A5054039263- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Bone fractures and treatments
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Hip and Femur Fractures
- Shoulder Injury and Treatment
- RNA Research and Splicing
- Circular RNAs in diseases
- Shoulder and Clavicle Injuries
- Renal cell carcinoma treatment
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Porphyrin Metabolism and Disorders
- Ubiquitin and proteasome pathways
- Urinary and Genital Oncology Studies
- Renal and related cancers
- NF-κB Signaling Pathways
- Estrogen and related hormone effects
- Organic Light-Emitting Diodes Research
Ruijin Hospital
2011-2025
Shanghai Jiao Tong University
2011-2024
Sun Yat-sen University
2024
Dalian Medical University
2016-2023
Second Affiliated Hospital of Dalian Medical University
2016-2023
Houston Methodist
2021-2023
Beijing Institute of Nanoenergy and Nanosystems
2023
Chinese Academy of Sciences
2023
Lanzhou University
2023
Weifang People's Hospital
2009-2022
Long non-coding RNAs (lncRNAs) play a pivotal role in tumorigenesis, exemplified by the recent finding that lncRNA maternally expressed gene 3 (MEG3) inhibits tumor growth p53-dependent manner. Acute myeloid leukemia (AML) is most common malignant disorder adults, and TP53 mutations or loss are frequently detected patients with therapy-related AML complex karyotype. Here, we reveal MEG3 significantly downregulated suppresses leukemogenesis not only p53-dependent, but also p53-independent In...
Two polymorphs of the same Dy(III) complex show distinct slow magnetic relaxation behaviors due to different local environments in crystal. This work represents first example where dynamic property neutral rare earth complexes could be tuned by growing polymorphic crystals without changing ligand.
Two new enantiomeric ionic chiral dysprosium(III) compounds were designed and synthesized. These show simultaneously the optical activity, ferroelectric effects, nonlinear-optical slow magnetic relaxation behavior. More interestingly, these exhibit reversible single-crystal-to-single-crystal transformations associated with release or absorption of solvent molecules. The structure are accompanied by distinct changes in physical properties.
Long non-coding RNAs (lncRNAs) function as oncogenes or tumor suppressors, and are involved in mediating tumorigenesis resistance to chemotherapy by altering the expression of genes at various levels. Accumulating evidence suggests that maternally expressed gene 3 (MEG3) lncRNA serves an important role a number cancers. However, its functional cisplatin‑induced apoptosis glioma cells is unknown. To investigate MEG3, mRNA levels MEG3 under cisplatin treatment were investigated reverse...
The dismal prognosis of patients with glioma is largely attributed to cancer stem cells that display pivotal roles in tumour initiation, progression, metastasis, resistance therapy, and relapse. Therefore, understanding how these populations maintain their stem-like properties critical developing effective therapeutics.RNA sequencing analysis was used identify genes potentially involved regulating (GSCs). Integrin β4 (ITGB4) expression validated by quantitative real-time PCR (qRT-PCR)...
To investigate the correlation between serum sex hormone levels and clear cell renal carcinoma(ccRCC). The clinical data of male patients diagnosed with ccRCC simple cysts in our hospital from 2017 to 2023 were collected. basic levels, including luteinizing (LH), follicle stimulating (FSH), estradiol(E2), prolactin (PRL), progesterone(P), testosterone (T), compared cysts. A total 56 82 cyst included study. There was no significant difference age, height, weight, BMI, LH, PRL, P T cyst. E2...
Abstract Salts that contain radical cations of benzidine (BZ), 3,3′,5,5′‐tetramethylbenzidine (TMB), 2,2′,6,6′‐tetraisopropylbenzidine (TPB), and 4,4′‐terphenyldiamine (DATP) have been isolated with weakly coordinating anions [Al(OR F ) 4 ] − (OR =OC(CF 3 or SbF 6 . They were prepared by reaction the respective silver(I) salts stoichiometric amounts its alkyl‐substituted derivatives in CH 2 Cl The characterized UV absorption EPR spectroscopy as well their single‐crystal X‐ray structures....
Abstract Background Adaptation to ER stress has been indicated play an important role in resistance therapy human melanoma. However, the relationship between adaptation and cell metastasis melanoma remains unclear. Methods The of was investigated using transwell mouse assays. potential molecular mechanism KLF4 regulating RNA sequencing analysis, q-RT-PCR western blot transcriptional regulation nucleobindin 2 (NUCB2) by identified bioinformatic luciferase assay, chromatin immunoprecipitation...
We herein introduce a staged management protocol for AO/OTA type 43-C3.3 pilon fractures based on the four-column theory designed to protect soft tissue.Twenty-three patients with 25 C3.3 underwent procedure osteosynthesis from April 2014 December 2016. The first stage involved immediate calcaneal traction or external fixation span ankle joint. When tissue swelling decreased, posterolateral approach was used restore lateral column and initially fix posterior column. After 10 12 days, third...
The abnormal elevation of sulfiredoxin (Srx/SRXN1)—an antioxidant enzyme whose main function is to protect against oxidative stress—has been shown be closely correlated with the progression several types cancer, including human cervical cancer. However, molecular mechanism by which Srx promotes tumor progression, especially cancer metastasis in has not elucidated. Here, we show that expression gradually increases during and its level lymph node metastasis. Our study also reveals a...
Proximal humeral fractures (PHFs) are the third most commonly occurring in elderly patients. Most of these can be treated with conservative methods, but optimal surgical treatment strategy for unstable patients remains controversial. This study aimed to compare radiological and clinical outcomes between locking compression plate (LCP) fixation LCP fibular allograft implantation comminuted PHFs.We retrospectively reviewed 60 (mean age, 72.75 years) closed 3- or 4-part fractures, a minimum 2...
Abstract Isoalantolactone (IATL), a sesquiterpene lactone compound, possesses many pharmacological and biological activities, but its role in glioblastoma (GBM) treatment is still unknown. The aim of the current study was to investigate antiglioma effects IATL explore underlying molecular mechanisms. In study, functions were examined by MTT, cell migration, colony formation, apoptosis assays. Confocal immunofluorescence techniques, chromatin immunoprecipitation, pull‐down assays used precise...
// Dekang Lv 1, * , Xiang Wang Jun Dong 1 Yan Zhuang Shuyu Huang Binbin Ma 2 Puxiang Chen 3 Xiaodong Li Bo Zhang Zhiguang Bilian Jin Institute of Cancer Stem Cell, Center, Dalian Medical University, Dalian, 116044, Liaoning, P.R. China Department Neurosurgery, The Second Hospital 116023, Obstetrics and Gynecology, Xiangya Central South Changsha, 410011, Hunan, These authors have contributed equally to this work Correspondence to: Wang, e-mail: wangx6281@dmu.edu.cn Li, zhiguangli@dmu.edu.cn...
The laminin subunit alpha 2 (LAMA2) gene encodes an chain, which constitutes one of the subunits (merosin) and 4 (s-merosin). In current study, we investigated relationship between LAMA2 promoter methylation status invasiveness clinically nonfunctioning pituitary adenomas (PitNETs). Specimens from patients with PitNET were classified into three groups according to preoperative computed tomography (CT)/magnetic resonance imaging findings: a normal group ( n = 6), non-invasive 11) invasive 6)....
The proneural (PN) and mesenchymal (MES) subtypes of glioblastoma multiforme (GBM) are robust generally consistent with classification schemes. GBMs in the MES subclass predominantly primary tumors that, compared to PN tumors, exhibit a worse prognosis; thus, understanding mechanism differentiation may be great benefit for treatment GBM. NF-κB signaling is critically important GBM, activation could induce transdifferentiation which warrants additional research. NUDT21 newly discovered...