A5002821698- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- PI3K/AKT/mTOR signaling in cancer
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Biotin and Related Studies
- Pituitary Gland Disorders and Treatments
- Cell Adhesion Molecules Research
- Peroxisome Proliferator-Activated Receptors
Dalian Medical University
2019-2024
Second Affiliated Hospital of Dalian Medical University
2019-2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Shanghai Institute of Hematology
2023
Inactivation of the tumor suppressor p53 is critical for pathogenesis glioma, in particular glioblastoma multiforme (GBM). MDM2, main negative regulator p53, binds to and forms a stable complex with regulate its activity. Hitherto, it unclear whether stability p53/MDM2 affected by lncRNAs, circular RNAs that are usually abundant conserved, frequently implicated different oncogenic processes.RIP-seq RIP-qPCR assays were performed determine most enriched lncRNAs (including RNAs) bound followed...
The laminin subunit alpha 2 (LAMA2) gene encodes an chain, which constitutes one of the subunits (merosin) and 4 (s-merosin). In current study, we investigated relationship between LAMA2 promoter methylation status invasiveness clinically nonfunctioning pituitary adenomas (PitNETs). Specimens from patients with PitNET were classified into three groups according to preoperative computed tomography (CT)/magnetic resonance imaging findings: a normal group ( n = 6), non-invasive 11) invasive 6)....
Abstract Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding activation, and facilitating amplification of signal transduction across the cellular membrane. However, cell-surface antigen-induced multimerization (dubbed AIM herein) has not yet been consciously leveraged in chimeric antigen (CAR) engineering enriching T cell-based therapies. We co-developed ciltacabtagene autoleucel (cilta-cel), whose CAR...
The development of tyrosine kinase inhibitors (TKIs) has revolutionarily increased the overall survival patients with chronic myeloid leukemia (CML). However, drug resistance remains a major obstacle. Here, we demonstrated that BCR-ABL1-independent long non-coding RNA,
Abstract The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Though an altered microenvironment is general cancer hallmark, whether how APL blasts shape their plasma poorly understood. Here we reported cross-sectional correlation network framework that was successfully applied to interpret multi-layered datasets on clinical laboratory tests, proteomes,...