A5068556809- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiac pacing and defibrillation studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Neuroscience and Neural Engineering
- Health Systems, Economic Evaluations, Quality of Life
- Carcinogens and Genotoxicity Assessment
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Effects of Exercise
- Peptidase Inhibition and Analysis
- Cardiovascular Function and Risk Factors
- Pharmaceutical Economics and Policy
- Cardiac Valve Diseases and Treatments
- Regulation of Appetite and Obesity
- Connexins and lens biology
- Curcumin's Biomedical Applications
- Tea Polyphenols and Effects
- School Health and Nursing Education
Aerospace Center Hospital
2017-2025
Peking University
2003-2025
Guangzhou University of Chinese Medicine
2011-2021
King University
2020
Guangdong Provincial Hospital of Traditional Chinese Medicine
2011-2016
Guangdong Academy of Medical Sciences
2015-2016
University of California, San Francisco
2006-2015
Sun Yat-sen Memorial Hospital
2014
Sun Yat-sen University
2014
Anhui Medical University
2011
Background— Atrial fibrosis is an important substrate in atrial fibrillation (AF), particularly the setting of structural heart disease. In a canine model, congestive failure (CHF) produces significant and for sustained AF. This remodeling potential therapeutic target. The objective present study to evaluate effects antifibrotic drug pirfenidone (PFD) on arrhythmogenic CHF model. Methods Results— We studied 15 canines, divided equally into 3 groups: control, canines not treated with PFD,...
Electrical cardiac forces have been previously hypothesized to play a significant role in morphogenesis and remodeling. In response electrical forces, cultured cardiomyocytes rearrange their cytoskeletal structure modify gene expression profile. To translate such vitro data the intact heart, we used collection of zebrafish mutants transgenics investigate whether conduction could influence vivo independent contractile forces. We show that mutant dco s226 develops heart failure interrupted...
AimsAnimal studies show that transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and fibrillation (AF). This study investigated the role TGF-β1 in human AF mechanism atrial-selective fibrosis.
Cell replacement strategies are promising interventions aiming to improve myocardial performance. Yet, the electrophysiological impact of these approaches has not been elucidated. We assessed consequences grafting two candidate cell types, that is, skeletal myoblasts and human embryonic stem cell-derived cardiomyocytes (hESC-CMs). The fluorescently labeled (DiO) cells were grafted into rat's left ventricular myocardium. Two weeks later, optical mapping was performed using...
Abstract Background Cancer and coronary artery disease (CAD) is reported to often co-exist in same individuals, however, whether cancer directly associated with anatomical severity of CAD rarely studied. The present study aimed observe the relationship between newly diagnosed CAD, moreover, investigate effect inflammation on CAD. Methods 374 patients who underwent angiography (CAG) were enrolled. Through 1:3 propensity score matching (PSM) based age gender among 51,106 non-cancer CAG, 1122...
A large cohort of 74,828 benzene-exposed and 35,805 nonexposed workers employed between 1972 1987 in 12 cities China was followed to determine mortality from all causes. Benzene-exposed study subjects were a variety occupations including coating applications, rubber, chemical, shoe production. Mortality slightly increased among with greater cumulative exposure benzene (ptrend < 0.05), but this excess largely due cancer deaths 0.01). Deaths lymphatic hematopoietic malignancies = 0.01) lung...
In this study the relation between lysophosphatidic acid (LPA) and myocardial infarction was investigated, typical simplified methods for measuring serum LPA concentration by dot immunogold filtration assay (DIFA) based on a polyclonal antibody to were developed, concentrations measured in 31 patients with acute (AMI) 12 controls (blood donors) DIFA. Serum levels raised more than twofold 8 h after onset of AMI. Maximal elevation (10.43 mg/L) found at 48–72 following remained higher control...
Shensong Yangxin (SSYX) capsule is a traditional Chinese medicine that has been used widely to treat cardiac arrhythmia. This study aimed assess whether SSYX prevents atrial fibrillation (AF) after chronic myocardial infarction (MI)-induced heart failure and determine the underlying mechanisms.The included 45 male Sprague Dawley rats. The rats underwent MI induction or sham surgery. One week surgery, we performed serial echocardiography administered some experienced MI. After 4 weeks of...
Background: Ventricular tachycardia (VT) is a common cause of mortality in post-myocardial infarction (MI) patients, even the current era coronary revascularization treatment. We report reproducible VT model rats with chronic MI induced by ischemia-reperfusion and describe its electrophysiological characteristics using high-resolution optical mapping. Methods: An was generated left anterior descending ligation (25 minutes) followed reperfusion 20 rats. Electrophysiology study mapping were...
Tannic acid presents in varying concentrations plant foods, and relatively high green teas red wines. Human ether-à-go-go-related gene (hERG) channels expressed multiple tissues (e.g. heart, neurons, smooth muscle cancer cells), play important roles modulating cardiac action potential repolarization tumor cell biology. The present study investigated the effects of tannic acid, wines on hERG currents. currents stably transfected HEK293 cells were studied with a perforated patch clamp...
Abstract Benzene is recognized internationally as a leukemogen, but the available data to clarify dose‐response relationships and examine risks of malignancies other than leukemia are sparse. A collaborative study was therefore carried out expand on previous retrospective cohort mortality Chinese benzene‐exposed workers. Methods resources used in 16‐year follow‐up 74,828 35,805 unex‐posed workers employed for any length time during 1972–1987 712 factories 12 cities China described. Details...
Abstract Despite the controversy in mechanism, rodent and clinical studies have demonstrated beneficial effects of stem/progenitor cell therapy after myocardial infarction ( MI ). In a rat ischaemic reperfusion model, we investigated immunomodification CD 34 + cells on heart function conduction. Bispecific antibody (BiAb), consisting an anti‐myosin light chain anti‐ 45 antibody, injected intravenously was used to direct human injured myocardium. Results were compared echocardiography guided...
Recent research indicates that nerve growth factor (NGF) promotes cardiac repair following myocardial infarction by promoting angiogenesis and cardiomyocyte survival. The purpose of this study was to investigate the effects NGF on fibroblasts (CFs) proliferation, cell cycle, migration, myofibroblast transformation in vitro.CFs were obtained from ventricles neonatal Sprague-Dawley rats incubated with various concentrations (0, 0.01, 0.1, 1, 10, 100 ng/ml; 0 ng/ml designated as control group)....
Numerous clinical studies reported the effectiveness of herbal formula WuShen (WS) in treating cardiovascular diseases, yet relevant basic research was rarely conducted.Twelve main bioactive compounds WS decoction were identified using ultra-performance liquid chromatography-LTQ-Orbitrap mass spectrometer. A total 137 active with 613 targets predicted by network pharmacology; their bioinformatic annotation and human microarray data suggested that wounding healing, inflammatory response, gap...