A5003564506- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Pain Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Calpain Protease Function and Regulation
- Cerebrovascular and Carotid Artery Diseases
- Inflammasome and immune disorders
- Saffron Plant Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Healthcare and Venom Research
- Neurological Disorders and Treatments
- Protease and Inhibitor Mechanisms
- 3D Printing in Biomedical Research
- Autophagy in Disease and Therapy
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Medical Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Advanced Glycation End Products research
First Affiliated Hospital of Jinan University
2016-2025
Peking University
2025
Aerospace Center Hospital
2025
Zhengzhou City Hospital
2024
Jinan University
2013-2021
Tianjin First Center Hospital
2021
Tianjin Medical University
2021
Beijing Ditan Hospital
2019
Capital University
2011-2019
Capital Medical University
2011-2019
Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Prediction penumbra existence after AIS crucial for making decision on reperfusion therapy. Yet fast, inexpensive, simple, noninvasive predictive biomarker the poststroke with clinical translational potential still lacking. We aim to investigate whether CircOGDH (circular RNA derived from oxoglutarate dehydrogenase) in patients its role neuronal damage. Methods: was screened middle cerebral...
Abstract Nanomedicine based brain targeting strategies have emerged as a promising avenue for ischemic stroke (IS) treatment. However, conventional approaches face significant challenges in manipulating biodistribution and achieving efficient to attain adequate therapeutic effects. Here, this limitation is overcame by developing magnetic field driven, mitochondria‐targeted ceria nanosystem (MMTCe) nanosystem. By anchoring nanoparticles the cell membrane, targeted delivery of achieved through...
Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone that increases glucose-dependent insulin secretion to reduce the glucose level. Liraglutide, a long-acting GLP-1 analogue, has been found have neuroprotective action in various experimental models. However, protective mechanisms of liraglutide ischaemic stroke remain unclear. Here, we demonstrated significantly decreased infarct volume, improved neurologic deficits and lowered stress-related hyperglycaemia without causing...
Blood-brain barrier (BBB) damage can be a result of central nervous system (CNS) diseases and may cause CNS deterioration. However, there are still many unknowns regarding effective targeted therapies for maintaining BBB integrity during ischemia/reperfusion (I/R) injury. In this study, we demonstrate that the circular RNA FoxO3 (circ-FoxO3) promotes autophagy via mTORC1 inhibition to attenuate collapse under I/R. Upregulation circ-FoxO3 autophagic flux were detected in brain microvessel...
Exosomes contribute to cell–cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions. However, the underlying mechanisms microglia-derived exosome biosynthesis are largely unknown. Herein, we reported PDE1-B expression was progressively elevated peri-infarct region after focal middle cerebral artery occlusion. By an oxygen-glucose-deprivation (OGD) model cells, found inhibition by vinpocetine...
Ten new crocins, neocrocins B-J (1-9) and 13-cis-crocetin-8'-O-β-d-gentiobioside (14), along with 10 known were isolated from the fruits of Gardenia jasminoides Ellis (Gardeniae Fructus). The structures these compounds elucidated by analyzing HRESIMS, UV/vis, 1D 2D NMR spectra, their neuroprotective effects against hydrogen peroxide- l-glutamic acid-induced SH-SY5Y cell injury evaluated. UPLC-Q/TOF-MS chromatogram a crocin-rich fraction derived gardenia fruit extracts was established using...
Many hospitals lack facilities for accurate diagnosis of acute ischemic stroke (AIS). Circular RNA (circRNA) is highly expressed in the brain and closely associated with stroke. In this study, we examined whether blood-borne circRNAs could be promising candidates as adjunctive diagnostic biomarkers their pathophysiological roles after We profiled blood circRNA expression mice subjected to experimental focal cerebral ischemia validated selected AIS patients. demonstrated that 128, 198, 789...
Microglial activation is one of the causative factors for neuroinflammation, which associated with pathophysiology neurodegenerative diseases. Our previous study showed that flavonoid luteolin inhibited several pro-inflammatory enzymes and cytokines are induced by activated microglia; however, its effect on signaling pathways currently unknown. The present examined effects stimulated lipopolysaccharide (LPS), including Toll-like receptor-4 (TLR-4), nuclear transcription factor-κB (NF-κB),...
We aimed to develop and validate a new nomogram for predicting the risk of intracranial hemorrhage (ICH) in patients with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT).A retrospective study enrolled 553 AIS treated IVT. The were randomly divided into two cohorts: training set (70%, n = 387) testing (30%, 166). factors predictive filtered using multivariable logistic regression analysis. performance was assessed based on area under receiver operating characteristic curve...
Background: The latest Global Burden of Disease study indicates that stroke remains the second major cause death. Promising protective effects have been shown in most studies ischemic (IS) protection preclinical animal models, but failed to enter clinical trials. objective this is investigate brain cytoprotective natural compound MBS-1 IS, using a novel, rigorous, and feasible paradigm inspired by Stroke Preclinical Assessment Network (SPAN). Methods: This performs SPAN methodology two...
Ischemic stroke is usually followed by inflammatory responses mediated microglia. However, the effect of statins on directly preventing posthypoxia microglia factors to prevent injury surrounding healthy neurons unclear. Atorvastatin and rosuvastatin, which have different physical properties regarding their lipid water solubility, are most common HMG-CoA reductase inhibitors (statins) might block neurons. Neuronal damage microglial activation peri-infarct areas were investigated Western...
Receptor for advanced glycation end products (RAGEs), a multiligand receptor belonging to the cell-surface immunoglobulin superfamily, has been reported play crucial role in neuroinflammation and neurodegenerative diseases. Here, we tested our hypothesis that RAGE-specific antagonist FPS-ZM1 is neuroprotective against ischemic brain injury. Distal middle cerebral artery occlusion (MCAO) or sham operation was performed on anesthetized Sprague-Dawley male rats (n = 60), which were then treated...
With the increasing prevalence of diabetes in recent years, diabetic nephropathy (DN) has also become a dangerous disease that greatly endangers human health. The study was designed to determine mechanism and effect Electro-acupuncture (EA) alleviating DN-induced inflammation.Mice were intraperitoneally injected with STZ (streptozotocin, 50 mg/kg, S0130, Sigma, St. Louis, MO, USA) for five consecutive days. After 12 weeks induction, blood glucose levels measured (>300 mg/dL).The serum IL-1β...
Few studies have investigated the properties and protein composition of small extracellular vesicles (sEVs) derived from neurons under hypoxic conditions. Presently, extent involvement these plentiful sEVs in onset progression ischemic stroke remains an unresolved question. Our study systematically identified characteristics conditions (HypEVs) by physical characterization, sEV absorption, proteomics transcriptomics analysis. The effects HypEVs on neurites, cell survival, neuron structure...
Exploring and expanding the indications of common clinical drugs, such as statins, is important to improve prognosis patients with permanent cerebral infarction. It has been suggested that reversing defects in cellular autophagy ER stress statin therapy may be a potential treatment option for reducing ischemic damage. Male Sprague-Dawley rats underwent middle artery occlusion (PMCAO) by electrocoagulation surgery. Atorvastatin (ATV, 10 mg/kg/day) or vehicle was administered...
Hemorrhagic transformation (HT) is a serious complication that stimulates inflammation during reperfusion therapy after acute ischemic stroke. Rosuvastatin, 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, might improve the outcome of HT by inhibiting neuroinflammation. This study aimed to explore protective effects rosuvastatin against recombinant tissue plasminogen activator (rt-PA) treatment in mice with experimental stroke via attenuation inflammation. total one...