A5100639524- Circular RNAs in diseases
- MicroRNA in disease regulation
- Meat and Animal Product Quality
- Protein Hydrolysis and Bioactive Peptides
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Genomics and Rare Diseases
- Food Industry and Aquatic Biology
- Gastroesophageal reflux and treatments
- Genomics, phytochemicals, and oxidative stress
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Biofuel production and bioconversion
- Cancer therapeutics and mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Enzyme Catalysis and Immobilization
- Glass properties and applications
- Essential Oils and Antimicrobial Activity
- Tryptophan and brain disorders
- Insect and Pesticide Research
- Histone Deacetylase Inhibitors Research
- Luminescence Properties of Advanced Materials
- Autophagy in Disease and Therapy
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2022-2024
Peking University
2024
Beijing Institute of Education
2022-2024
Chengdu University
2023
Guiyang Medical University
2022
Affiliated Hospital of Guizhou Medical University
2022
Hangzhou Medical College
2019-2021
Zhejiang Provincial People's Hospital
2019-2021
AstraZeneca (United States)
2021
Second Affiliated Hospital of Zhejiang University
2020
Abstract Dysregulation of circular RNA (circRNA) expression is involved in the progression cancer. Here, we aimed to study potential function hsa_circ_0006401 colorectal cancer (CRC). CircRNA levels CRC and adjacent nontumor tissues were analyzed by real-time quantitative PCR (qRT-PCR) circRNA situ hybridization (RNA-ISH). Then, cell proliferation was assessed counting. Wound-healing transwell assays utilized detect effect on migration. A circRNA-ORF construct created, a specific antibody...
The aim of this study is to isolate and identify a novel corn peptide (CP) from zein with antioxidant antihypertensive activities based on bioactive-guided isolation procedures. Zein was hydrolyzed by using double enzymes immobilized calcium alginate-chitosan beads then fractionated purified. the CP fractions were screened in vitro vivo assays. animal studies spontaneously hypertensive rats (SHRs) confirmed effects CP, its angiotensin I-converting enzyme (ACE) inhibitory activity retained...
Abstract Nuclear factor erythroid 2‐related 2 (Nrf2) significantly contributes to drug resistance of cancer cells, and Nrf2 inhibitors have been vigorously pursued. Repurposing existing drugs, especially anticancer is a straightforward promising strategy find clinically available effective combinations. Topoisomerase SN‐38 (an active metabolite irinotecan), topotecan, mitoxantrone, epirubicin were found suppress transcriptional activity in cells. SN‐38, the most potent one among them,...
Background: Sinapine thiocyanate (ST), an alkaloid isolated from the seeds of cruciferous species, has exhibited anti-inflammatory, anti-malignancy, and anti-angiogenic effects in previous studies. However, molecular mechanisms action ST pancreatic cancer (PC) are still limited. Materials methods: PC cells were treated with different concentrations (0, 20, 40, 80 μM) ST. The proliferative ability vitro was determined using cell count kit-8 (CCK-8), 5-ethynyl-2' deoxyuridine, colony...
A Tm3+, La3+: CaF2 single crystal was grown, and its spectral properties laser performance were investigated. Under diode end-pumping, a continuous-wave has been demonstrated. The slope efficiency of up to 67.8% first achieved in the co-doping crystal, which is close twice theoretical quantum efficiency. maximum output power 4.269 W broad tunable range 192 nm also obtained, indicating this system promising candidate for highly efficient ∼2 μm lasers.
Aims: To profile and characterize the circular RNA (circRNA) expression pattern in poorly differentiated gastric adenocarcinoma (PDGA). Methods & materials: CircRNA profiles PDGA adjacent nontumor tissues were analyzed by microarray. Five randomly selected expressed circRNAs (DECs) validated real-time quantitative PCR. m6A qualification of top 20 DECs was conducted m6A-immunoprecipitation Results: A total 65 found compared with control. Hsa_circRNA_0077837 had largest area under curve. Most...
Gastric cancer (GC) is a serious digestive tract disease that threatens human life worldwide, and the prognosis of gastric accompanied by distant lymph node or metastasis organs worse. The purpose this study was to investigate role circular RNA COL6A3_030 (circBase ID: hsa_circ_0006401; circRNADb hsa_circ_28198; circBank hsa_circCOL6A3_030) in GC metastasis. qRT-PCR analysis using back-splicing primers Sanger sequencing PCR products were performed identify circCOL6A3_030 tissues cell lines;...
In the present study, Ultrasonic-Microwave (US-MW) technique was applied for assisting enzymatic hydrolysis of freshwater mussel meat. The operating parameters were investigated and properties qualities hydrolysates also analyzed. considerable optimum conditions meat ratio liquid to material 10.36:1, power 360.52 W, processing time 6.91 min, enzymolysis 4 h. Under these conditions, a degree (DH) 48.40% obtained. produced under characterized in terms electrophoretic profile, amino acid...
In the present study, Ultrasonic-Microwave (US-MW) technique was applied for assisting enzymatic hydrolysis of freshwater mussel meat. The operating parameters were investigated and properties qualities hydrolysates also analyzed. considerable optimum conditions meat ratio liquid to material 10.36:1, power 360.52 W, processing time 6.91 min, enzymolysis 4 h. Under these conditions, a degree (DH) 48.40% obtained. produced under characterized in terms electrophoretic profile, amino acid...
Abstract Background: Dysregulation of circular RNA (circRNA) expression is involved in the progression cancer. Here, we aimed to study potential function hsa_circ_0006401 colorectal cancer (CRC). Methods: CircRNA levels CRC and adjacent nontumor tissues were analyzed by real-time quantitative PCR (qRT-PCR) circRNA situ hybridization (RNA-ISH). Two siRNAs designed according splice junction hsa_circ_0006401, both effectively downregulated level. Then, cell proliferation was assessed counting....
Abstract Background Gastric cancer (GC) is a serious digestive tract disease that threatens human life worldwide, and the prognosis of gastric accompanied by distant lymph node or metastasis organs worse. The purpose this study was to investigate role circular RNA COL6A3_030 (circBase ID: hsa_circ_0006401; circRNADb hsa_circ_28198; circBank hsa_circCOL6A3_030) in GC metastasis. Methods qRT-PCR analysis using back-splicing primers Sanger sequencing PCR products were performed identify...