A5101421509- Phytochemical Studies and Bioactivities
- Traditional and Medicinal Uses of Annonaceae
- Radiomics and Machine Learning in Medical Imaging
- Natural product bioactivities and synthesis
- Magnolia and Illicium research
- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Carbohydrate Chemistry and Synthesis
- Cerebral Venous Sinus Thrombosis
- Neurological Complications and Syndromes
- Gastrointestinal Tumor Research and Treatment
- Macrophage Migration Inhibitory Factor
- Synthesis of Organic Compounds
- Oxidative Organic Chemistry Reactions
- AI in cancer detection
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Sesame and Sesamin Research
- Advanced Proteomics Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Bioactive natural compounds
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Sarcoma Diagnosis and Treatment
Catholic University of Korea
2020-2024
Gachon University
2017-2024
Seoul St. Mary's Hospital
2021-2024
Incheon Medical Center
2017
Seoul National University
2011
Abstract Colposcopy is widely used to detect cervical cancers, but experienced physicians who are needed for an accurate diagnosis lacking in developing countries. Artificial intelligence (AI) has been recently computer-aided showing remarkable promise. In this study, we developed and validated deep learning models automatically classify neoplasms on colposcopic photographs. Pre-trained convolutional neural networks were fine-tuned two grading systems: the intraepithelial neoplasia (CIN)...
Abstract Background Exosomal miRNAs regulate gene expression and play important roles in several diseases. We used exosomal miRNA profiling to investigate diagnostic biomarkers of epithelial ovarian cancer (EOC). Methods In total, 55 individuals were enrolled, comprising healthy ( n = 21) EOC subjects 34). Small mRNA (smRNA) sequencing real-time PCR (RT-PCR) performed identify potential biomarkers. Receiver operating characteristic (ROC) curves conducted determine biomarker sensitivity...
Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is feature several conditions, including wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy prematurity. Development novel antiangiogenic small molecules for the treatment neovascular disease essential to provide new therapeutic leads these diseases. We have previously reported potential anti-angiogenic homoisoflavanone derivatives with efficacy in retinal choroidal...
Hypertension and endothelial dysfunction are associated with various cardiovascular diseases. Hydrogen sulphide (H2 S) produced by cystathionine γ-lyase (CSE) promotes vascular relaxation lowers hypertension. Honokiol (HNK), a natural compound in the Magnolia plant, has been shown to retain multifunctional properties such as anti-oxidative anti-inflammatory activities. However, potential role of HNK regulating CSE hypertension remains largely unknown. Here, we aimed demonstrate that...
Homoisoflavonoids are in the subclass of larger family flavonoids but have one more alkyl carbon than flavonoids. Among them, 5,7,8-trioxygenated homoisoflavonoids not been extensively studied for synthesis and biological evaluation. Our current objective is to synthesize 2 chroman-4-ones 12 that isolated from plants Bellevalia eigii, Drimiopsis maculata, Ledebouria graminifolia, Eucomis autumnalis, punctata, pallidiflora, Chionodoxa luciliae, Muscari comosum, Dracaena cochinchinensis. For...
Naturally occurring homoisoflavonoids isolated from some Liliaceae plants have been reported to diverse biological activities (e.g., antioxidant, anti-inflammatory, and anti-angiogenic effects). The exact mechanism by which homoisoflavonones exert anti-neuroinflammatory effects against activated microglia-induced inflammatory cascades has not well studied. Here, we aimed explore the of homoisoflavonoid SH66 having a potential anti-inflammatory effect in lipopolysaccharide (LPS)-primed BV2...
To introduce our novel technique for myometrial defect closure after adenomyomectomy. A retrospective cohort study. total of 40 patients with adenomyosis who visited clinic between October 2012 and January 2018 were recruited. Of those 34 eligible analysis. The mean thickness the affected uterine wall before surgery was 4.02 cm ± 1.11, dropping to 2.37 0.84 postoperatively. This led a drop 41% in wall, which found be significant using paired t-test (p < 0.0001). preoperative pain score 8.68...
Honokiol, a biphenolic neolignan isolated from Magnolia officinalis, was reported to have promising anti-inflammatory activity for the treatment of various diseases. There are many efforts on synthesis and structure-activity relationship honokiol derivatives. However, regioselective O-alkylation remains challenge serves as tool provide not only some derivatives but also chemical probes target identification mode action. In this study, we examined reaction condition O-alkylation, in which C2...
Ovarian cancer (OC) is the most lethal gynecologic malignancy and in-time diagnosis limited because of absence effective biomarkers. Germline BRCA1/2 genetic alterations are risk factors for hereditary OC; risk-reducing salpingo-oophorectomy (RRSO) pursued disease prevention. However, not all healthy carriers develop disease. Therefore, identifying predictive markers in carrier population could help improve identification candidates preventive RRSO. In this study, plasma samples from 20 OC...
Chemoselective controls in acylation of 2-amino-8-quinolinol.
Abstract The diastereodivergent synthesis of syn ‐ and anti ‐9‐hydroxyhomoisoflavanone from various chromones carbaldehydes is described. synthetic approaches involving the reductive aldol reaction or Morita‐Baylis‐Hillman followed by ‐selective 1,4‐reduction provide both diastereomers β ‐hydroxy chroman‐4‐ones in 51–98% yield with (2 : 1–16 1 / ) 22–80% (5 1–48 diastereoselectivity. ambiguity surrounding stereochemistry two 9‐hydroxyhomoisoflavanones, homoferrugenone portulacanone F was...
Dracaeconolide B (1), a naturally occurring homoisoflavane, was isolated from the red resin of Dracaena cochinchinensis. Efforts have been made to elucidate exact structure compound 1 since it confirmed that dracaeconolide did not contain 7-hydroxy-5,8-dimethoxy moiety. The revised by synthesis three homoisoflavanes containing 5,6,7-trioxygenated moiety each and analysis NMR spectroscopy. proposed as 3-(4-hydroxybenzyl)-7-hydroxy-5,6-dimethoxychromane. Noyori's Ru-catalyzed asymmetric...