A5040157120- Global Health Care Issues
- Global Maternal and Child Health
- Pharmaceutical Practices and Patient Outcomes
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Heart Failure Treatment and Management
- Global Public Health Policies and Epidemiology
- Blood Pressure and Hypertension Studies
- Antibiotic Use and Resistance
- Health disparities and outcomes
- Healthcare Systems and Reforms
- Pharmaceutical studies and practices
- Climate Change and Health Impacts
- Medication Adherence and Compliance
- Acute Ischemic Stroke Management
- HIV Research and Treatment
- Research on Leishmaniasis Studies
- HIV/AIDS drug development and treatment
- Nausea and vomiting management
- Drug Transport and Resistance Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Anesthesia and Sedative Agents
- Sodium Intake and Health
- Patient Satisfaction in Healthcare
- Pharmacovigilance and Adverse Drug Reactions
Mekelle University
2018-2024
Institute for Health Metrics and Evaluation
2018-2019
University of Washington
2018-2019
Auckland University of Technology
2018-2019
University of Groningen
2018
Jimma University
2017
Neurological disorders are now the leading source of disability globally, and ageing is increasing burden neurodegenerative disorders, including Parkinson's disease. We aimed to determine global disease between 1990 2016 identify trends enable appropriate public health, medical, scientific responses.Through a systematic analysis epidemiological studies, we estimated global, regional, country-specific prevalence years life lived with for from 2016. proportion mild, moderate, severe on basis...
<h2>Summary</h2><h3>Background</h3> Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from GBD 2016 study provide new estimates for prevalence years life lived with disability (YLDs) migraine tension-type present methods results in an accessible way clinicians researchers disorders. <h3>Methods</h3> Data were derived population-based cross-sectional surveys on headache....
Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality residual disability). Data on are needed for health-care planning resource allocation. The aim this study was quantify due by age, sex, year, location using data from Global Burden Diseases, Injuries, Risk Factors Study.We assessed in 195 countries territories 1990 2016. measured as deaths, prevalence, disability-adjusted life-years (DALYs; a summary measure defined...
BackgroundPrevious congenital heart disease estimates came from few data sources, were geographically narrow, and did not evaluate throughout the life course. Completed as part of Global Burden Diseases, Injuries, Risk Factors Study 2017, this study aimed to provide comprehensive mortality, prevalence, disability by age for 195 countries territories 1990 2017.MethodsMortality generated aggregate non-fatal five subcategories (single ventricle single pathway anomalies; severe anomalies...
Brain and CNS cancers (collectively referred to as cancers) are a source of mortality morbidity for which diagnosis treatment require extensive resource allocation sophisticated diagnostic therapeutic technology. Previous epidemiological studies limited specific geographical regions or time periods, making them difficult compare on global scale. In this analysis, we aimed provide comparable comprehensive estimation the burden brain cancer between 1990 2016.We report means 95% uncertainty...
Introduction Healthcare-associated infections (HAIs) have become a serious public health problem. Despite the fact that implementing evidence-based infection control strategies could prevent HAIs and save billions of dollars, Ethiopia lacks national surveillance studies on rate, economic, clinical burden HAIs. Objective To assess economic in hospitalized patients at Ayder comprehensive specialized hospital. Materials methods A prospective cohort study design was conducted with without review...
Abstract Background Geriatric patients are at high risk of Drug Related Problems (DRPs) due to multi- morbidity associated polypharmacy, age related physiologic changes, pharmacokinetic and pharmacodynamics alterations. These often excluded from premarketing trials that can further increase the occurrence DRPs. This study aimed identify drug problems determinants in geriatric admitted medical surgical wards, evaluate impact clinical pharmacist interventions for treatment optimization....
Epilepsy is a major public health problem worldwide. Despite multiple drug therapies, people with epilepsy continue to have frequent seizures. There dearth of data on treatment outcome and associated factors in our setting. Therefore, the aim this was assess among epileptic patients follow up at neurologic clinic Ayder comprehensive specialized hospital, Ethiopia. A cross-sectional study conducted randomly selected patients. Data were collected through patient interview review medical...
Background . Medication adherence and belief are crucial to achieving the desired goal of therapy in epileptic patients. However, there is a lack study regarding medication our setting. Therefore, purpose this was investigate associated factors among ambulatory patients with epilepsy. Method A cross-sectional conducted on randomly selected at neurologic clinic Ayder Comprehensive Specialized Hospital, Ethiopia. were assessed using self-reported questionnaires which developed based review...
Abstract Background Optimal utilization of cardiovascular drugs is crucial in reducing morbidity and mortality associated with diseases. However, the effectiveness these can be compromised by drug therapy problems. Hospitalized patients diseases, particularly those multiple comorbidities, polypharmacy, advanced age, are more susceptible to experiencing little known about problems their contributing factors among disease our setting. Therefore, study aimed investigate Method A prospective...
Abstract Despite the indispensable role of self-care behavior in managing heart failure, practice remains poor, especially developing countries. There is a scarcity research focusing on poor and its determinants within our specific context. Therefore, objective this study was to investigate prevalence predictors among ambulatory failure patients. A facility-based cross-sectional conducted at tertiary care hospital Ethiopia, involving patients with failure. We utilized European Heart Failure...
Despite the benefits of evidence-based self-care behaviors in management hypertension, hypertensive patients have low rate adherence to recommended behaviors. Studies related among are limited Ethiopia.To assess and associated factors patients.A cross-sectional study was conducted at cardiac clinic Ayder comprehensive specialized hospital ambulatory patients. Self-care were assessed using an adopted Hypertension Self-Care Activity Level Effects (H-SCALE). Data collected through patient...
Objective This study aimed to assess the knowledge, attitude and practice of adverse drug reactions (ADRs) reporting identify factors associated with ADRs among healthcare professionals (HCPs) working in Tigray region, Ethiopia. Materials methods A cross-sectional was conducted between January March 2019 a tertiary care hospital self-administered, pretested questionnaire administered HCPs. Data were summarised using descriptive statistics. Logistic regression analysis used poor practices....
Background The practice of self-medication during pregnancy is a global challenge that necessitates high attention as it poses potential threat to the pregnant mother and fetus. However, little known regarding its contributors among women in our setting. Objective main aim this study was investigate contributing factors Methodology A cross sectional conducted at antenatal care follow-up Ayder comprehensive specialized hospital, Tigray, Ethiopia. Written informed consent obtained from each...
Chemotherapy induced nausea and vomiting (CINV) remains the most distressing event in patients receiving highly emetogenic chemotherapy (HEC) or moderately (MEC). Therefore, this meta-analysis was conducted to evaluate efficacy of olanzapine containing regimen preventing acute, delayed overall phases CINV. PubMed, EBSCO, Cochrane central register controlled trials electronic databases were searched identify RCTs that compared effects with non-olanzapine Randomized clinical (RCTs) included....
Abstract Although evidence based guidelines recommend optimal use of beta blockers in all patients with chronic heart failure unless contraindicated, they are often underutilized and/or prescribed below the recommended dosage majority failure. To our knowledge, however, beta-blockers is not investigated Ethiopia. Therefore, aim study was to investigate utilization and optimization management A prospective observational conducted among ambulatory We included adult a diagnosis baseline left...
HIV/AIDS remained among the common public health problems in developing country. Despite extensive delivery of ART and improved coverage service access, still, man-made like war have negatively influenced utilization antiretroviral treatment services. The Tigray Region northern Ethiopia broke out November 2020 thereby has brought about an extreme damage on most infrastructure Tigray, including institutions. purpose this study is, therefore, to assess report trend HIV provision across...
Early initiation of highly active antiretroviral therapy (HAART) decreases human immunodeficiency virus- (HIV-) related complications, restores patients' immunity, viral load, and substantially improves quality life. However, treatment failure considerably impedes the merits HAART.This study is aimed at determining prevalence immunologic clinical failure.A cross-sectional design using definition was used to conduct study. Sociodemographic characteristics features patients were retrieved from...
Abstract Background: Geriatric patients are at high risk of Drug Related Problems (DRPs) due to multi- morbidity associated polypharmacy, age related physiologic changes, pharmacokinetic and pharmacodynamics alterations. These often excluded from premarketing trials that can further increase the occurrence DRPs. This study was aimed identify DRPs determinants in geriatric admitted medical surgical wards, evaluate impact clinical pharmacist interventions for treatment optimization. Methods: A...
Inappropriate use of medicine is a global challenge with greater impact on developing countries. Assessment drug pattern used to identify gaps in utilisation implement strategies for promoting rational use. This study aimed assess using the WHO indicators selected general hospitals Tigray region, Ethiopia.A cross-sectional was conducted two public located Tigray.Prescriptions recorded from 1 January 2017 June 2019 were randomly selected, and participants who visited March 30 August hospital...
Background. Visceral leishmaniasis (VL), one of the most neglected tropical diseases, is placing a huge burden on Ethiopia. Despite introduction antileishmanial drugs, treatment outcomes across regions are variable due to drug resistance and other factors. Thus, understanding VL its contributing factors helps decisions treatment. However, magnitude risk poor outcome not well studied in our setting. Therefore, study was designed assess associated patients with VL. Materials Methods. A...
Abstract Epilepsy is a chronic neurological disease with variable therapeutic response. To design effective treatment strategies for epilepsy, it important to understand responses and predictive factors. However, limited data are available in Africa, including Ethiopia. The aim of this study was therefore assess response identify prognostic predictors among patients epilepsy at Jimma university medical center, We conducted retrospective cohort 404 newly diagnosed adult receiving...
Ethiopia has one of the highest HIV burdens in sub-Saharan Africa. Despite fact that second-line antiretroviral therapy (ART) been available for more than ten years, studies on its effectiveness are scarce.To assess treatment outcomes and predictors unfavorable patients receiving ART at Ayder Comprehensive Specialized Hospital Mekelle Hospital.An institution-based retrospective cohort study was conducted two hospitals Tigray Region, Ethiopia. We evaluated 192 aged ≥15 years who were switched...
Optimal use of angiotensin-converting enzyme inhibitors (ACEIs) is crucial to improve the treatment outcome in heart failure patients. However, little known about optimal ACEIs among patients our setting. Therefore, study aimed investigate utilization and dosing associated factors patients.A cross-sectional was conducted on randomly selected with between February 2016 June at ambulatory care clinic Jimma University Medical Center, Ethiopia. Data were collected through patient interview...