A5002047973- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Curcumin's Biomedical Applications
- Global Health Care Issues
- Sphingolipid Metabolism and Signaling
- Effects and risks of endocrine disrupting chemicals
- Multiple Sclerosis Research Studies
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Long-Term Effects of COVID-19
- Reproductive System and Pregnancy
- Health disparities and outcomes
- Global Maternal and Child Health
- Advanced Nanomaterials in Catalysis
- Global Public Health Policies and Epidemiology
- Mesenchymal stem cell research
- Pregnancy and Medication Impact
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Climate Change and Health Impacts
- Medicinal Plants and Neuroprotection
Babol University of Medical Sciences
2016-2025
Institute for Health Metrics and Evaluation
2018-2019
Auckland University of Technology
2019
University of Washington
2018-2019
Cellular Research (United States)
2017
Tarbiat Modares University
2012-2017
BackgroundThe number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding disease burden. We aimed present first detailed analysis global prevalence, mortality, overall burden as captured by Global Burden Diseases, Injuries, Risk Factors (GBD) Study 2016, highlight most important messages for clinicians neurologists.MethodsGBD 2016...
Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality residual disability). Data on are needed for health-care planning resource allocation. The aim this study was quantify due by age, sex, year, location using data from Global Burden Diseases, Injuries, Risk Factors Study.We assessed in 195 countries territories 1990 2016. measured as deaths, prevalence, disability-adjusted life-years (DALYs; a summary measure defined...
Background The conversion of astrocytes to neuroblasts holds great promise for treatment neurodegenerative and traumatic brain diseases. Methodology Principal Findings Here we have shown that adult human could be reprogrammed by miR-302/367, both in vivo vitro. However, the reprogramming mouse required valproic acid (VPA), a histone deacetylase inhibitor. Following induction toward neurons expression pluripotency markers were not detected, which suggested direct cell conversion. We did...
Natural herbal compounds have been widely introduced as an alternative therapeutic approach in cancer therapy. Despite potent anticancer activity of curcumin, its clinical application has limited because low water solubility and resulting poor bioavailability. In this study, we designed a novel ultrasonic-assisted method for the synthesis curcumin-loaded chitosan-alginate-sodium tripolyphosphate nanoparticles (CS-ALG-STPP NPs). Furthermore, antitumor effect NPs was evaluated vitro. Field...
Enhancement of repair potential for degenerative brain diseases has been a research priority during recent years. Considering advancements in the field direct transdifferentiation, conversion astrocytes as prominent component glial scars to progenitor cells that contribute mechanisms seems interesting. Recently, we have reported miR-302/367-mediated vivo into neuroblasts and neurons. In current study, used miR-302/367 valproate (VPA) show possibility oligodendrocyte myelinating cuprizone...
Objectives: Recent evidences have shown the beneficial effects of natural products for treating Alzheimer's disease (AD). Arbutin is derived from Pyrus biossieriana and exerts a wide range pharmacological activities including anti-inflammatory anti-oxidant effects. The present study was designed to examine protective arbutin on streptozotocin (STZ)-induced neurotoxicity in rats.Materials methods: spatial memory impairment induced by intracerebroventricular (i.c.v) microinjection STZ (3...
Background: Despite the numerous pharmacological activities of quercetin, its biomedical application has been hampered, because poor water solubility and low oral bioavailability.In present study, we fabricated a novel form quercetin-conjugated Fe 3 O 4 -β-cyclodextrin (βCD) nanoparticles (NPs), effect these prepared NPs was evaluated in chronic model epilepsy.Methods: Quercetin-loaded were using an iron oxide core coated with βCD pluronic F68 polymer.The epilepsy developed by...
Background: Naringin and MCC950 as an inflammasome inhibitor have exhibited numerous pharmacological activities, including antioxidant anti-inflammatory effects. The present study has examined the combined impacts of naringin on levels oxidative stress, demyelination, inflammation in cuprizone (CPZ)-induced demyelination model. Methods: In order to induce CPZ (0.2% w/w) was added normal diet mice for 42 days. Subsequently, male C57BL/6 received (oral administration), (intraperitoneal...
ABSTRACT Metal–organic frameworks (MOFs) have been gaining significant attention due to their potential application in medicine. Here, we investigated the effect of zeolite imidazole framework‐8 (ZIF‐8) on neuro‐behavioral parameters, histopathology, inflammation, and oxidative stress levels rats' brain samples. Forty‐eight male Wistar rats were injected by four injections saline or ZIF‐8 at different doses 5, 10, 20 mg/kg via caudal vein. Y‐Maze, Morris‐Water Maze (MWM), three chamber tests...