A5103269876- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- MicroRNA in disease regulation
- Medicinal plant effects and applications
- Acute Myocardial Infarction Research
- Fibroblast Growth Factor Research
- Autophagy in Disease and Therapy
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- RNA modifications and cancer
- Innovations in Medical Education
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Ovarian function and disorders
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- SARS-CoV-2 and COVID-19 Research
- Galectins and Cancer Biology
- Genetic Associations and Epidemiology
- Circular RNAs in diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nerve injury and regeneration
- Natural Antidiabetic Agents Studies
Zhongshan People's Hospital
2025
Wuhan University
2013-2024
Zhongnan Hospital of Wuhan University
2013-2024
Shanghai Eighth People Hospital
2021-2023
GTx (United States)
2020
Army Medical University
2015-2016
Xinqiao Hospital
2016
Sun Yat-sen University
2010-2011
Huazhong University of Science and Technology
2011
Third Affiliated Hospital of Sun Yat-sen University
2010-2011
Soluble dietary fiber (DF) reduces the risk of developing diabetes and may have therapeutic effects in patients with type 2 mellitus (DM2). The present study aimed to investigate effect soluble DF on metabolic control DM2. A total 117 DM2 between ages 40 70 were assessed. Patients randomly assigned one two groups, administered extra (10 or 20 g/day), a group (0 g/day) for month. Blood glucose, serum insulin connecting peptide (C-peptide) levels, resistance index, as determined using...
Abstract Diabetic angiopathy is a major diabetes‐specific complication that often begins with endothelial dysfunction induced by hyperglycemia; however, the pathological mechanisms of this progression remain unclear. Ampelopsin natural flavonol has strong antioxidant activity, but little information available regarding its antidiabetic effect. This study focused on effect ampelopsin hyperglycemia‐induced oxidative damage and underlying mechanism in human umbilical vein cells (HUVECs). We...
Genomic variants identified by genome-wide association studies (GWAS) explain <20% of heritability coronary artery disease (CAD), thus many risk remain missing for CAD. Identification new may unravel biological pathways and genetic mechanisms To identify associated with CAD, we developed a candidate pathway-based GWAS integrating expression quantitative loci analysis mining data in pathway.Mining was performed to analyze 32 complement system genes positive Functional showing were then...
Ampelopsin (APL), a major bioactive constituent of Ampelopsis grossedentata, exerts number biological effects. Here, we explored the anti-diabetic activity APL and elucidate underlying mechanism this action. In palmitate-induced insulin resistance L6 myotubes, treatment markedly up- regulated phosphorylated receptor substrate-1 protein kinase B, along with corresponding increase glucose uptake capacity. also increased expressions fibroblast growth factor (FGF21) adenosine 5'-monophosphate...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) and gallstone (GSD) often coexist in the general population owing to shared risk factors. This study explored relationship between NAFLD GSD patients with type 2 diabetes. Methods We conducted a retrospective cross-sectional analysis of 4325 were confirmed using ultrasonography. was defined as either asymptomatic gallstones or previous cholecystectomy, each analyzed separately. Result There no significant difference prevalence...
Introduction This article aimed to compare the prevalence of dyslipidemia and determine risk factors associated with lipid levels in a cohort HIV-infected patients receiving two different antiretroviral therapy (ART) regimens, nucleoside reverse transcriptase inhibitor/non-nucleoside inhibitor (NRTI/NNRTI) inhibitor/integrase strand transfer (NRTI/INSTI). Methods longitudinal study analyzed 633 complete blood profile records for at least 1 year ART clinic Zhongnan Hospital Wuhan University,...
PPARγ is a member of the nuclear hormone receptor superfamily. It has been considered as mediator regulating metabolism, anti-inflammation, and pro-proliferation in Vascular Smooth Muscle Cells (VSMCs). Thiazolidinediones (TZDs), synthetic ligands PPARγ, have anti-proliferative pro-apoptotic effects on VSMCs, which prevent formation progression atherosclerosis restenosis following percutaneous coronary intervention (PCI). However, underlying mechanism remains elusive. This present study...
To investigate the association between non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density cholesterol ratio degree of coronary artery stenosis proven by angiography.A total 1867 patients were enrolled into this study analyzed retrospectively. Three hundred eighty-five non-coronary disease hospitalized selected as control group, 1482 diagnosed classified three subgroups according to tertiles their SYNTAX score. We compared level among subgroups. The Spearman...
Abstract The enzymatic synthesis of short boranophosphate RNA was studied by comparing the yield and pattern abortive products in vitro transcription at steady-state conditions with that normal RNA. Boranophosphate can be readily synthesized T7 polymerase. Keywords: BoranophosphateTranscriptionRNA
Abstract Background: The available evidence regarding the benefits of percutaneous coronary intervention (PCI) on patients receiving dialysis with artery disease (CAD) is limited and inconsistent. This study aimed to evaluate association between PCI clinical outcomes as compared medical therapy alone in undergoing CAD China. Methods: multicenter, retrospective was conducted 30 tertiary centers across 12 provinces China from January 2015 June 2021 include CAD. primary outcome major adverse...
Objective: To analyze the clinical characteristics of Hepatic venous-occlusive disease induced by Gynura segetum. Methods: The process diagnosis and treatment patient with who are admitted to Zhongnan hospital. Results: has following features: he is an old man a history taking segetum abdominal distension, pain, ascites. We can medical auxiliary examination. Conclusions: important predisposing factor for veno-occlusive disease. manifestations mainly liver dysfunction abnormal coagulation...
Noviciate is an important period in which medical students study both theorotical and clinical knowledge of gynecology.To improve teaching quality gynecological noviciate,manifold methods are applied,such as case-based teaching,problem based teaching,bedside teaching,simulation teaching.These enhance the comprehensive students. Key words: Gynecology; ; Teaching method
This paper is to explore how .to guide students' active learning and strengthen training , clinical thinking during clerkship in gynecological obstetric department. Kinds of teaching methods were took the Third Affiliated Hospital SUN Yat-sen University recent years,including by case, problem-based learning, encouraging practice question strengthening thinking, which welcomed made students not only mastered basic theory knowledge systematically, but also model scientifically, good effects...