A5058425837- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Outbreaks Research
- Emergency and Acute Care Studies
- Otolaryngology and Infectious Diseases
- Inflammasome and immune disorders
- Rabies epidemiology and control
- Clinical Reasoning and Diagnostic Skills
- Dermatological and COVID-19 studies
- Thermal Regulation in Medicine
- Immunodeficiency and Autoimmune Disorders
- Cardiac Structural Anomalies and Repair
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- Telemedicine and Telehealth Implementation
- Respiratory viral infections research
- Nursing Diagnosis and Documentation
- Drug-Induced Hepatotoxicity and Protection
- Bacterial Identification and Susceptibility Testing
- Ultrasound in Clinical Applications
- Cardiovascular Issues in Pregnancy
- Energy and Environment Impacts
- Mobile Health and mHealth Applications
- Acute Myocardial Infarction Research
Uganda Management Institute
2018-2025
Mulago Hospital
2020-2023
Lira Hospital
2023
Associates Research
2021-2022
University of Washington
2020
Background: Regular outpatient visits to healthcare facilities for benzathine penicillin injections are the primary means of secondary prevention patients with Rheumatic Heart Disease (RHD). It has been widely demonstrated that individual access disrupted by COVID-19 outbreak, but its impact on RHD not studied. Methods: Using a stratified random sampling strategy, we conducted baseline and follow-up survey in Western Uganda between November 2019 February 2020, 2020 2021, obtained 486...
<title>Abstract</title> Acute Rheumatic Fever (ARF) is a systemic inflammatory condition triggered by Group A Streptococcus infection, with timely diagnosis critical to prevent Heart Disease. ARF pathogenesis poorly understood and based on clinical criteria. Here, we compared cases well-defined controls from two Uganda cohorts. We identified 5-protein signature that discriminates patients clinically-similar conditions (receiver operating characteristic-area under the curve (ROC-AUC)=1.0,...
Background In 2018, the World Health Assembly mandated Member States to take action on rheumatic heart disease (RHD), which persists in countries with weak health systems. We conducted an assessment of current state RHD-related healthcare Uganda. Methodology/Principal findings This was a mixed-methods, deductive simultaneous design study four districts Using census sampling, we surveyed facilities each district using RHD survey instrument that modeled after WHO SARA tool. interviewed workers...
Background: Rheumatic heart disease (RHD) has declined dramatically in wealthier countries the past three decades, but it remains endemic many lower-resourced regions and can have significant costs to households. The objective of this study was quantify economic burden RHD among Ugandans affected by RHD. Methods: This a cross-sectional cost-of-illness that randomly sampled 87 participants their households from Uganda National registry between December 2018 February 2020. Using standardized...
<strong>Introduction:</strong> Rheumatic heart disease (RHD) remains a significant public health problem in countries with limited resources. People living RHD face numerous social challenges and have difficulty navigating ill-equipped systems. This study sought to understand the impact of on PLWRHD their households families Uganda. <strong>Methods:</strong> In this qualitative study, we conducted in-depth interviews 36 people sampled purposively from Uganda's national research registry,...
Background Despite the high burden of rheumatic heart disease in sub-Saharan Africa, diagnosis with acute fever (ARF) is exceedingly rare. Here, we report results first prospective epidemiologic survey to diagnose and characterize ARF at community level Africa. Methods Results A cross-sectional study was conducted Lira, Uganda, inform design a broader survey. Key messages were distributed community, children aged 3 17 years included if they had either (1) joint pain, (2) suspicion carditis,...
<strong>Background:</strong> Untreated streptococcal pharyngitis is a precursor to rheumatic heart disease (RHD) and remains significant public health issue in many countries. Understanding local determinants of treatment-seeking behaviors can help tailor RHD prevention programs. <strong>Objective:</strong> We sought elicit perceptions related healthcare use range communities Uganda. <strong>Methods:</strong> conducted six focus group discussions (FGD) three districts that were...
Objective Despite substantial variation of streptococcal antibody titres among global populations, there is no data on normal values in sub-Saharan Africa. The objective this study was to establish for antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies Uganda. Design This an observational cross-sectional study. Setting conducted at Mulago National Referral Hospital, which located the capital city, Kampala, includes Uganda Heart Institute. Patients Participants (aged 0–50...
In Uganda, limited healthcare access has created a significant burden for patients living with heart failure. With the increasing use of mobile phones, digital health tools could offer an accessible platform individualized care support. 2016, our multi-national team adapted phone-based program failure self-care to Ugandan context and found that using system showed improvements in their symptoms quality life. approximately 84% Ugandans residing rural communities, Medly Uganda can provide...
Abstract Objective Most rheumatic heart disease (RHD) registries are static and centralized, collecting epidemiological clinical data without providing tools to improve care. We developed a dynamic cloud-based RHD case management application with the goal of improving care for patients in Uganda. Methods The Active Community Case Management Tool (ACT) was designed community-based chronic disease, as first test case. Global local partner consultation informed selection critical fields...
Objective To determine the ability to accurately diagnose acute rheumatic fever (ARF) given resources available at three levels of Ugandan healthcare system. Methods Using data obtained from a large epidemiological database on ARF conducted in districts Uganda, we selected variables that might positively or negatively predict based diagnostic capacity levels/tiers Variables were put into statistical models built sequentially. Multiple logistic regression was used estimate ORs and 95% CI...
Timely diagnosis of group A streptococcal (GAS) sore throat coupled with appropriate antibiotic treatment is necessary to prevent serious post-streptococcal complications, including rheumatic fever (RF) and heart disease (RHD). Traditional medicine (TM) a known common adjunct formal medical care in sub-Saharan Africa. better understanding health-seeking behavior for both within outside the system critical improving primary prevention efforts RF RHD. prospective mixed-methods study on use TM...
Introduction Rheumatic heart disease (RHD) affects over 39 million people worldwide, the majority in low-income and middle-income countries. Secondary antibiotic prophylaxis (SAP), given every 3–4 weeks can improve outcomes, provided more than 80% of doses are received. Poor adherence is strongly correlated with distance travelled to receive prophylaxis. Decentralising RHD care has potential bridge these gaps at least maintain or potentially increase uptake. A package implementation...
Abstract Background Rheumatic heart disease (RHD) is most prevalent in socially disadvantaged settings, placing a severe burden on patients and their households. The study aims to investigate the disparity of healthcare costs, including financial time among RHD Uganda. Methods We enrolled 54 households from Uganda National Registry between June 2019 February 2021. were interviewed baseline 12-month follow-up surveys. A random-effect model was applied examine costs. Our primary outcomes are...
Abstract Background Central to rheumatic fever (RF) diagnosis is evidence of streptococcal exposure, specifically antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies. It unknown if these antibody titers should be adjusted the background exposure rates GAS or published standards used. Here, we establish normal values ASO ADB in Uganda examine RF case detection using vs. population-specific thresholds. Methods Participants (age 0-50 years) were recruited. was measured...
Background: Central to rheumatic fever (RF) diagnosis is evidence of streptococcal exposure, specifically antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies. It unknown if these antibody titers should be adjusted the background exposure rates GAS or published standards used. Here, we establish normal values ASO ADB in Uganda examine RF case detection using vs. population-specific thresholds. Methods: Participants (age 0-50 years) were recruited. was measured in-country by...
Introduction: Although Group A Streptococcal (GAS) pharyngitis (sore throat) can be treated, its complications -- acute rheumatic fever (ARF) and heart disease (RHD) remain significant public health problems in low- middle -income countries. Examining community perceptions seeking behavior for sore throat these settings could translate into effective ARF/RHD prevention strategies. Objective: To develop a local explanatory model of that used designing preventive interventions Methods: This...