retardant EP. The Fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance (1H NMR), 31P (31P NMR) proven successful synthesis DDPPM. mechanical results demonstrated that properties resin did not deteriorate after adding DDPPM, differential scanning calorimetry (DSC)...
Patients with triple-negative breast cancer (TNBC) have dismal prognoses due to the lack of therapeutic targets and susceptibility lymph node (LN) metastasis. Therefore, it is essential develop more effective approaches identify early TNBC tissues LNs. In this work, a magnetic resonance imaging (MRI) contrast agent (Mn-iCOF) was constructed based on Mn(II)-chelated ionic covalent organic framework (iCOF). Because porous structure hydrophilicity, Mn-iCOF has high longitudinal relaxivity (r1)...
Abstract Implant‐associated osteomyelitis (IAOM) is characterized by bone infection and destruction; current therapy of antibiotic treatment surgical debridement often results in drug resistance defect. It challenging to develop an antibiotic‐free bactericidal osteogenic‐enhanced strategy for IAOM. Herein, IAOM‐tailored antibacterial osteoinductive composite copper (Cu)–strontium (Sr) peroxide nanoparticles (CSp NPs), encapsulated polyethylene glycol diacrylate (PEGDA) (CSp@PEGDA), designed....