A5076725309- Cytomegalovirus and herpesvirus research
- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Infectious Encephalopathies and Encephalitis
- Psoriasis: Treatment and Pathogenesis
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 and COVID-19 Research
- Botulinum Toxin and Related Neurological Disorders
- SARS-CoV-2 detection and testing
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Clostridium difficile and Clostridium perfringens research
- Diabetic Foot Ulcer Assessment and Management
- Fungal Infections and Studies
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Mosquito-borne diseases and control
Montefiore Medical Center
2024-2025
Albert Einstein College of Medicine
2024-2025
Columbia University Irving Medical Center
2020-2022
Columbia University
2021
Memorial Sloan Kettering Cancer Center
2015-2018
It remains uncertain whether immunocompromised patients including solid organ transplant (SOT) recipients will have a robust antibody response to SARS-CoV-2 infection. We enrolled all adult SOT at our center with confirmed infection who underwent testing single commercially available anti-nucleocapsid test least 7 days after diagnosis in retrospective cohort. Seventy were studied (56% kidney, 19% lung, 14% liver ± and 11% heart kidney recipients). Thirty-six (51%) had positive testing, 34...
Abstract Background Infections in solid organ transplant (SOT) recipients continue to be a clinical challenge despite modern diagnostics. Autopsies have the potential identify missed infectious diagnoses thereby informing practice of diseases. We sought evaluate value autopsies by analyzing pre-and post-mortem deceased SOT recipients. Methods retrospectively reviewed adult who underwent at our institution from January 2017 December 2022. Electronic medical chart review these was conducted...
Abstract Background Cytomegalovirus (CMV) disease is known to affect morbidity and mortality after solid organ transplant (SOT). However, less concerning low-level CMV viremia (llCMV) (< 1000 IU/ml). Having llCMV the decision treat with antivirals may be associated changes in long-term graft outcomes SOT. We aimed review patient-level of SOT our large urban academic medical center. Methods performed a retrospective patients from Montefiore Medical Center who underwent heart, liver,...
Abstract Background Diabetic foot infections (DFIs) are a significant cause of morbidity in kidney transplant recipients (KTRs) with underlying diabetes. While empiric antibiotic coverage an antipseudomonal is common practice, recent studies DFIs non-transplant patients have found relatively low prevalence Pseudomonas aeruginosa (PSA). We hypothesize that the PSA also among KTRs. Organisms isolated cultures from diabetic (DFI) (KTR) Methods performed review all positive microbiologic...
Recipients of ex vivo T cell–depleted (TCD) hematopoietic cell transplantation (HCT) are at risk infection by double-stranded (ds) DNA viruses. We report rates dsDNA viremia, end-organ disease (EOD), infection-related mortality, and overall survival (OS) in a contemporary cohort adult TCD HCT recipients routinely monitored for cytomegalovirus (CMV), adenovirus (ADV), human herpesvirus 6 (HHV6), Epstein-Barr virus (EBV). Healthcare utilization the first months post-HCT was compared between...
Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) is highly effective. However, people who inject drugs face significant barriers to DAA access.We describe a program that colocates HCV management within syringe service in New York City. We performed retrospective chart review of all patients with confirmed viremia.From 2015 2018, 102 viremia completed intake. Fifty-eight started DAAs. Nine discontinued treatment or were lost follow-up before completion; 1 continuing...
Abstract Advancement in solid organ transplantation and hematopoietic stem cell transplant continues to improve the health outcomes of patients widens number eligible who can benefit from medical progress. Preserving effectiveness antimicrobials remains crucial, as otherwise surgeries would be unsafe due surgical site infections, risk sepsis with neutropenia preclude transplant. In this review, we provide updates on three previously discussed stewardship challenges: febrile neutropenia,...
We quantified cytomegalovirus (CMV) antiviral use and hospital length of stay (LOS) associated with CMV infection in a contemporary cohort conventional (CONV) CD34-selected (T cell-depleted) hematopoietic cell transplantation (HCT) recipients managed by preemptive therapy (PET) single US center. Adults who received first allogeneic HCT at Memorial Sloan Kettering Cancer Center from June 2010 through December 2014 were analyzed. Days on PET, number readmissions, readmission LOS day 180...
Abstract HIV transmission via solid organ transplant is a rare but serious complication. Here, we describe long‐term outcomes in case of living donor‐derived kidney recipient. After 11 years since surgery, the donor shows no evidence abnormal renal function, while recipient continues to have functioning graft. well controlled both individuals. This single report highlights possibility acceptable donors with as recipients.
CMV infection is common after HCT and adversely impacts outcomes. TCD by CD34+ selection associated with increased risk for infection. We analyzed a cohort of patients (pts) monitored quantitative polymerase chain reaction assay (qPCR) managed preemptively. report rates viremia disease at 1 year post HCT. also assessed the aggregate days (d) on antivirals, length hospital stay (LOS), mortality in first 100 d Adults acute leukemia (AL) myelodysplastic syndrome (MDS) who received from June...
Allogeneic hematopoietic cell transplant (HCT) recipients are at risk for HSV and VZV infections. Brincidofovir (BCV, CMX001), a lipid conjugate of cidofovir, is active in vitro against HSV/ VZV, but clinical experience supporting the use BCV prophylaxis (ppx) HSV/VZV lacking. From Jan 2010 through Jul 2015, 79 HCT patients (pts) MSK received clincial trials or single patient (SPU) double stranded (ds) DNA viruses. Concomitant acyclovir (ACV) was clinician’s discretion. We report our ppx....
CMV viremia is associated with adverse transplant outcomes despite preemptive therapy (PET). Establishing benchmarks for the burden of important optimal implementation novel strategies prevention. The objectives this study are to (1) quantify antiviral use and (2) impact on hospital length stay (LOS) in HCT treated a single center. Retrospective analysis adult CD34+ selected (TCD) or unmodified (CONV) peripheral blood patients at MSK from June 2010 through December 2014 leukemia,...
Abstract Background The long-term complications of COVID-19 infection in the general population include mortality, re-infection, secondary infection, persistent organ dysfunction, and symptoms long-COVID. prevalence these outcomes impact on graft function solid transplant (SOT) remain uncertain. We aim to describe a large series SOT with 2 years follow up. Methods retrospectively studied all adult (age >18) from single center hospitalized SARS-CoV-2 diagnosed by nasopharyngeal swab...