A5031066631- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Rheumatoid Arthritis Research and Therapies
- TGF-β signaling in diseases
- Musculoskeletal synovial abnormalities and treatments
- Exercise and Physiological Responses
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Veterinary Equine Medical Research
- Protease and Inhibitor Mechanisms
University of Liverpool
2018-2023
Centre for Life
2023
Maastricht University Medical Centre
2020
CellSight Technologies (United States)
2017
Kazakh National Medical University
2015
ObjectiveFor many proteins from osteoarthritic synovial fluid, their intra-articular tissue of origin remains unknown. In this study we performed comparative proteomics to identify osteoarthritis-specific and joint tissue-dependent secreted that may serve as candidates for osteoarthritis biomarker development on a tissue-specific basis.DesignProtein secretomes cartilage, synovium, Hoffa's fat pad meniscus knee patients were determined using liquid chromatography tandem mass spectrometry,...
Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene expression regulators that act post-transcriptionally to control tissue homeostasis. Microarray analysis was undertaken in osteoarthritic intact, lesioned and young intact cartilage. Principal component showed cartilage samples were clustered together; had a wider distribution; separated into two subgroups, osteoarthritic-Intact-1 osteoarthritic-Intact-2. We identified 318 differentially expressed microRNAs...
// Ping Niu 1,* , Aibek Smagul 2,* Lu Wang 3 Aiman Sadvakas 2 Ying Sha Laura M. Pérez 4 Aliya Nussupbekova Aday Amirbekov Akan A. Akanov Beatriz G. Gálvez I. King Jordan 3,5 and Victoria V. Lunyak 6 1 Department of Pediatrics, Renmin Hospital Wuhan University, Wuhan, China S.D. Asfendiyarov Kazakh National Medical Almaty, Kazakhstan School Biology, Georgia Institute Technology, Atlanta, GA Cardiac Development Repair Department, Center for Cardiovascular Research (CNIC), Madrid, Spain 5...
Abstract Although pathways controlling ribosome activity have been described to regulate chondrocyte homeostasis in osteoarthritis, biogenesis osteoarthritis is unexplored. We hypothesized that U3 snoRNA, a non-coding RNA involved ribosomal maturation, critical for protein translation capacity osteoarthritis. snoRNA was one of number snoRNAs with decreased expression osteoarthritic cartilage and chondrocytes. OA synovial fluid impacted by affecting gene promoter activity, while BMP7 able...
Growing evidence suggests that many diseases of aging, including associated with robust changes and adipose deports, may be caused by resident adult stem cell exhaustion due to the process called cellular senescence. Understanding how microRNA pathways can regulate senescence is crucial for development novel diagnostic therapeutic strategies combat these pathologies. Herein, using integrated transcriptomic semi-quantitative proteomic analysis, we provide a system level view regulation human...
Articular conditions are common in horses and can result loss of function, chronic pain and/or inability to work. Common include osteoarthritis, osteochondrosis synovial sepsis, which be life-threatening, but despite the high clinical prevalence these conditions, rapid specific diagnosis, monitoring prognostication remains a challenge for practicing veterinarians. Synovial fluid from range arthropathies was enriched low abundance proteins using combinatorial peptide ligand ProteoMiner™ beads...
Polyadenylation (polyA) defines the 3′ boundary of a transcript’s genetic information. Its position can vary and alternative polyadenylation (APA) transcripts exist for gene. This causes variance in regulatory domains affect coding sequence if intronic events occur. The distribution polyA sites on articular chondrocyte has not been studied so we aimed to define their transcriptome-wide location age-matched healthy osteoarthritic knee cartilage. Total RNA was isolated from frozen tissue...
Objective: to study the role of PRG4 in modulating myofibroblast differentiation OA fibroblast-like synoviocytes (OA FLS) and whether this effect is mediated by interaction with CD44.
ABSTRACT An important transcript structural element is its 3’ polyadenylated (polyA) tail, which defines the boundary of transcript’s genetic information and necessary for stability. The position polyA tail can vary, with multiple alternatively (APA) transcripts existing a single gene. This lead to different length vary in their regulatory domains even by inclusion or exclusion protein-coding introns. distribution location on articular chondrocyte has not been examined before this study...