A5101848434- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Plant Stress Responses and Tolerance
- Biosensors and Analytical Detection
- Photosynthetic Processes and Mechanisms
- Extracellular vesicles in disease
- Acoustic Wave Resonator Technologies
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Cardiac Valve Diseases and Treatments
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- CAR-T cell therapy research
- Cellular transport and secretion
- Organ Donation and Transplantation
- Protein Hydrolysis and Bioactive Peptides
- Environmental Toxicology and Ecotoxicology
- Metabolism and Genetic Disorders
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Nanoparticle-Based Drug Delivery
ShenZhen People’s Hospital
2018-2025
Henan University of Science and Technology
2023
Fujian Agriculture and Forestry University
2023
Shanghai University of Traditional Chinese Medicine
2022
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022
Sichuan University
2019-2020
The People's Hospital of LinXia
2018
Chongqing Medical University
2016
West China Medical Center of Sichuan University
2014
Aflatoxin B1 (AFB1) is a potent natural toxin and carcinogen. Accurate sensitive determination of AFB1 in food great interest. In this work, ratiometric electrochemical aptasensor for the detection peanut its products was constructed. This fabricated by immobilizing Fc-labeled complementary DNA on Thi-rGO/CS/aptamer modified electrode surface through biorecognition between aptamer DNAs. presence AFB1, preferred to form an aptamer-AFB1 complex, resulting separation DNA. With addition more...
Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value epithelial ovarian cancer remains insufficiently investigated. A total 34 patients diagnosis (EOC), 15 benign (TB), 30 healthy volunteers (NOR) were enrolled this study. Fecal samples collected, followed by sequencing V3–V4 region 16S rRNA gene. The clinical data pathological characteristics comprehensively recorded for further...
Abstract Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is cause human tyrosinemia. However, the regulation HPD remains largely unknown. Here, we demonstrate that molecular chaperone TTC36, which highly expressed in liver, associated with and reduces binding protein kinase STK33 to HPD, thereby inhibiting STK33-mediated T382 phosphorylation. The reduction phosphorylation results impaired recruitment FHA domain-containing PELI1...
The strain parameters of Real-Time Three-Dimensional Spot Tracking Echocardiography (RT3D-STE) are GLS, GAS, GRS, and GCS, while each index can significantly diagnose Acute Myocardial Infarction (AMI) patients, but none them distinguish between NSTEMI STEMI. MicroRNAs (miRNAs) play essential roles in (AMI), little is known about the value exosome miRNA combined with ST-segment Elevation (STEMI) Non-ST-segment (NSTEMI).To estimate exosomal miRNAs related to RT3D-STE as biomarkers for early...
The transcription activator-like effector nucleases (TALENs) strategy has been widely used to delete and mutate genes in vitro. This begun be for vivo systemic gene manipulation, but not an organ-specific manner. In this study, we developed a modified, highly efficient TALEN using dual-fluorescence reporter. We modified and, within 5 weeks, successfully generated kidney proximal tubule-specific Ttc36 homozygous knockout mice. Unilateral nephrectomy was performed on the 6-week-old founders...
Ferredoxins (Fds) in plastids are the most upstream stromal electron receptors shuttling electrons to downstream metabolic systems and function various physiological processes of dicots, but their roles monocots’ response stresses still unclear. In this study, functions OsFd4, major non-photosynthetic type Fd rice, were characterized under oxidative stress Xanthomonas oryzae pv. (Xoo) infection. OsFd4-knockout mutants displayed no defects key agronomic traits blast resistance, more sensitive...
Introduction. Hepatocellular carcinoma (HCC) is one of the most common malignant tumours in world. Due to characteristics low early diagnosis rate, high malignancy and rapid progression, majority diagnosed patients are middle or late stage. Accumulating evidence reveals that intestinal flora imbalance will aggravate HCC by disturbing immune regulation, especially interleukin expression. Therefore, flora-based methods have potential be new diagnostic therapeutic for HCC.Hypothesis....
Alternative oxidase (AOX) has been reported to be involved in mitochondrial function and redox homeostasis, thus playing an essential role plant growth as well stress responses. However, its biological functions nonseed plants have not characterized. Here, we report that AOX participates salt tolerance regulation moss Physcomitrella patens (P. patens). is highly conserved localizes mitochondria P. patens. We observed PpAOX rescued the impaired cyanide (CN)-resistant alternative (Alt)...
Bispecific T-cell engagers (BiTEs) are single chain variable fragments, which could connect the surface antigen on cancer cells and CD<sub>3</sub> ligands T cells, then engage for immunotherapy.
BACKGROUND MicroRNAs (miRNAs) play essential roles in acute myocardial infarction (AMI), but little is known regarding the value of exosome miRNA combined with real-time three-dimensional spot tracking echocardiography (RT3D-STE) between ST-segment elevation (STEMI) and non-ST-segment (NSTEMI). AIM To analyze correlation exosomal strain parameters RT3D-STE. METHODS The present study collected plasma samples from thirty-four patients AMI, employed high-throughput sequence technology Real-time...
Abstract Notoginsenoside R1 (NGR1) is isolated from the panax notoginseng which a kind of Traditional Chinese Medicine and edible plant with good healthful effect that using range very wide for medical treatment health care. It had been demonstrated to inhibit various tumors proliferation, but whether it inhibited cervical cancer cells proliferation its mechanism was not unclear. In this study, we showed NGR1 could proliferate time dose dependent manner, induce apoptosis arrest in G1/S-phase...
Abstract BACKGROUND Real-time three-dimensional spot tracking echocardiography (RT3D-STE) can be used to assess the prognosis of myocardial infarction (MI). Analyzing correlation between miRNAs and RT3D-STE, especially Global Longitude Strain (GLS) Circumferential (GCS), provide new ideas for discovering evaluating role in assessing function MI. METHODS The present study collected forty-nine (49) plasma samples (15 normal 34 MI samples; 22 before 12 after intervention therapy) employed...
Background: Real-time three-dimensional spot tracking echocardiography (RT3D-STE) can be used to assess the prognosis of myocardial infarction (MI). Analyzing correlation between miRNAs and RT3D-STE, especially Global Longitude Strain (GLS) Circumferential (GCS), provide new ideas for discovering evaluating role in assessing function MI. Methods: The present study collected forty-nine (49) plasma samples (15 normal 34 MI samples; 22 before 12 after intervention therapy) employed...
Abstract Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors in world. There are a variety treatment options for HCC, such as hepatectomy, radio frequency ablation, radiotherapy and chemotherapy, liver transplantation, etc. However, due to characteristics low early diagnosis rate, high malignancy rapid progression majority diagnosed patients middle or late stage.Therefore, new research ideas needed prevention, prognosis HCC. Accumulating evidence reveals that disease...