A5049549121- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Sarcoidosis and Beryllium Toxicity Research
- Spondyloarthritis Studies and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Viral Infections and Immunology Research
- Tendon Structure and Treatment
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Osteoarthritis Treatment and Mechanisms
- Polyomavirus and related diseases
- Eosinophilic Disorders and Syndromes
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diabetes and associated disorders
- Neutropenia and Cancer Infections
- Cardiovascular Function and Risk Factors
- Intramuscular injections and effects
- Signaling Pathways in Disease
National Jewish Health
2019-2024
University of Colorado Denver
2019-2024
Comenius University Bratislava
2024
University College London
2024
Universidade Nova de Lisboa
2024
European Society of Intensive Care Medicine
2020
NewYork–Presbyterian Hospital
2018-2019
Presbyterian Hospital
2018-2019
Columbia University
2013-2019
New York Hospital Queens
2018
Background: The goal of this study was to assess the prevalence myocardial microvascular dysfunction in rheumatoid arthritis (RA) patients without clinical cardiovascular disease and its association with RA characteristics measures cardiac structure function. Methods: Participants underwent rest vasodilator stress N-13 ammonia positron emission tomography echocardiography. Global blood flow quantified at during peak hyperemia. Myocardial reserve (MFR) calculated as flow/rest flow. A small...
Rising anti-double-stranded (ds) DNA titers have been shown by some, but not all, studies to be predictive of disease flares in systemic lupus erythematosus (SLE). We hypothesized that a rapid and substantial rise anti-dsDNA titer (anti-dsDNA surge) would good predictor clinically important SLE flare.A matched case-control study was conducted an academic rheumatology practice setting. Our primary endpoint the occurrence severe SELENA-SLEDAI (SS) flare within six months surge, secondary...
Objective To determine the prevalence and correlates of subclinical myocardial inflammation in patients with rheumatoid arthritis ( RA ). Methods (n = 119) without known cardiovascular disease underwent cardiac 18‐fluorodeoxyglucose FDG ) positron emission tomography computed PET ‐ CT Myocardial uptake was assessed visually measured quantitatively as standardized value SUV Multivariable linear regression used to assess associations patient characteristics s. A subset who had escalate their...
Hematopoietic stem cell transplant (HSCT) recipients are at significant risk for BK virus (BKV) reactivation, hemorrhagic cystitis (HC), and renal dysfunction. We prospectively monitored 98 patients who had received HSCT by serial BKV PCR in the urine through day (D) +100 to analyze relationship between viruria HC, serum creatinine (Cr), clearance (CrCl) D +180 or death. Patients, median age 52 years (range, 20 73), T cell-depleted (50%) cord blood allografts (21%). Median pre-HSCT IgG...
To explore the contributions from and interactions between articular swelling damage, psychosocial factors, body composition characteristics on walking speed in rheumatoid arthritis (RA).RA patients underwent timed 400-meter long-corridor walk. Demographics, self-reported levels of depressive symptoms fatigue, RA characteristics, (using whole-body dual X-ray absorptiometry, abdominal thigh computed tomography) were assessed their associations with explored.A total 132 had data for walk,...
Rheumatoid arthritis is an autoimmune disease that classically presents as a symmetrical inflammatory polyarthritis. Extra-articular manifestations are prevalent, with the lungs being most common site [1], and interstitial lung (ILD) severe form of pulmonary involvement. In some studies, median survival patients rheumatoid usual pneumonia (UIP) pattern on high-resolution computed tomography (HRCT) around 3 years (similar to in idiopathic fibrosis (IPF) [2, 3]); however, other >7 [4, 5]. When...
In phase I and II trials taxane chemotherapeutic agents reported side effects, including myelosuppression, peripheral edema, fluid retention. With further use of these agents, studies in the late 1980s early 1990s began to report neuropathy proximal muscle weakness as common complaints, later with unexplained pathophysiology. We a 65-year-old Hispanic woman estrogen receptor (ER) progesterone (PR) positive invasive ductal breast carcinoma who presented right thigh pain swelling eight days...
Rheumatoid arthritis (RA) is a common systemic autoimmune disease whose fibro-inflammatory manifestations may affect number of tissues and organs, including the lungs. In fact, interstitial lung (ILD) leading cause mortality among patients with RA. RA-related (RA-ILD) most often presents in an injury pattern called usual pneumonia (UIP), which portends relatively worse prognosis than other less commonly occurring patterns RA-ILD, like non-specific (NSIP). Biomarkers from serum or...
To investigate the frequency and factors associated with disease flare following vaccination against SARS-CoV-2 in people inflammatory/autoimmune rheumatic musculoskeletal diseases (I-RMDs). Data from European Alliance of Associations for Rheumatology Coronavirus Vaccine physician-reported registry were used. Factors patients I-RMDs investigated using multivariable logistic regression adjusted demographic clinical factors. The study included 7336 I-RMD, 272 (3.7%) experiencing flares 121...
There are limited data nationwide on the burden of systemic sclerosis (SSc)-related mortality. We aimed to determine recent trends in SSc and SSc-related pulmonary arterial hypertension (PAH) mortality overall across population subgroups. Using death certificate from National Center for Health Statistics, we computed age-adjusted rates SSc-SSc−PAH, a lethal prevailing complication, demographic groups, geographic regions comorbid cardiorespiratory conditions, used Joinpoint regression...
Background: Prior studies have demonstrated improved efficacy when intra-articular (IA) therapeutics are injected using ultrasound (US) guidance. The aim of this study was to determine if clinical improvement in pain and function after IA hyaluronic acid injections US is associated with changes SF volumes biomarker proteins at 3 months. Methods: 49 subjects symptomatic knee OA, BMI < 40, KL radiographic grade II or III participated. Subjects adequate aspirated synovial fluid (SF) received...
Abstract Background Diastolic dysfunction (DD) is more prevalent in patients with rheumatoid arthritis (RA) compared to the general population. However, its evolution over time and significant clinical predictors remain uncharacterized. We report on baseline prospective changes diastolic function associated RA cardiovascular (CV) predictors. Methods In this study, 158 without CV disease (CVD) were enrolled followed up at 4 6 years, undergoing follow-up echocardiography assess for DD, as well...
Morgenstern, Rachelle MPH; Amigues, Isabelle MD; Giles, Jon T. MD, Bathon, Joan M. Bokhari, Sabahat MD Author Information
Abstract Background: Diastolic dysfunction (DD) is more prevalent in patients with rheumatoid arthritis (RA) compared to the general population. However, its evolution over time and significant clinical predictors, remain uncharacterized. We report on baseline prospective changes diastolic function associated RA cardiovascular (CV) predictors. Methods: In this study, 158 without CV disease (CVD) were enrolled followed up at 4 6 years, undergoing followup echocardiography assess for DD, as...