The first assortment of achiral pentafluorosulfanylated cyclobutanes (SF

Abstract While numerous studies pertaining to the total synthesis of Cephalotaxus alkaloids have been reported, only two strategies reported date for successful C‐11 oxygenated subset, due additional synthetic challenge posed by remote stereocenter. Herein, we report collective asymmetric using a chiral proline both as starting material and chirality source. A tetracyclic advanced intermediate was synthesized in highly stereoselective manner from l ‐proline 8 steps involving sequential...

// Soo Young Cho 1, * , Minhye Choi 2, Hyo-Jeong Ban 3, 4, Chang Hyeon Lee 5 Soojun Park 6 HanKyeom Kim 2 Young-Sik Seek 3 Ji-Yun 1 Laboratory of Developmental Biology and Genomics, College Veterinary Medicine, Research Institute for Science BK21, Program Science, Seoul National University, 08826, Republic Korea Department Pathology, 02841, Division Molecular Life Sciences, Hanyang Ansan 15588, 4 Bio-Medical Informatics, Center Genome Health, Centers Disease Control Prevention,...

As transformed to aging society, many personal devices for healthcare have recently been developed. According the increase of individual development health devices, ISO/IEEE 11073 PHD standard is established gathering measurement data. But existing are not standardized. In this paper, we propose implementation model standardization legacy which do follow standard. We develop universal Adapter (UPA) and UPA interface board (non-PHD) device home service. Using system, communicate with manager...

Little is known about the relationship between miRNA and mRNA expression in Alzheimer's disease (AD) at early- or late-symptomatic stages. Sequence-based target prediction algorithms anti-correlation profiles have been applied to predict targets using omics data, but this approach often leads false positive predictions. Here, we joint profiling analysis of levels Tg6799 AD model mice 4 8 months age a network topology-based method. We constructed gene regulatory networks used PageRank...

A transition-metal-free 5-exo-dig asymmetric cyclization of α-amino ester enolates onto bromoalkynes provided a product with excellent enantioselectivity via the memory chirality concept. This strategy was applied to concise total synthesis (−)-runanine and formal (−)-8-demethoxyrunanine (−)-cepharatine D.

Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is feature several conditions, including wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy prematurity. Development novel antiangiogenic small molecules for the treatment neovascular disease essential to provide new therapeutic leads these diseases. We have previously reported potential anti-angiogenic homoisoflavanone derivatives with efficacy in retinal choroidal...

(1) Background: Pressure ulcers (PUs) substantially impact the quality of life spinal cord injury (SCI) patients and require prompt intervention. This study used machine learning (ML) techniques to develop advanced predictive models for occurrence PUs in with SCI. (2) Methods: By analyzing medical records 539 SCI, we observed a 35% incidence during hospitalization. Our analysis included 139 variables, including baseline characteristics, neurological status (International Standards...

We propose an activity recognition system especially for the elderly using a wearable sensor module including triaxial accelerometer. have mainly tackled easy battery loss problem minimizing efficiency decrease of recognition. The proposed consists main modules; module, gateway, and PDA phone. is worn at left side waistband, embedded algorithm installed in microcontroller manipulates sensing data order to reduce transferring overhead which causes enormous loss. After that, transfers them...

An efficient strategy for the asymmetric synthesis of Cα-tetrasubstituted proline derivatives from has been established. A nitrogen-fused bicyclic system was devised to control stereodynamics proline. Through N-quaternizations with allylic electrophiles followed by [2,3]-rearrangements, delivered enantioenriched prolines. This applied concise total (−)-amathaspiramide F.

Abstract Asymmetric synthesis of α‐substituted proline derivatives has been accomplished by an efficient chirality‐transfer method. High diastereoselectivity the N‐alkylation ester (C→N chirality transfer) was achieved when a 2,3‐disubstituted benzyl group used as N‐substituent. DFT calculations provided mechanistic rationale for high degree stereoselectivity. The generated N‐chirality quaternary ammonium salt transferred back to α‐carbon through stereoselective [2,3]‐Stevens rearrangement...

Deuterium-labeled α-amino acids are useful in research related to drug discovery and biomedical science. However, a high degree of site selectivity stereoselectivity the deuterium incorporation process is still difficult achieve. Herein, we report new enantioselective deuteration method at α-position several amino without external chiral sources. The proposed methods (NaOEt EtOD) highly selective simple. Additionally, provide mechanistic study for this enantioretentive deuteration.

This paper is concerned about a medication reminding service in home environments and its context reasoning method to recognize the suitable for situation. To provide an appropriate depending on user's situation, it needed model infer based condition. In this paper, we proposed organizing engine service. We used jess rule build our suggested resolving avoid conflict caused by similar invoke conditions.

A base-mediated aerobic oxidative cleavage of α-amino esters involving a hydroperoxide intermediate was reported, which represents the first example α-C–N bonds amino acid derivatives without aid metal catalysts.

Abstract An efficient and facile synthesis of highly substituted pyridinium salts through the annulation enamines with alkynes is reported herein. A Ag 2 CO 3 /HNTf synergistically acting catalyst system was developed used in a condensation reaction between carbonyl substrates propargylamine to afford structurally diverse salts. mechanistic investigation shows that this one‐pot transformation proceeded via selective 6‐ endo ‐ dig cyclization situ generated propargylenamine protonolysis...

As transformed to aging society, many personal devices for healthcare have recently been developed. According the increase of individual development health devices, ISO/IEEE 11073 PHD standard is established gathering measurement data. But existing are not standardized. In this paper, we propose implementation model standardization which do follow standard. We use Nintendo's Wii Balance board as weighting scale and develop virtual weight agent standardization. It communicates gateway...

Abstract While numerous studies pertaining to the total synthesis of Cephalotaxus alkaloids have been reported, only two strategies reported date for successful C‐11 oxygenated subset, due additional synthetic challenge posed by remote stereocenter. Herein, we report collective asymmetric using a chiral proline both as starting material and chirality source. A tetracyclic advanced intermediate was synthesized in highly stereoselective manner from l ‐proline 8 steps involving sequential...

An efficient strategy for the asymmetric synthesis of Cα-substituted proline derivatives from acyclic α-amino acids has been established. The 5-exo-dig cyclization ester enolates onto heterosubstituted alkynes provided a product with excellent enantioselectivity via memory chirality concept. Density functional theory calculations indicated that heteroatom is crucial success because more stabilized vinyl carbanion produced. This new method potential to enable rapid construction bioactive...

Abstract An efficient asymmetric synthetic approach for the synthesis of Cα‐substituted pipecolic acid has been investigated through utilizing an N‐fused bicyclic system. Despite fluxionality imidazolidinone, N‐alkylation proceeded in high yield with excellent selectivity. The subsequent [2,3]‐Stevens rearrangement afforded derivatives successfully. computational study revealed that diastereoselectivity during is governed by Curtin‐Hammett kinetics.

Compared to related electrophilic species, O-acyloxocarbenium ions (AOIs) have been much less utilized in organic synthesis due the lack of an efficient formation method. Here, we present a facile and simple approach for generation AOI from ester acetal groups. Based on our system with pendant nucleophile, obtained unique bridged bicyclic via epoxonium-like transition state. The proposed mechanism is based experimental computational studies.

Abstract Our first strategy for rapidly accessing pyrrolidinone cores of salinosporamides involved combined use memory chirality and dynamic kinetic resolution principles in aldol reactions the serine‐derived 5‐oxazolidinone substrate, which was ultimately unsuccessful with respect to enantioselectivity. This failure led us revised strategy. The influence stereocenter enabled selective installation C‐2 stereocenter. intramolecular reaction stereodefined substrate successful. An unexpected...