A5101511295- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Vitamin C and Antioxidants Research
- S100 Proteins and Annexins
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Immune Response and Inflammation
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Climate Change and Health Impacts
- Genomics, phytochemicals, and oxidative stress
- Non-Invasive Vital Sign Monitoring
- Tryptophan and brain disorders
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Consumer Perception and Purchasing Behavior
- Nosocomial Infections in ICU
- Diverse Topics in Contemporary Research
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Neuroscience and Neuropharmacology Research
Seoul National University Hospital
2012-2024
Seoul National University
2020-2023
Seoul National University Bundang Hospital
2017
Boramae Medical Center
2017
Seoul Metropolitan Government
2017
Namseoul University
2017
National Medical Center
2014-2015
OBJECTIVES: Frailty is a multidimensional syndrome or state of increased vulnerability to poor resolution homoeostasis following stressor event. common in patients with sepsis. Sepsis and frailty are both associated older age chronic medical conditions. However, there limited evidence about the direct association between The aim this study determine preexisting clinical outcomes DESIGN: A nationwide propensity score–matched cohort analyzing data prospectively collected September 2019...
To investigate whether 48 hours of therapeutic hypothermia is more effective to attenuate brain apoptosis than 24 and determine the antiapoptotic effects are associated with suppressions cleavage protein kinase C-δ, cytosolic release cytochrome c, caspase 3 in a swine cardiac arrest model.Prospective laboratory study.University laboratory.Male domestic pigs (n = 24).After 6 minutes no-flow time that was induced by ventricular fibrillation, cardiopulmonary resuscitation provided, return...
Significance Septic shock commonly leads to multiorgan injury both directly via tissue inflammation and secondarily hypoperfusion, but can result in mitochondrial N -formyl peptide (mtFP) release into the circulation. However, no studies have evaluated role of circulating mtFPs during septic shock. We found that a relatively high plasma nicotinamide adenine dinucleotide dehydrogenase subunit-6 (the most potent human mtFP) level was independently associated with development secondary...
Abstract The purpose of study was to evaluate that kallistatin deficiency causes excessive production reactive oxygen species and exacerbates neuronal injury after cardiac arrest. For in vitro study, knockdown human cells were given ischemia–reperfusion injury, the oxidative stress apoptosis evaluated. clinical arrest survivors admitted ICU divided into good (CPC 1–2) poor 3–5) 6-month neurological outcome groups. serum level kallistatin, Nox-1, H 2 O measured. Nox-1 levels increased with (p...
To determine whether the combination therapy of niacin and selenium attenuates lung injury improves survival during sepsis in rats its benefits are associated with activation glutathione redox cycle up-regulation nuclear factor erythroid 2-related 2.Prospective laboratory study.University laboratory.Human microvascular endothelial cells male Sprague-Dawley (n = 291).In lipopolysaccharide-exposed cells, dose-related effects were assessed, therapeutic (0.9 mM) (1.5 μM) evaluated. The role 2...
The purpose of the current study was to investigate protective effect niacin on acute lung injury by down-regulation nuclear factor κB (NF-κB) pathway in hemorrhagic shock (HS) rats.HS induced male Sprague-Dawley rats withdrawing blood maintain a mean arterial pressure 20 mm Hg 25 for 40 minutes. were resuscitated reinfusion drawn blood, and vehicle (HS), low-dose (360 mg/kg, HS + LD-NA), or high dose (1,080 HD-NA) administered orally. survival subjects observed 72 hours, separate set...
Abstract Sex differences in the in-hospital management of sepsis exist. Previous studies either included patients with that was defined using previous definitions or evaluated 3-h bundle therapy. Therefore, this study sought to assess sex 1-h therapy and among septic shock, according Sepsis-3 definitions. This observational used data from Korean Shock Society (KoSS) registry, a prospective multicenter registry. Adult between June 2018 December 2021 were study. The primary outcome adherence...
Abstract During recovery from septic shock, circulating mitochondrial N-formyl peptides predispose to secondary infection by occupying formyl peptide receptor 1 on the neutrophil (polymorphonuclear leukocyte) membrane, suppressing cytosolic calcium ([Ca2+]i)-dependent responses secondarily encountered bacteria. However, no study has yet investigated therapeutic clearance of in clinical settings. Thus, we studied how remove septic-shock plasma and whether such removal could preserve...
We performed this study to establish a prediction model for 1-year neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients who achieved return of spontaneous circulation (ROSC) immediately after ROSC using machine learning methods.We retrospective analysis an OHCA survivor registry. Patients aged ≥ 18 years were included. Study participants had registered between March 31, 2013 and December 2018 divided into develop dataset (80% total) internal validation (20% total), those...
To determine neuroprotective effects and mechanism of the combination therapy niacin selenium in cardiac arrest rats.Prospective laboratory study.University laboratory.Rat cortex neurons male Sprague-Dawley rats (n = 68).In rat underwent 90 minutes oxygen-glucose deprivation 22.5 hours reoxygenation, (0.9 mM) (1.5 μM) were investigated. The role DJ-1 was determined using knockdown cells. In rats, posttreatment (360 mg/kg) (60 μg/kg) evaluated.In reoxygenation cells, synergistically activated...
To investigate whether regional cerebral oxygen saturation (rSO2) differs in out-of-hospital cardiac arrest (OHCA) survivors undergoing targeted temperature management (TTM) 36 °C versus 33 °C.A randomized clinical trial was conducted at intensive care units two referral hospitals. Fifty-seven comatose OHCA were into either a or group. Patients cooled and maintained an oesophageal of for 24 hours, rewarmed rate 0.25 °C/hour, <37.5 until 72 hours. During hours TTM, rSO2 continuously monitored...
We aimed to compare the multi-marker strategy (copeptin and high-sensitivity cardiac troponin I [hs-cTnI]) with serial hs-cTnI measurements rule out acute myocardial infarction (AMI) in patients chest pain.This prospective observational study was performed a single emergency department. To test non-inferiority margin of 4% terms negative predictive value (NPV) between (0 hour) 2 hours), 262 participants were required. Samples for copeptin assays collected at presentation after hours. The...
Target temperature management (TTM) improves neurological outcomes for comatose survivors of out-of-hospital cardiac arrest. We compared the efficacy and safety a gel pad cooling device (GP) water blanket (WB) during TTM.We performed retrospective analysis in single hospital, wherein we measured time to target (<34℃) after initiation evaluate effectiveness method. The farthest from 33℃ was selected every hour maintenance. Generalized estimation equation used compare absolute differences...