Type 2 diabetes mellitus (T2DM), the most prevalent metabolic disorder worldwide, has genetic, epigenetic, and environmental contributors. Among them, circulating microRNAs (miRNAs/miRs) have attracted considerable attention. This study aimed to investigate regulatory role of miR-103 in T2DM development.

ABSTRACT Background Cancer is a major cause of mortality. Timely information about cancer mortality trends essential for prioritizing health programs. Aims This study aims to use Joint point regression model predict the rates top 10 common cancers in Babol City. Methods cross‐sectional considered all registered cancer‐related deaths from 2013 2021 University Medical Sciences' death registration and classification system. Crude age‐standardized were calculated predicted next 5 years, overall...

Background.Repairing aged composite resin is a challenging process.Many surface treatment options have been proposed to this end.This study evaluated the effect of different treatments on shear bond strength (SBS) nanofilled repairs. Methods.Seventy-five cylindrical specimens Filtek Z350XT were fabricated and stored in 37°C distilled water for 24 hours.After thermocycling, divided into 5 groups according following treatments: no (group 1); air abrasion with 50-µm aluminum oxide particles 2);...

Platelet-rich plasma (PRP) and hyaluronic acid have been shown to be useful in the treatment of knee osteoarthritis. However, investigations comparing efficacy these two drugs together are insufficient.To compare outcomes PRP vs injections three groups patients with bilateral osteoarthritis.This randomized controlled trial study involved 95 patients. Thirty-one subjects received a single injection (group PRP-1), 33 at an interval 3 wk PRP-2) 31 1-wk intervals acid). The were investigated...

Abstract Objective Menopausal symptoms can significantly impact women's quality of life. Herbal interventions like Matricaria chamomilla (chamomile) have been suggested as potential remedies. However, their efficacy and safety remain underexplored. Methods This triple-blind clinical trial enrolled 80 postmenopausal women meeting specific criteria. Inclusion criteria included participants in early or late perimenopause, defined by a symptom score >15, FSH levels >40, 2 years since...

A majority of small size kidney in children were diagnosed after a urinary tract infection (UTI) and with high-grade vesicoureteral reflux (VUR). This study was conducted who accidentally investigated for VUR UTI. longitudinal retrospective diagnosis discovered by ultrasonography referred to Children's Hospital Babol, Iran, between 2012-2022. They DMSA (dimercapto succinic acid) renoscintigraphy scans. Vesicoureteral voiding C\cystourethrography (VCUG) or radionuclide cystography (RNC). All...

Abstract Introduction: Internet-based psychotherapies are considered promising approaches to enhancing ease of use and comfort for pregnant women. The present study aimed compare the effectiveness stress inoculation therapy (ISIT) emotion-focused cognitive behavioral (IECBT) in decreasing anxiety, depression, Materials Methods: A total 60 women were included quasi-experimental multicenter with diagnosis depression or anxiety disorder according Diagnostic Statistical Manual Mental Disorders,...

Objective . Little research is available on the predictive factors of self-efficacy in college students. The aim present study to examine role alexithymia, anxiety, and depression predicting academic Design In a cross-sectional study, total 133 students at Babol University Medical Sciences (Medicine, Dentistry, Paramedicine) participated between 2014 2015. All participants completed Toronto Alexithymia Scale (TAS-20), College Academic Self-Efficacy (CASES), 14 items anxiety derived from 28...

Diabetes mellitus is one of the systemic disease which show important oral manifestation and influence health. This study describes how diabetes affects health health-related quality life. The aim this was to evaluate life diabetic patients compare discriminative capability Persian versions two GOHAI OHIP-14 questionnaires in these patients.A total 350 with Type II mellitus, referring Clinic, were selected data collected by completed clinical examinations. Oral parameters (CAL,BI,GI,PLI,DMFT...

Several mechanisms have been proposed to explain the adverse effect of obesity on quality life among women with breast cancer, including alteration in some inflammatory markers. The aim this study was determine status serum levels leptin, IL-6 and CRP obese, overweight normal weight cancer survivors order relationship between markers' obesity.This cross-sectional done 75 30 15 patients. Serum IL-6, CRP, total protein, albumin lipid profile as well anthropometric parameters were measured...

Objectives: Recent evidences have shown the beneficial effects of natural products for treating Alzheimer's disease (AD). Arbutin is derived from Pyrus biossieriana and exerts a wide range pharmacological activities including anti-inflammatory anti-oxidant effects. The present study was designed to examine protective arbutin on streptozotocin (STZ)-induced neurotoxicity in rats.Materials methods: spatial memory impairment induced by intracerebroventricular (i.c.v) microinjection STZ (3...

Menstrual pain is a periodic which happens during the days of menses. The menstrual disturbances as health problem among young girls affect not only reproductive, but also psychical and quality life. This study was done with goal comparing effect Ginger Novafen on pain. crossover clinical trial in Iran 168 single girl students 18–26 years old Babol University Medical Sciences primary participants were randomly allocated to two groups receiving drugs Ginger. At beginning pain, 200 mg capsule...

Lack of sufficient knowledge about the unknowns pregnancy increases stress and requires more medical interventions. This study was conducted to assess effects prenatal education on mothers' labor. clinical trial 195 women (132 in control group 63 experimental group) who had attended healthcare centers city Amol after their 16th gestational week. The participated educational classes learn how experience a safe childbirth for 6-8 sessions 1.5 hours almost every three weeks. received only...

Dental ceramics are appreciated as highly esthetic restorative materials that can simulate the appearance of natural dentition better than other materials. The aim this study was to evaluate effect hydrofluoric acid concentration and etching time on micro-shear bond strength (μSBS) IPS e.max CAD Vita Mark II a dual cured resin cement (Panavia F2.0).This an experimental in vitro study, performed dental material research center Babol University Medical Sciences 2016. Two concentrations (5%...

Breast cancer (BC) is known as the most prevalent type of among women. Trastuzumab, an anticancer drug, has been used broadly in human epidermal growth factor receptor 2 (HER-2) positive (+) BC patients. Moreover, accumulating evidence demonstrated that microRNAs involved pathogenesis BC. Hence, we aimed to investigate effect trastuzumab on expression levels microRNA-26a HER-2 patients.This study was conducted + and Negative (-) Serum detected by real-time PCR. Then, assessed correlations...

Gum chewing after cesarean section may stimulate bowel motility and decrease duration of postoperative ileus.The current study assessed the effect sugar-free gum on return function, where had been performed in nulliparous women.In a randomized clinical trial, 60 patients, scheduled for were randomly divided to 2 groups gum-chewing group (n = 30) control postoperatively. The patients postoperatively chewed sugar free 3 times daily each time 1 hour until discharge. patients' demographic...

Abstract Objective: Polycystic ovary syndrome (PCOS) is linked with metabolic syndrome, which includes obesity, insulin resistance, dyslipidemia, and endocrine function in patients PCOS. The aim of this study was to determine the prevalence adolescent PCOS characteristics associated adolescents Babol, Iran. Materials methods: A cross-sectional conducted on 1549 girl high school students aged 16–20 years who were living After overnight fasting, blood samples collected hormones lipid levels...

There is lack of information about the effect general distress and pregnancy-specific in mid- late-pregnancy separately on neonatal outcome.The aim this study was to assess effects mid-maternal late-maternal birth outcomes with a causal model relationships among distress.In longitudinal descriptive study, 100 low-risk pregnant women participated. Participants completed three questionnaires at mid-pregnancy (13-26 wk) late pregnancy (27-40 wk). Pregnancy-general assessed by Perceived Stress...

Abstract Objective Rapid, reliable, and affordable detection of Brucella species via the molecular methods remains a challenge. In recent years, loop-mediated isothermal amplification (LAMP) is functional nucleic acid technique offering substitute to polymerase chain reaction (PCR). So, we compared LAMP assay with conventional PCR for identification common in Iran. this study, was comprehensively evaluated against method. A group specific primers were used amplify highly fragment from...