A5014727911- Streptococcal Infections and Treatments
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Coronary Artery Anomalies
- Congenital Anomalies and Fetal Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Issues in Pregnancy
- Tracheal and airway disorders
- Inflammasome and immune disorders
- Global Health Care Issues
- COVID-19 and healthcare impacts
- Neonatal and Maternal Infections
- Kawasaki Disease and Coronary Complications
- Rabies epidemiology and control
- Dermatological and COVID-19 studies
- Delphi Technique in Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Healthcare Policy and Management
- Actinomycetales infections and treatment
- Ultrasound in Clinical Applications
- Pancreatitis Pathology and Treatment
- Immunodeficiency and Autoimmune Disorders
- Pancreatic and Hepatic Oncology Research
Dartmouth–Hitchcock Medical Center
2020-2024
Children's Hospital at Dartmouth Hitchcock
2021-2024
Dartmouth Health
2023
Children's National
2019-2023
Zimmerman Associates (United States)
2020-2023
Dartmouth Psychiatric Research Center
2023
Uganda Management Institute
2023
Milken Institute
2022
George Washington University
2022
Institut de Virologie
2021
BackgroundPrevious congenital heart disease estimates came from few data sources, were geographically narrow, and did not evaluate throughout the life course. Completed as part of Global Burden Diseases, Injuries, Risk Factors Study 2017, this study aimed to provide comprehensive mortality, prevalence, disability by age for 195 countries territories 1990 2017.MethodsMortality generated aggregate non-fatal five subcategories (single ventricle single pathway anomalies; severe anomalies...
Congenital heart disease (CHD) is the leading cause of morbidity and mortality from birth defects worldwide. We report an overview trends in CHD 204 countries territories over past 30 years associations with age, period, cohort.Cause-specific estimates were derived Global Burden Disease 2019 study. utilised age-period-cohort model to estimate overall annual percentage changes (net drifts), 0 4 65-69 (local period cohort relative risks (period/cohort effects) between 1990 2019. This approach...
Rheumatic heart disease affects more than 40.5 million people worldwide and results in 306,000 deaths annually. Echocardiographic screening detects rheumatic at an early, latent stage. Whether secondary antibiotic prophylaxis is effective preventing progression of unknown.
Background Recent evaluation of rheumatic heart disease (RHD) mortality demonstrates disproportionate burden within the United States. However, there are few contemporary data on US children living with acute fever (ARF) and RHD. Methods Results Twenty‐two pediatric institutions participated in a 10‐year review (2008–2018) electronic medical records echocardiographic databases 4 to 17 years diagnosed ARF/RHD determine demographics, diagnosis, management. Geocoding was used census tract‐based...
To evaluate the long-term clinical outcomes of children with rheumatic heart disease (RHD) in Uganda, and determine characteristics that predict adverse outcomes.
Congenital heart defects (CHD) are the most common birth and previous estimates report disease affects 1% of births annually in United States. To date, CHD prevalence inconsistent due to varied definitions, data reliant on registries, geographically limited. These sources may not be representative total population. It is therefore important derive high-quality, population-based help care for this vulnerable
Background Despite the high burden of rheumatic heart disease in sub-Saharan Africa, diagnosis with acute fever (ARF) is exceedingly rare. Here, we report results first prospective epidemiologic survey to diagnose and characterize ARF at community level Africa. Methods Results A cross-sectional study was conducted Lira, Uganda, inform design a broader survey. Key messages were distributed community, children aged 3 17 years included if they had either (1) joint pain, (2) suspicion carditis,...
Aim Non‐expert training in rheumatic heart disease (RHD) detection is a valuable strategy resource‐limited settings. Here we present an innovative handheld ultrasound application featuring views of correct probe position, imaging protocol and echocardiographic loops RHD pathology versus normal, accessible during real‐time scanning. Methods This prospective study was implemented into pre‐existing school health screening programme at elementary Koror, Palau. Six learners with no prior...
Background: Health-related quality of life (HRQOL) is a critical issue for patients undergoing surgery congenital heart disease (CHD) but has never been assessed in low-income country. We conducted cross-sectional mixed methods study with age-matched healthy siblings serving as controls at the Uganda Heart Institute. Methods: One-hundred fifteen CHD pediatric and young adult sibling control participants were recruited. was using Pediatric Quality Life Inventory Version 4.0 ages 5–17 36-Item...
Objective Despite substantial variation of streptococcal antibody titres among global populations, there is no data on normal values in sub-Saharan Africa. The objective this study was to establish for antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies Uganda. Design This an observational cross-sectional study. Setting conducted at Mulago National Referral Hospital, which located the capital city, Kampala, includes Uganda Heart Institute. Patients Participants (aged 0–50...
Timely diagnosis of group A streptococcal (GAS) sore throat coupled with appropriate antibiotic treatment is necessary to prevent serious post-streptococcal complications, including rheumatic fever (RF) and heart disease (RHD). Traditional medicine (TM) a known common adjunct formal medical care in sub-Saharan Africa. better understanding health-seeking behavior for both within outside the system critical improving primary prevention efforts RF RHD. prospective mixed-methods study on use TM...
Background: Screening echocardiograms can detect early-stage rheumatic heart disease (RHD), offering a chance to limit progression. Implementation of screening programs is challenging and requires further research. This the first large-scale study assessing risk RHD among previous screen-negative children. Methods: retrospective cohort study, conducted in Gulu, Uganda, performed school-based echo on children ages 5–18 years. Surveys were used determine which underwent initial 3–5 years...
Introduction: Rheumatic heart disease affects 40.5 million people globally and causes 306,000 annual deaths. Echocardiographic screening detects rheumatic at an early, latent stage. However, it is unknown if secondary antibiotic prophylaxis effective preventing progression of disease. Methods: We conducted a randomized controlled trial among Ugandan children (5-17 years) with to receive either 4-weekly injections benzathine benzylpenicillin G or no prophylaxis. All underwent echocardiography...
Introduction: Children with congenital heart disease (CHD) typically require care from a multi-disciplinary team of providers and treatment at specialized centers. Although access to specialty is known influence patient outcomes, little regarding geographic for children disease. This study calculated travel time centers the relationship mortality residing in Colorado. Methods: We analyzed all payer claims data (APCD) Colorado (CO) 2012-2019. Travel times were using network analysis road...