A5026956027- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Pregnancy-related medical research
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Reproductive tract infections research
- Health Literacy and Information Accessibility
- Social Media in Health Education
- Patient-Provider Communication in Healthcare
- Ectopic Pregnancy Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Pelvic floor disorders treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Antimicrobial Peptides and Activities
- Uterine Myomas and Treatments
- Urological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Extracellular vesicles in disease
Hallym University
2014-2025
Hallym University Kangnam Sacred Heart Hospital
2015-2025
Hallym University Medical Center
2019-2023
Gachon University
2014
Yonsei University Health System
2008-2013
Yonsei University
2007-2012
University Health System
2011
Abstract Colposcopy is widely used to detect cervical cancers, but experienced physicians who are needed for an accurate diagnosis lacking in developing countries. Artificial intelligence (AI) has been recently computer-aided showing remarkable promise. In this study, we developed and validated deep learning models automatically classify neoplasms on colposcopic photographs. Pre-trained convolutional neural networks were fine-tuned two grading systems: the intraepithelial neoplasia (CIN)...
Globally, YouTube is one of the most popular websites, and content not restricted to entertainment. The purpose this study was assess quality information in videos pertaining hysterectomy.
Antimicrobial peptides, such as beta-defensin 2 (BD2), are vital in controlling infections and immune responses. In this study, we investigated the expression role of BD2 amniotic membrane human epithelial cells (hAECs) from patients with preterm birth chorioamnionitis, focusing on its regulation inflammatory cytokines protective effect barrier. Our results show increased Lipopolysaccharide (LPS)-induced inflammation release hAECs a dose- time-dependent manner. treatment effectively...
Abstract High mobility group box 1 (HMGB1) is a prototypic alarmin and plays an important role in the pathogenesis of inflammatory process spontaneous preterm birth. This study was conducted to compare levels HMGB1 amniotic fluid amnion membranes women with chorioamnionitis/intra-amniotic inflammation healthy controls. We also aimed elucidate involvement microRNA-548 (miR-548) regulating expression its function human epithelial cells (hAECs). A bioinformatics analysis predicted binding by...
Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, those that done so evaluated only a limited number amniotic fluid.A retrospective cohort study enrolled 71 patients undergoing physical examination-indicated cerclage to determine whether expanded fluid cytokine levels predict spontaneous very pre-term birth (≤32 weeks gestation) insufficiency. Analysis multiple was performed multiplex immunoassay.Sixty-seven samples were available for...
To assess the diagnostic accuracy of random urine protein-creatinine (P/C) ratio for prediction significant proteinuria in preeclampsia as an alternative to time-consuming 24-hour protein collection.Retrospective record analysis was performed on 140 pregnant women who were admitted with suspicion from January 2006 June 2011. Random and/or levels assessed and their correlation P/C excretion evaluated.Out patients, or/and 79 patients evaluate proteinuria. Of 46 (58%) underwent both tests...
YouTube is one of the most popular open-access video-sharing websites, and it also used to obtain health care information. Cesarean delivery common major surgical intervention in many countries. Videos related cesarean have been uploaded YouTube. However, no study has explored overall quality videos on platform.The objective this was analyze content evaluate frequently viewed that are accessible YouTube.We searched for a total 18 terms by combining 6 retrieved from Google AdWords 3 c...
Objective Our hospital's policy is to perform history-indicated cerclage (HIC) for pregnant patients with 1 or more second-trimester pregnancy losses. Recently, the American College of Obstetricians and Gynecologists (ACOG) guideline regarding indications HIC was changed from 3 previous fetal losses one more. In this study, we aimed evaluate efficacy revised investigate association between preterm history outcome. Methods We conducted a retrospective observational study cases in singleton...
A Case of
Epidemiologic studies have shown an association between tuberculosis and lung cancer. The al-tered tumor microenvironment after infection appears to contribute cancer pro-gression. Pleural effusions are enriched in exosomes, which act as mediators of intercellular communication. We hypothesized that tuberculous pleural effusion (TPE)-derived exosomes mediate Then we examined the interaction TPE-derived cells. Exosomal miRNA profiling TPE was performed using a microRNA array. An vitro cell...
Maternal hyperglycemia, induced by gestational diabetes mellitus (GDM), has detrimental effects on fetal vascular development, ultimately increasing the risk of cardiovascular diseases in offspring. The potential underlying mechanisms through which these complications occur are due to functional impairment and epigenetic changes endothelial progenitor cells (EPCs), remain less defined. We confirm that intrauterine hyperglycemia leads impaired angiogenic function EPCs, as observed assays...
Cervical insufficiency (CI) is associated with intra-amniotic infection or inflammation. Antimicrobial peptides (AMPs) in amniotic fluid may protect the fetus against microbial invasion, giving their broad-spectrum microbiocidal properties. We evaluated changes AMP expression women CI and assessed whether these are related to pregnancy outcomes.We human neutrophil peptide 3 (HNP-3), β-defensin-2 (hBD-2), LL-37 levels 66 25 normal controls at 16-24 weeks of gestation. The group was divided...
Transabdominal cerclage (TAC) is reported to be effective for preventing preterm birth in women with unsuccessful transvaginal (TVC) history. However, TAC has rarely been performed twin pregnancy given the lack of sufficient evidence and technical difficulty operation. Thus, it unclear whether an procedure a history TVC. The aim this study compare characteristics outcomes after versus singleton pregnancy, examine risk factor very (before 32 weeks) TAC, determine pregnancy. This single-center...
The uterine cervix is a mechanical and immunological barrier against ascending infection during pregnancy. Cervical insufficiency (CI), painless cervical dilation that occurs in the mid-trimester, an important cause of extremely preterm birth. We hypothesized women with CI have differential transcriptomic profile. Therefore, we compared profile peripheral blood controls.RNA sequencing was used to generate global gene expression profiles 11 4 controls, analysis performed identify genes...
Introduction: Intra-uterine infection is a major cause of spontaneous pre-term birth before 30 weeks gestation. In addition, intra-amniotic inflammation present in approximately 80 % patients with acute cervical insufficiency. The microbiome known to causing birth. Recently, surveys the microbial communities vagina or amniotic fluid using sequencing 16s rRNA gene have been carried out. Here, we reported compositions mid-trimester fluids two pregnant women insufficiency identified 16S...
Maternal hyperglycemia, induced by gestational diabetes mellitus (GDM), has detrimental effects on fetal vascular development, ultimately increasing the risk of cardiovascular diseases in offspring. The potential underlying mechanisms which these complications occur are through functional impairment and epigenetic changes endothelial progenitor cells (EPCs), however, remain less defined. We confirm that intrauterine hyperglycemia leads to impaired angiogenic function EPCs, as observed assays...
Background: Preterm birth (PTB) is a significant challenge in contemporary obstetrics, affecting over one ten infants worldwide and accounting for 75% of perinatal mortality. Short cervical length during mid-trimester well known to be associated with an increased risk spontaneous preterm (sPTB). Ultrasound-indicated cerclage (UIC) recommended prevent sPTB women short cervix at history sPTB. Objectives: This retrospective observational study aimed examine the impact diabetes obesity on...
Epidemiologic studies have shown an association between tuberculosis and lung cancer. The altered tumor microenvironment after infection appears to contribute cancer progression. Pleural effusions are enriched in exosomes, which act as mediators of intercellular communication. We hypothesized that tuberculous pleural effusion (TPE)-derived exosomes mediate Then, we examined the interaction TPE-derived cells. Exosomal miRNA profiling TPE was performed using a microRNA array. An vitro cell...
To evaluate the distribution of fetal frontomaxillary facial (FMF) angle at in normal Korean population 11 + 0 to 13 6 weeks gestation. Three-dimensional (3D) volumes head were obtained from low risk singleton pregnancies who consented this prospective study. Only cases with either a karyotype confirmed on amniocentesis or delivered live infant considered eligible for analysis. Those multiple pregnancies, anomaly utero postnatal, abnormal karyotyping, and loss-to-follow up excluded The FMF...
Uterine arteriovenous malformation (AVM) is associated with a risk of massive uterine bleeding. Although artery embolization remains the first-line treatment for AVM, there has been recent exploration pharmacological options. Danazol known to reduce blood flow uterus; however, our understanding its therapeutic efficacy AVM limited. Herein, we present results danazol use in patients AVM. We retrospectively reviewed medical records who received between January 2013 and November 2022. The...