A5041225979- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Antimicrobial Resistance in Staphylococcus
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cancer Immunotherapy and Biomarkers
- Chemotherapy-induced cardiotoxicity and mitigation
- Viral Infections and Immunology Research
- Otolaryngology and Infectious Diseases
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Phonocardiography and Auscultation Techniques
- Peptidase Inhibition and Analysis
- Takotsubo Cardiomyopathy and Associated Phenomena
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Pericarditis and Cardiac Tamponade
- CAR-T cell therapy research
- Ultrasound in Clinical Applications
Institute Mutualiste Montsouris
2023-2025
University College London
2012-2024
Inserm
2014-2024
Paris Cardiovascular Research Center
2014-2024
Universidade Nova de Lisboa
2024
Comenius University Bratislava
2024
European Hospital
2024
Assistance Publique – Hôpitaux de Paris
2013-2023
Université Paris Cité
2014-2023
Hôpital Européen Georges-Pompidou
2014-2023
AimTo identify the proportion and characteristics of patients with severe symptomatic mitral regurgitation (MR) who are denied surgery.
The considerable progress made in the field of cancer treatment has led to a dramatic improvement prognosis patients with cancer. However, toxicities resulting from these treatments represent cost that can be harmful short‐ and long‐term outcomes. Adverse events affecting cardiovascular system are one greatest challenges overall management cancer, as they compromise success optimal against tumor. Such adverse associated not only older chemotherapy drugs such anthracyclines but also many...
Objective: Myocarditis is a rare disease that may progress rapidly to refractory cardiogenic shock and death. In such situations, emergent initiation of mechanical circulatory assistance the only therapeutic option rescue these dying patients. This study was designed evaluate outcomes, health-related quality life frequencies anxiety, depression posttraumatic stress disorder symptoms in fulminant myocarditis patients rescued by assistance, since major components outcome evaluation after...
Objective: To describe the clinical spectrum of infective endocarditis in critically ill patients and assess impact neurologic complications on outcomes. Design: Prospective multicenter observational study conducted from April 2007 to October 2008. Setting: Thirty-three intensive care units 23 university-affiliated 10 general French hospitals. Patients: Two hundred twenty-five with definite IE were studied. Factors associated predictors 3-month mortality identified by logistic regression...
Haemodynamics alone do not fully explain symptoms and prognosis in clinically severe aortic stenosis (AS). Myocardial disease, specifically diffuse myocardial fibrosis (DMF), may contribute. We used equilibrium contrast cardiovascular magnetic resonance (EQ-CMR) sought to non-invasively measure DMF AS determine its clinical significance before after valve replacement. Patients with underwent echocardiography, brain natriuretic peptide (BNP), 6 min walk test (6MWT), EQ-CMR pre- (n = 63) at...
Abstract The indigenous populations of the South Pacific experience a high burden rheumatic heart disease (RHD). Here we report genome-wide association study (GWAS) RHD susceptibility in 2,852 individuals recruited eight Oceanian countries. Stratifying by ancestry, analysed genotyped and imputed variants Melanesians (607 cases 1,229 controls) before follow-up suggestive loci three further ancestral groups: Polynesians, Asians Mixed or other (totalling 399 617 controls). We identify novel...
<h3>Objective</h3> We hypothesised that abnormal global longitudinal strain (GLS) would predict outcome in hypertrophic cardiomyopathy (HCM) better than current echocardiographic measures. <h3>Methods</h3> Retrospective analysis of risk markers relation to outcomes 472 patients with HCM at a single tertiary institution (2006–2012). Exclusion criteria were left ventricular (LV) hypertrophy other origin, atrial fibrillation, lost follow-up and insufficient image quality perform analysis....
Background— Rheumatic heart disease (RHD) remains a major public health problem worldwide. Although early diagnosis by echocardiography may potentially play key role in developing active surveillance, systematic evaluation of simple approaches resource poor settings are needed. Methods and Results— We prospectively compared focused cardiac ultrasound (FCU) to reference approach for RHD screening school children population. FCU included (1) the use pocket-sized machine, (2) nonexpert staff (2...
Rheumatic heart disease affects more than 40.5 million people worldwide and results in 306,000 deaths annually. Echocardiographic screening detects rheumatic at an early, latent stage. Whether secondary antibiotic prophylaxis is effective preventing progression of unknown.
To assess long-term outcomes and the management of critical left-sided infective endocarditis (IE) evaluate impact surgery. Among 198 patients included prospectively for IE across 33 adult intensive care units (ICU) in France from 1 April 2007 to October 2008, 137 (69%) were dead at a median follow-up time 59.5 months. Characteristics significantly associated with mortality were: Sepsis-related Organ-Failure Assessment (SOFA) score ICU admission [Hazard ratio (HR), 95% Confidence Interval...
Background: Screening echocardiography has emerged as a potentially powerful tool for early diagnosis of rheumatic heart disease (RHD). The utility screening hinges on the rate RHD progression and ability penicillin prophylaxis to improve outcome. We report longitudinal outcomes cohort children with latent identify risk factors unfavorable outcomes. Methods: This was prospective natural history study conducted under Ugandan registry. Children ≥1 year follow-up were included. All...
Portable echocardiography has emerged as a potential tool to detect rheumatic heart disease (RHD) early. Complex echocardiographic criteria used in recent epidemiological studies may be difficult translate into daily practice areas where the burden of RHD is greatest and skilled practitioners are lacking. The aim this study was evaluate simplified echo approach for screening among children low-income countries.Retrospective analysis data from cross-sectional echocardiography-based carried...
Background Rheumatic heart disease (RHD) is considered a major public health problem in developing countries, although scarce data are available to substantiate this. Here we quantify mortality from RHD Fiji during 2008–2012 people aged 5–69 years. Methods and Findings Using 1,773,999 records derived multiple sources of routine clinical administrative data, used probabilistic record-linkage define cohort 2,619 persons diagnosed with RHD, observed for all-cause over 11,538 person-years....