A5075909334- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Video Surveillance and Tracking Methods
- Extracellular vesicles in disease
- Evacuation and Crowd Dynamics
- Building Energy and Comfort Optimization
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- Automated Road and Building Extraction
- RNA modifications and cancer
- Design Education and Practice
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and disorders
- Genetic and phenotypic traits in livestock
- Recommender Systems and Techniques
- Animal Nutrition and Physiology
- Livestock and Poultry Management
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
Animal Science Research Institute
2024
Peking University Shenzhen Hospital
2021-2024
Hong Kong University of Science and Technology
2021-2024
University of Hong Kong
2021-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Chengdu University
2024
Sichuan University
2024
University of South China
2020-2024
Jiangxi Academy of Agricultural Sciences
2024
Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes two-way enhancement of ICD based on CaO2 @CuS-MnO2 @HA (CCMH) nanocomposite to overcome the insufficient damage-associated molecular patterns (DAMPs) conventional ICD-inducers. The near-infrared (NIR) irradiation (1064 nm) CuS nanoparticles generates 1 O2 through photodynamic therapy (PDT) trigger ICD, also damages Ca2+ buffer...
Efficient hepatocellular carcinoma (HCC) treatment remains a significant challenge due to the inherent limitations of traditional strategies. The exploration polysaccharides' natural immunity for HCC immunotherapy is rarely explored. For this purpose, facile construction multifunctional nanoplatform, biotinylated aldehyde alginate-doxorubicin nano micelle (BEACNDOXM) reported in study synergistic chemo-immunotherapy by using constant β-D-mannuronic acid (M) units and modulated...
In the wave of digital transformation, secure flow information and data authenticity verification have become vital challenges. This paper proposes an innovative model based on blockchain technology to build efficient, transparent immutable environment. The uses distributed ledger characteristics guarantee integrity introduces advanced identity management mechanisms trust algorithms enhance security in process. then improved consensus algorithm, combined with contract technology, ensure...
Efficient hepatocellular carcinoma (HCC) therapy remains a significant challenge due to the unsatisfactory targeting efficiency of nanoparticles (NPs) with either passive or single active property. Although dual-targeting mechanism-based strategy can promote partial efficiency, most reported NPs properties generally suffer from sophisticated chemical design, multistep synthesis, and purification procedures, leading batch-to-batch variation difficulties in scalable production. To develop...
Clinical treatment of advanced hepatocellular carcinoma (HCC) remains a significant challenge. Utilizing 1-bromoacetyl-3,3-dinitroazetidine (RRx-001) to downregulate the expression innate immune checkpoint molecule, cluster differentiation 47 (CD47), provides powerful means for treating HCC containing abundant immunosuppressive macrophages. Herein engineering previously optimized Doxorubicin (DOX)-delivery nanoplatform based on sodium alginate is reported further co-deliver RRx-001...
Abstract Hydroxyapatite nanoparticles (HAP) have been widely used in various fields because of their natural biological origin and functional properties. The emerging evidence on toxicities has attracted research interest. HAP-induced vascular smooth muscle cell (VSMC) damage is a key step calcification (VC), particularly patients with chronic kidney disease. However, the injury effects mechanism action HAP VSMCs not extensively investigated. This study comprehensively characterized...
The present study aimed to investigate the biological function and relative mechanisms of circRNA_100876 in gastric cancer (GC). To this end, quantitative real-time polymerase chain reaction (RT-qPCR) was performed examine expression miR-665 GC tissues cells, depleted by transfection circ_100876-targeting siRNAs. CCK-8, flow cytometry, Transwell assays were applied cell cycle distribution, proliferation, apoptosis, migration, invasion abilities. Proteins related apoptosis...
Although the local high quality chicken breed in China has excellent flavor, its growth rate is inferior to that of foreign breeds. To improve breeds, it crucial study mechanism muscle development. Herein, Ningdu Yellow was used as research object, and a new hybrid (W) obtained by crossing G, H D lines, which combined physiological characteristics parents. Combined analysis chickens their parents carried out. Chickens from 105-day-old lines (W, H) were selected, breast meat serum extracted...
Background Non-alcoholic fatty liver disease (NAFLD) and ulcerative colitis (UC) are two common health issues that have gained significant global attention. Previous studies suggested a possible connection between NAFLD UC, but the underlying pathophysiology remains unclear. This study investigates genes, pathogenesis mechanisms, identification of diagnostic markers applicable to both conditions, exploration potential therapeutic targets shared by UC. Methods We obtained datasets for UC from...
Objective: Dermoscopic features of cutaneous vascular anomalies have been reported, but the described currently known are limited and not well-understood. The aim this study is to comprehensively summarize compare dermoscopic four different types [infantile hemangiomas (IH), cherry angioma (CA), angiokeratomas (AK), pyogenic granuloma (PG)] in Chinese Han population. Materials Methods: 31 IH, 172 CA, AK, 45 PG were collected based on contact non-polarized mode dermoscopy at 20-fold...
Recent evidence has indicated that circular RNAs (circRNAs), a novel type of regulatory RNA, play important roles in the development and progression various cancers. However, potential molecular mechanisms circRNAs clear cell renal carcinoma (ccRCC) remain largely unclear. Here, we explored circRNA expression profiles 10 paired samples RCC (including cancer tissues surrounding tissues) from Gene Expression Omnibus (GEO) datasets GSE124453 GSE108735. We initially identified hsa_circ_0086457,...
Abstract The size and condition of the peripheral CD4 T cell population determine capacity immune response. Under homeostatic conditions, is maintained through turnover survival. However, underlying mechanisms remain inadequately understood. Here, we observed a significant decrease in percentage cells periphery following targeted deletion Paxbp1 gene mouse cells. In absence Paxbp1, naïve displayed reduced surface interleukin‐7 receptor levels decreased to respond survival signals mediated by...
Comparative study on the immunologic functions of total flavones Epimedium (TFE) in two species Guizhou CTX mice.To set up a hypoimmunity mouse model by and give TFE 10 days, enhancement were observed with indice weight body spleen, spleen-index, serum level hemolysin, TNF-alpha IL-2.The IL-2 mice decreased apparently (P < 0.01) single ip 80 mg x kg(-1). The spleen-index increased, hemolysin increased significantly 0.01), 1.3, 0.65 g kg(-1) from ig.The have an obvious immune effect...
This research utilized a combination of gene databases associated with ferroptosis and online expression data from ischemic stroke samples to pinpoint ferroptosis-related genes (FRGs) in cases. By employing Random Forest (RF) Support Vector Machine (SVM) models based on these genes, an overlap both was identified as "Hub" genes. Through consensus clustering analysis using Hub two distinct clusters FRGs were revealed samples. Examination the correlation between molecular subtypes immune...