A5102774176- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Neutropenia and Cancer Infections
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Palliative Care and End-of-Life Issues
- Nursing Roles and Practices
- Health and Wellbeing Research
- Patient Dignity and Privacy
- Clinical practice guidelines implementation
- Healthcare Education and Workforce Issues
- Herpesvirus Infections and Treatments
- Bone Metabolism and Diseases
- Blood disorders and treatments
- Diverse Approaches in Healthcare and Education Studies
- Hematological disorders and diagnostics
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Ethics in medical practice
University of Ulsan
2014-2024
Ulsan College
2013-2024
Asan Medical Center
2013-2024
Korea National Institute of Health
2011
Korea Center for Disease Control and Prevention
2010
Korea Disease Control and Prevention Agency
2010
Background/Aims: Cytomegalovirus (CMV) surveillance and preemptive therapy is a widely-used strategy for preventing CMV disease in transplant recipients. However, there are limited data on the incidence patterns of during period. Thus, we investigated pattern tissue-invasive seropositive kidney transplantation (KT) hematopoietic stem cell (HCT) recipients therapy. Methods: We prospectively identified patients with among 664 KT (90%) 496 HCT (96%) who were D+/R+ (both donor recipient...
Purpose:The purpose of the study was to describe experiences do-not-resuscitate (DNR) among nurses.Methods: Data were collected by in-depth interviews with 8 nurses in different hospitals.Conventional qualitative content analysis used analyze data.Results: Eight major themes emerged from analysis: DNR decision-making bypassing patient, inefficiency process DNR, negative connotation predominance verbal over written doubts and confusion about least amount intervention decision for change focus...
Efforts to overcome poor outcomes in patients with adult acute lymphoblastic leukemia (ALL) have focused on combining new therapeutic agents targeting immunophenotypic markers (IPMs) classical cytotoxic agents; therefore, it is important evaluate the clinical significance of IPMs.Baseline characteristics and ALL were retrospectively analyzed. The percentage blasts expressing IPMs at diagnosis was measured by multicolor flow cytometry analysis. Samples which ≥20% expressed an IPM considered...
Abstract Background Nurses frequently encounter ethically challenging situations in everyday practice. In these situations, nurses often know an appropriate course of action to take but are unable do so. Many studies have examined the faced by nurses, how cope with is not well understood. Therefore, this study aims explore coping strategies used or adopted expert South Korea. Methods Participants were recruited via purposive sampling. Small group interviews conducted 26 registered a general...
Abstract The impact of reduced‐intensity conditioning (RIC) on the outcomes hematopoietic cell transplantation (HCT) from unrelated ‐donors (UD) remains to be determined. We therefore assessed 128 patients, aged 16 66 years, with acute leukemia ( n = 105) or myelodysplastic syndrome 23) in a UD‐HCT trial using RIC busulfan, fludarabine, and antithymocyte globulin. Patients were transplanted unmanipulated bone marrow (BM, 41) mobilized peripheral blood mononuclear cells (M‐PB, 87) received...
Purpose This study aimed to propose a common scope of practice (SOP) for 13 specialties Advanced Practice Nurses (APNs) in Korea. Methods The first draft SOP was extracted from domestic and international laws with literature review by 17 experts the Korean Association (KAAPN). Then, finalized after comparing activities APNs clinical settings. Results A total 70 duties were identified six categories suggested SOP. proposed KAAPN featured following: 1) identification discrimination between...
This study presents outcomes of management in graft failure (GF) after allogeneic hematopoietic stem cell transplantation (HCT) and provides prognostic information including rare cases autologous reconstitution (AR).We analyzed risk factors primary secondary GF, occurrence AR 1,630 HCT recipients transplanted over period 18 years (January 2000-September 2017) at our center.Primary GF occurred 13 (0.80%), 69 patients (10-year cumulative incidence, 4.5%) respectively. No peri-transplant...
This study aimed to investigate the nationwide intention delegate clinical practice of medical specialists in accordance with enactment scope for advanced nurses (APNs).Data were collected from October December 2021 using Google Surveys. In total, 147 12 provinces responded survey. The survey questionnaire was categorized into four legislative draft duties, according (a total 41 tasks): Twenty-nine tasks on treatments, injects, etc., performed under guidance a physician and other activities...
Acute graft-versus-host disease (GVHD) usually occurs with neutrophil engraftment following allogeneic hematopoietic cell transplantation (HCT), but it can also occur before engraftment. We intended to analyze the effects of timing acute GVHD on leukemia relapse and mortality.The outcomes pre- postengraftment were investigated in 384 patients who underwent HCT for leukemia.Acute occurred 100 patients, pre-engraftment 22 78. Compared GVHD, was more severe, as assessed by overall grade,...
Abstract The prognosis of patients with acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation (HSCT) is dismal. We aimed to evaluate the outcomes and prognostic factors second HSCT (HSCT2) in first (HSCT1). analyzed 80 who received HSCT2 for two Korean institutes. All but four from a donor other than matched sibling donor: an unrelated (URD) 30 familial haploidentical (FHD) 46. Forty‐four (55.0%) were complete remission (CR) or CR incomplete count recovery (CRi) at...
Scoring systems developed for predicting survival after allogeneic hematopoietic cell transplantation (HCT) show suboptimal prediction power, and various factors affect posttransplantation outcomes.A model using a machine learning-based algorithm can be an alternative concurrently applying multiple variables reduce potential biases. In this regard, the aim of study is to establish validate predictive HCT in patients with hematologic malignancies.Data from 1470 malignancies who underwent...
The detailed kinetics of the cytomegalovirus (CMV)-specific T cell response in hematopoietic stem transplant (HCT) recipients have not yet been fully assessed.We evaluated these CMV-specific and factors associated with high responses 1 year after HCT.In HCT recipients, CMV pp65 IE1-specific ELISPOT assay were performed before (D0), at 30 (D30), 90 (D90), 180 (D180), 360 (D360) days HCT.Of 51 donor-positive (D + )/recipient-positive (R ) serology, 26 (51%) developed infections HCT.The...
Although allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment option for myelodysplastic syndrome (MDS), a substantial number of patients experience relapse. We reviewed clinical outcomes with MDS who relapsed after HCT.Thirty experienced relapse or progression HCT between July 2000 and May 2016 were included in this retrospective analysis.The median time from to was 6.6 (range, 0.9-136.3) months. Donor lymphocyte infusions (DLIs) administered four patients: one...
Treatment with 3-6 cycles of PS-341/bortezomib, adriamycin, and dexamethasone (PAD) has been explored in terms induction therapy prior to autologous stem cell transplantation (ASCT) patients multiple myeloma (MM). We evaluated the effects two PAD given before ASCT.Patients received 21-d (bortezomib 1.3 mg/m(2) × 4 d, adriamycin 9 40 mg d 2). Starting on day 12 cycle 2, were subcutaneous granulocyte-colony stimulating factor mobilize peripheral blood cells (PBSCs). Following PBSC harvesting,...
For patients with lower-risk myelodysplastic syndrome (MDS), treatment primarily aims to decrease cytopenia-related complications, avoid transfusions and sustain the quality of life. Although erythroid-stimulating agents (ESAs), lenalidomide, immunosuppressive therapy hypomethylating (HMAs) can be used in selected groups patients, limited number who respond these treatments likelihood treatment-related worsening cytopenia are major barriers treating MDS. Historically, androgens have been for...