A5101706597- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Urinary Bladder and Prostate Research
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Sexual function and dysfunction studies
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Urologic and reproductive health conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
- Hair Growth and Disorders
- Histone Deacetylase Inhibitors Research
- Hepatocellular Carcinoma Treatment and Prognosis
- interferon and immune responses
- Maternal and fetal healthcare
- Redox biology and oxidative stress
- Planarian Biology and Electrostimulation
Anhui Medical University
2016-2025
Beijing Hospital of Traditional Chinese Medicine
2025
Capital Medical University
2022-2025
Indiana University Bloomington
2024-2025
First Affiliated Hospital of Anhui Medical University
2019-2024
Eastern Hepatobiliary Surgery Hospital
2021-2024
Second Military Medical University
2021-2024
Shenzhen Second People's Hospital
2016-2024
Shanghai Cancer Institute
2024
Wuhan University
2022
Meat products are an important part in our daily diet, providing valuable nutrients for the human body. However, heating processes cause meat to become more appetizing with changes texture, appearance, flavor, and chemical properties by altering of protein structure other ingredients. As one kind cooking-induced contaminants, heterocyclic aromatic amines (HAAs) widely present aceous food strong carcinogenic mutagenic properties. In order promote safety traditional products, this review...
Hair follicles (HF) undergo precisely regulated recurrent cycles of growth, cessation, and rest. The transitions from anagen (growth), to catagen (regression), telogen (rest) involve a physiological involution the HF. This process is likely coordinated by variety mechanisms including apoptosis loss growth factor signaling. However, precise molecular underlying follicle after hair keratinocyte differentiation shaft assembly remain poorly understood. Here we demonstrate that highly conserved...
Abstract Purpose Prostatitis is a highly prevalent condition that seriously affects men’s physical and mental health. Although epidemiological investigations have provided evidence of correlation between insufficient sleep prostatitis, the pathogenesis prostatitis remains unclear. We sought to identify underlying mechanism involved promising therapeutic target. Methods Sleep deprivation (SD) was utilized establish mouse model in special device. observed at different time points post-SD. The...
The prevalence of brain metastases (BM) in lung cancer patients is notably high and associated with poor prognoses. efficacy standard treatment regimens improving intracranial progression-free survival (IPFS) for BM markedly limited. While traditional Chinese medicine (TCM) has been effective enhancing the quality life prognosis patients, its treating remains unreported. Here, we present a case middle-aged female BM, whose condition was assessed as progressive post-standard including two...
To identify the effectiveness and safety induction using a double-balloon catheter in setting of Coronavirus disease 2019 (COVID−19) infection. This retrospective study included 577 COVID−19-afected women who underwent labor with double balloon or spontaneously started delivery between December 7, 2022, June 20, 2023; 154 (double catheter, group) 423 spontaneous (control group). Maternal neonatal outcomes complications during were assessed compared. Duration first stage total group...
The therapeutic effects of atorvastatin on early brain injury (EBI), cerebral edema and its association with aquaporin 4 (AQP4) were studied in rabbits after subarachnoid hemorrhage (SAH) using western blot analysis the dry-wet method. Seventy-two healthy male New Zealand weighing between 2.5 3.2 kg randomly divided into three groups: SAH group (n=24), sham-operated (n=24) + (n=24). A double model was employed. injected same dose saline solution, received 20 mg/kg/day SAH. All rabbit samples...
Abstract Netrin‐1 ( NTN ‐1) is a novel drug to alleviate early brain injury following subarachnoid haemorrhage SAH ). However the molecular mechanism of ‐1‐mediated protection against remains largely elusive. This study aims evaluate effects and mechanisms ‐1 in protecting ‐induced injury. The endovascular perforation model was constructed using male C57 BL /6J mice, recombinant administrated intravenously. Mortality rates, grade, water content, neurological score neuronal apoptosis were...
Endometrial cancer (EC) is the most prevalent gynecological malignancy, with a higher risk in obese woman, indicating possibility of gut microbiota involvement EC progression. However, no direct evidence relationship between and humans has been discovered. Here, we performed 16S rRNA sequencing to explore dysbiosis development different types patients. The results clearly show differential profiles patients normal participants as well association Targeted metabolomics plasma revealed an...
Abstract Cumulative evidence suggests that abnormal differentiation of T lymphocytes influences the pathogenesis chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Thus, understanding immune activation landscape CP/CPPS would be helpful for improving therapeutic strategies. Here, we utilized BD™ AbSeq to digitally quantify both protein and mRNA expression levels in single peripheral blood cells from two patients healthy controls. We an integrated strategy based on canonical...
Abstract Background To evaluate the relationship between coronavirus disease 2019 (COVID-19) infection at different time points during pregnancy and perinatal outcomes. Methods This retrospective study included 611 women who hospitalized for delivery December 7 April 30, 2023. Based on weeks infected with COVID-19, participants were divided into four groups: Group 1 (14–27 +6 gestation), 2 (28–36 3 (37–39 4 (≥ 40 gestation). Data including maternal demographic characteristics, clinical...
Background: Besides the well-established risk factors for gastric adenocarcinoma (GaC), many other etiological remain largely unexplored. This large comprehensive case-control study aimed to investigate preventable lifestyle and eating habits associated with GaC. Methods: Consecutive patients primary microscopically-confirmed GaC diagnosed in 2016-2018 were matched by sex, age, height, socioeconomic status at a 1:1 ratio healthy controls. Association of versus control investigated was...
Acetyl-CoA carboxylase (ACC) plays an important role in the metabolism of various cancer cells, but its head and neck squamous cell carcinoma (HNSCC) is uncertain. Therefore, present study, we explored ACC2 HNSCC. Western blot immunohistochemistry assays were used to determine protein expression levels laryngocarcinoma adjacent normal tissues derived from patients with laryngocarcinoma. was knocked down hypopharyngeal line FaDu effect on apoptosis. Lipid oil red staining test change...
Abstract Prostate cancer (PCa) is the most frequent malignancy in male urogenital system around worldwide. We performed molecular subtyping and prognostic assessment based on consensus genes patients with PCa. Five cohorts containing 1,046 PCa RNA expression profiles recorded clinical follow-up information were included. Univariate, multivariate Cox regression analysis least absolute shrinkage selection operator (LASSO) used to select establish signature. Immunohistochemistry staining, cell...
Background Prostate cancer (PCa) was one of the most common malignancies among men, while prognosis for PCa patients poor, especially with recurrent and advanced diseases. Materials methods Five cohorts were downloaded from The Cancer Genome Atlas Gene Expression Omnibus databases, biochemical recurrence (BCR)-related chemokine genes identified by LASSO-Cox regression. chemokine-related prognostic gene signature (CRPGS) established, its association patients’ clinical, pathological immune...
Substantial research has revealed that peroxisome proliferator-activated receptor-gamma (PPARG) plays a critical role in glucose homeostasis and lipid metabolism, recent studies have shown different effects the progression of tumors. However, PPARG its target gene clear cell renal carcinoma (ccRCC) are incompletely understood. Clinical data abnormal glucolipid metabolism primary ccRCC samples. In addition, transcriptional profiling indicated expression was positively correlated, whereas Six2...