A5057206734- HIV Research and Treatment
- Meningioma and schwannoma management
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Pituitary Gland Disorders and Treatments
- Immunotherapy and Immune Responses
- Adrenal and Paraganglionic Tumors
- Viral-associated cancers and disorders
- Advanced Operator Algebra Research
- Neurofibromatosis and Schwannoma Cases
- Cerebrovascular and Carotid Artery Diseases
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Homotopy and Cohomology in Algebraic Topology
- Vascular Malformations Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Geometric and Algebraic Topology
- Bone Tumor Diagnosis and Treatments
- Geometric Analysis and Curvature Flows
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- T-cell and Retrovirus Studies
- Cerebral Venous Sinus Thrombosis
- Advancements in Photolithography Techniques
University of Pittsburgh
2014-2025
Azienda di Rilievo Nazionale ed Alta Specializzazione
2022
University of Parma
2008-2019
Sapienza University of Rome
2010-2019
Fondazione Poliambulanza Istituto Ospedaliero
2019
Institut de Recherche Vaccinale
2014
Graduate School USA
2010
Pittsburg State University
2010
Swedish University of Agricultural Sciences
2009
McMaster University
2008
Abstract Human herpesvirus 8 (HHV-8) causes Kaposi’s sarcoma and pleural effusion lymphoma. In this study, we show that dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209) is a receptor for HHV-8 infection of myeloid DCs macrophages. DC-SIGN was required virus attachment to these cells DC-SIGN-expressing cell lines. binding were blocked by anti-DC-SIGN mAb soluble DC-SIGN, mannan, natural ligand DC-SIGN. Infection macrophages with led production viral proteins, little DNA,...
Induced pluripotent stem cell (iPSC)-based technologies offer an unprecedented opportunity to perform high-throughput screening of novel drugs for neurological and neurodegenerative diseases. Such screenings require a robust scalable method generating large numbers mature, differentiated neuronal cells. Currently available methods based on differentiation embryoid bodies (EBs) or directed adherent culture systems are either expensive not scalable. We developed protocol large-scale generation...
The current literature reports many measurements (arteriovenous oxygen content difference and cerebral metabolic rate of oxygen, etc.) with samples from the internal jugular veins (IJs), obtained either side neck, based on assumption that a reliable sample mixed venous blood can be drawn. We compared saturation in both IJs 32 patients head injuries to establish similarities or discrepancies two veins. Both were cannulated 20-G catheters; five patients, fiberoptic catheter was used obtain...
Infection of T cells by HIV-1 can occur through binding virus to dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) on and transfer CD4+ cells. Here we show that a subset B in the blood tonsils normal donors expressed DC-SIGN, this increased after stimulation vitro with interleukin 4 CD40 ligand, enhanced expression activation co-stimulatory molecules CD23, CD58, CD80, CD86, CD22. The activated captured internalized X4 R5 tropic strains HIV-1, mediated trans infection...
Objective To define the role of wait-and-scan and radiotherapy (RT) in treatment temporal bone paragangliomas to review literature on outcomes RT as a modality. Materials Methods This was retrospective review. The records 381 patients with 382 tumors between 1988 2012 were analyzed. Patients who subjected initial or primary analyzed for tumor response, facial, lower cranial nerve status follow-up (FU). Results Observations None 145 (38%) Class A B all operated on. Of 237 (62%) C D tumors, 47...
We examined the emergence of CXCR4 (i.e., X4) tropism in 67 male human immunodeficiency virus type 1 (HIV-1) seroconverters from Multicenter AIDS Cohort Study (MACS) who were selected to reflect full spectrum rates HIV-1 disease progression. A mean 10 serial samples per donor evaluated by a laboratory-validated, commercially available assay determine phenotypic coreceptor use.Atotal 52% men had dual- or mixed-tropic detected at more time points tested. Use X4 was frequently among developed...
<b><i>Objectives:</i></b> To investigate the long-term results of preoperative stenting internal carotid artery (ICA) in complex head and neck paragangliomas (HNP) as well to report on indications technical details procedure. <b><i>Method:</i></b> A comprehensive retrospective review patients affected by HNP, consecutively operated preoperatively treated with ICA a quaternary referral skull base center, was performed....
Abstract Background HIV-1 is associated with accelerated aging. The senescence-associated secretory phenotype (SASP) includes biological and cytokine profiles that induce cellular senescence inflammaging. In this study, we leveraged the Multicenter AIDS Cohort Study (MACS) to evaluate role of SASP in aging, reservoir, inflammation people (PWH) on long-term suppressive antiretroviral therapy (ART). Methods retrospective study included plasma serum samples from 27 virally- suppressed PWH 10...
Background: HIV-1 infection is associated with accelerated aging. The senescence-associated secretory phenotype (SASP) includes biological and cytokine profiles that induce cellular senescence inflammaging. In this study, we leveraged the Multicenter AIDS Cohort Study (MACS) to evaluate role of SASP in aging, reservoir, inflammation people (PWH) on long-term suppressive antiretroviral therapy (ART). Methods: retrospective included plasma serum samples from 27 virally suppressed PWH 10...
Objective: To induce complete and reproducible repigmentation of large "stable" vitiligo lesions by means autologous cultured epidermal grafts using a rapid, simple, minimally invasive surgical procedure.Design: Achromic epidermis was removed appropriately settled erbium:YAG laser, were applied onto the recipient bed.Melanocyte content evaluated dopa reaction.The percentage calculated semiautomatic image analysis system.Setting: A biosafety level 3-type cell culture facility, ambulatory...
Cytotoxic T lymphocytes (CTL) play an important role in the control and elimination of infection by West Nile virus (WNV), yet class I human leukocyte antigen (HLA)-presented peptide epitopes that enable CTL recognition WNV-infected cells remain uncharacterized. The goals this work were first to discover distinguish HLA then test cell reactivity newly discovered WNV epitopes. To WNV-immune epitopes, was harvested from (NY99 strain)-infected uninfected HeLa cells. Then eluted...
Prognosis varies among persons with West Nile virus (WNV) infection, but the most important factors associated persistent symptoms are not clear. In this cross-sectional study, 265 symptomatic WNV infection during 2006-2008 completed a survey mean of 7.7 months after diagnosis. We determined association demographic and clinical characteristics to common symptoms. Of 214 infected ≥ 6 months, 53% reported one or more symptoms, including fatigue, muscle aches, decreased activity, difficulty...
One of the commonest complications Plasmodium falciparum malaria is development severe malarial anemia (SMA), which is, at least in part, due to malaria-induced suppression erythropoiesis. Factors associated with erythropoiesis and SMA include accumulation pigment (hemozoin, PfHz) bone marrow altered production inflammatory mediators, such as tumor necrosis factor (TNF)-α, nitric oxide (NO). However, studies investigating specific mechanisms responsible for inhibition red blood cell have...
A variety of neurological disorders including neurodegenerative diseases and infection by neurotropic viruses can cause structural functional changes in the central nervous system (CNS), resulting long-term sequelae. An improved understanding pathogenesis these is important for developing efficacious interventions. Human induced pluripotent stem cells (hiPSCs) offer an extraordinary window modeling pathogen-CNS interactions, other cellular three-dimensional (3D) neuronal cultures that...
The present investigation focuses on the analysis of interactions among human lactoferrin (LF), SARS-CoV-2 receptor-binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2) receptor in order to assess possible mutual that could provide a molecular basis reported preventative effect against CoV-2 infection. In particular, kinetic thermodynamic parameters for pairwise three proteins were measured via two independent techniques, biolayer interferometry latex nanoparticle-enhanced...
To identify complex cases of tympanojugular paraganglioma (TJP) and to analyze their management surgical outcome. present strategy guidelines on how deal with the perioperative complicating factors.Retrospective analysis.We retrospectively studied 212 TJP patients analyzed The criteria for are: 1) very large size; 2) intradural extension (IDE); 3) cavernous sinus, foramen magnum, clivus; 4) significant involvement internal carotid artery (ICA); 5) a solitary ICA lesion side; 6) vertebral...
ABSTRACT HIV-1-infected nonprogressors (NP) inhibit disease progression for years without antiretroviral therapy. Defining the mechanisms this resistance to could be important in determining strategies controlling HIV-1 infection. Here we show that two types of professional antigen-presenting cells (APC), i.e., dendritic (DC) and B lymphocytes, from NP lacked ability mediate trans infection CD4 + T cells. In contrast, APC progressors (PR) HIV-1-seronegative donors (SN) were highly effective...
Abstract Background Management of the cervical and petrous internal carotid artery (ICA) is frequently required in Fisch class C tympanojugular paragangliomas (TJPs). The purpose this study was to discuss perioperative intervention ICA patients who underwent surgical resection a TJP. Methods A retrospective 237 surgically treated for TJPs done identify cases that management. Results 176 (74.2%). Forty‐two just an decompression, 88 subperiosteal dissection, 19 subadventitial dissection...
The purpose of this study was to evaluate the GH response exercise and effects endurance training on in early middle-aged men. Seven healthy [M; 42.0+/-2.4 (+/-SD) yr old] five young (Y; 21.2+/-1.1 old) competition cyclists were investigated before after 4 months intensive training. Subjects performed an exhaustive incremental test (50 watts for 3 min) with gas exchange measurement, blood samples lactate, glucose, determinations drawn exercise, at end recovery phase (1, 3, 5, 10, 15, 20, 30...
30 patients aged between 45 and 78 years who had suffered from transient global amnesia (TGA), were seen at the Department of Neurology, Pordenone Public Hospital, in period 1978 to 1982. 25 one or more risk factors for cerebrovascular disease, such as hypertension, cardiac abnormalities, diabetes hyperlipidemia. EEG examination revealed abnormal activity only 7 patients. Brain Computed Tomography showed cerebral atrophy 10 hypodense lesions 3 16 been followed up a mean interval 20 months....