A5101795472- RNA Research and Splicing
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Wound Healing and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Peroxisome Proliferator-Activated Receptors
- Metallurgical Processes and Thermodynamics
- 3D Printing in Biomedical Research
- Acute Kidney Injury Research
- Macrophage Migration Inhibitory Factor
- Molecular Biology Techniques and Applications
- Solidification and crystal growth phenomena
- Helicobacter pylori-related gastroenterology studies
- Rheology and Fluid Dynamics Studies
- Plant Gene Expression Analysis
- Genetic and Kidney Cyst Diseases
- Physiological and biochemical adaptations
- PI3K/AKT/mTOR signaling in cancer
- Electrospun Nanofibers in Biomedical Applications
- Human-Automation Interaction and Safety
- Iron and Steelmaking Processes
- Antimicrobial Peptides and Activities
City University of Hong Kong
2021-2025
City University of Hong Kong, Shenzhen Research Institute
2025
Zhejiang Sci-Tech University
2023-2024
Harbin Institute of Technology
2024
Second People’s Hospital of Yibin
2024
Sichuan Agricultural University
2023
Chongqing Medical University
2016-2022
Tongling University
2022
Donghua University
2022
Children's Hospital of Chongqing Medical University
2019-2022
Abstract Background and Aim Fexuprazan is a novel potassium‐competitive acid blocker (P‐CAB). This study aimed to explore the noninferior efficacy safety of fexuprazan esomeprazole in treating erosive esophagitis (EE). Methods was phase III, randomized, double‐blind multicenter study. Patients with endoscopically confirmed EE were randomized receive 40 mg or once daily for 4–8 weeks. The healing rates EE, symptom response, GERD‐health‐related quality life (GERD‐HRQL), treatment‐emergent...
Abstract Background The triple-negative subtype of breast cancer is particularly challenging to treat due its aggressiveness with a high risk brain metastasis, and the lack effective targeted therapies. Tubulin beta 2B class IIb (TUBB2B), β-tubulin isoform regulating axon guidance during embryonic development, was found be overexpressed in various types cancers including (TNBC). However, functional roles or metastasis remain unclear. Methods To identify TUBB2B as novel molecular target TNBC,...
BackgroundThe renal tubules, which have distant metabolic features and functions in different segments, reabsorb >99% of approximately 180 l water 25,000 mmol Na + daily. Defective metabolism tubules is involved the pathobiology kidney diseases. However, mechanisms underlying regulation remain to be defined.MethodsWe quantitatively compared proteomes isolated proximal (PT) distal (DT) from C57BL/6 mouse using tandem mass tag (TMT) labeling-based quantitative spectrometry. Bioinformatics...
Triple-negative breast cancer (TNBC) is an aggressive subtype of with poor prognosis. By performing multiomic profiling, we recently uncovered super-enhancer heterogeneity between subtypes. Our data also revealed TCOF1 as a putative TNBC-specific super-enhancer-regulated gene. plays critical role in craniofacial development but its function remains unclear.Overall survival and multivariant Cox regression analyses were conducted using the METABRIC set. The effect knockout on TNBC growth...
Substantial research has revealed that peroxisome proliferator-activated receptor-gamma (PPARG) plays a critical role in glucose homeostasis and lipid metabolism, recent studies have shown different effects the progression of tumors. However, PPARG its target gene clear cell renal carcinoma (ccRCC) are incompletely understood. Clinical data abnormal glucolipid metabolism primary ccRCC samples. In addition, transcriptional profiling indicated expression was positively correlated, whereas Six2...
Mesangioproliferative glomerulonephritis (MsPGN) is a common human kidney disease. Rat Thy-1 nephritis (Thy-1N) an animal model widely used for the study of MsPGN. Thy-1N not only sublytic C5b-9-dependent, but also related to pro-inflammatory cytokine production and macrophage (Mφ) accumulation in rat renal tissues. In this study, we found that expression or phosphorylation chemokine CCL3/4, CD68 (Mφ marker), IRF-8, PKC-α NF-κB-p65 (p65) were all up-regulated both tissues rats (in vivo)...
The treatment of large bone defects remains challenging due to the lack spatiotemporal management immune microenvironment, inflammation response and remodeling. To address these issues, we designed developed a nanoparticle/hydrogel hybrid system that can achieve combined sequential delivery an anti-inflammatory factor (IL-10) osteogenic drug (icariin, ICA). A photopolymerizable composite hydrogel was prepared by combining gelatin methacryloyl (GelMA) heparin-based acrylated hyaluronic acid...
A1CF (apobec-1 complementation factor) acts as a component of the apolipoprotein-B messenger RNA editing complex. Previous researches mainly focused on its post-transcriptional cytidine to uridine editing. However, few study reported role in progression breast carcinoma cells. Wound healing assay and flow cytometry were applied detect migration apoptosis; western blot, real-time polymerase chain reaction, dual-luciferase assays investigate potential regulation mechanism A1CF-mediated cell...
PPP3CB belongs to the phosphoprotein phosphatases (PPPs) group. Although majority of PPP family play important roles in epithelial-to-mesenchymal transition (EMT) tumor cells, little is known about function EMT process. Here, we found had high expression kidney mesenchymal-like cells compared with epithelial-like cells. Knock-down downregulated epithelial marker E-cadherin and upregulated mesenchymal Vimentin, promoting cell states from reorganizing actin cytoskeleton which contributed...
The damage of proximal tubular epithelial cells (PTECs) is considered a central event in the pathogenesis chronic kidney disease (CKD) and deregulated repair processes PTECs result epithelial-mesenchymal transition (EMT), which turn aggravates injury fibrosis. In this study, we firstly revealed that reduction TTC36 associated with unilateral ureteral obstruction (UUO)-induced CKD; besides, ablation attenuated subsequent EMT UUO-treated mice kidneys. Consistently, overexpression promoted...
Abstract Scrap melting in the steelmaking process has recently attracted considerable attention. This study developed a mathematical model to investigate effects of sizes, initial temperatures and carbon contents scrap, bath flow on its behaviors. The results showed that volume solidified shell interface could be decreased or eliminated by increasing temperature scrap. content also significantly influenced behavior. completion time from 253 80 s when increased 0.10% 0.30%. Importantly,...
The PI3K/Akt pathway is frequently deregulated in human cancers, and multiple Akt inhibitors are currently under clinical evaluation. Based on the experience from other molecular targeted therapies, however, it likely that acquired resistance will be developed patients treated with inhibitors. We established breast cancer models of by prolonged treatment cells allosteric or ATP-competitive Phospho-Receptor tyrosine kinase (Phospho-RTK) arrays revealed hyper-phosphorylation RTKS, including...
The wound healing in the presence of bacterial infections is a complex process and prolonged challenge with severe implications for human health. To address this issue, injectable thermo-sensitive hydrogels as dressings have garnered considerable attention potential solution. In study, we developed an antibacterial thermosensitive hydrogel healing, based on chitosan (CS) β -glycerophosphate ( -GP) modified range cinnamaldehyde (CA). CS/ -GP/CA gels demonstrate phase transition at body...
This study aims to investigate the control mechanisms of unsteady Dielectric Barrier Discharge (DBD) plasma excitation on flow separation turbine blades and vortex shedding at trailing edge, as well impact frequency effectiveness. a Large Eddy Simulation (LES) was carried out for T106A analyze evolution pattern field structure under excitation. Primary patterns their interactions were identified through Proper Orthogonal Decomposition (POD) method. Comparing baseline with plasma-excited...
Triple-negative breast cancer (TNBC) is an aggressive subtype of with unmet clinical need, but its epigenetic regulation remains largely undefined. By performing multiomic profiling, we recently revealed distinct super-enhancer (SE) patterns in different subtypes and identified a number TNBC-specific SEs that drive oncogene expression. One these SEs, TCOF1 SE, was discovered to play important oncogenic role TNBC. However, the molecular mechanisms by which SE promotes expression gene remain...
A variety of pipelines are distributed under urban roads. The upgrading is bound to occupy certain road resources, compress the driving space motor vehicles for a long time, aggravate traffic congestion in construction section, and then affect operation whole region. reasonable layout signs inducement guide flow area where section located conducive promoting balanced distribution regional network, so as achieve reduction automobile exhaust emissions sustainable development traffic. In this...
The cell migration and invasion behaviors play pivotal roles in tissue regeneration. For the skin repair process, a directed inflammatory response that regulates fibroblasts is critical for efficient wound healing. In this study, authors present design fabrication of microfluidic-based three-dimensional (3D) microphysiological system how it impacts controlling fibroblast under induction differently polarized macrophages. microfluidic device had two chambers on opposite sides 1 mm...