A5010626397- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Drug-Induced Adverse Reactions
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- HIV/AIDS Research and Interventions
- Healthcare cost, quality, practices
- Pharmacological Effects and Toxicity Studies
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- Pharmaceutical studies and practices
- Dermatological and COVID-19 studies
- Viral Infections and Outbreaks Research
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Impact on Reproduction
- Dialysis and Renal Disease Management
City Of Hope National Medical Center
2020-2024
City of Hope
2020-2024
University of California, Los Angeles
2019
University of Southern California
2017-2019
UCLA Medical Center
2019
LAC+USC Medical Center
2017
COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-expressing SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety immunogenicity in healthy adults.This combined open-label randomised, phase 1 trial done at the City of Hope Comprehensive Cancer Center (Duarte, CA, USA). We included participants aged 18-54 years with negative antibody PCR test, normal haematology chemistry panels, electrocardiogram troponin concentration, pregnancy test if female, body-mass...
Abstract Background Pneumonia is a common cause of morbidity and mortality, yet causative pathogen identified in minority cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield immunocompromised patients with pneumonia. Methods In this prospective, multicenter, observational study adults undergoing bronchoscopy to establish pneumonia etiology, plasma was compared standardized usual care testing. etiology adjudicated by blinded independent committee. The primary...
We report here a fatal case of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in renal transplant patient without travel history the prior year, from whom 2 genetically different CRKP (sequence type 14 [ST14] and ST2497) strains carrying same plasmids antimicrobial resistance genes, including blaNDM-1, blaOXA-232, blaCTX-M-15, armA, tet(D), were isolated blood abdominal cavity. The isolates susceptible to colistin, tigecycline, eravacycline, cefiderocol, which was used treat...
Frailty is a widely used measure in older patients as predictor of poor outcomes after hospitalization and surgery. There growing body data kidney transplantation suggesting frailty can predict adverse outcomes. interest using chart review measures multimorbidity, they may be equally predictive physical measurement. This approach holds promise for patient evaluation, identifying candidates prehabilitation, targeting resources towards those anticipated to have an increased rate clinical...
Abstract Background Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying in plasma. However, data are needed to define clinical scenarios where this tool offers highest benefit. Methods We conducted a prospective multicenter observational study that evaluated impact plasma mcfDNA compared with usual care testing among adults hematologic malignancies. This is secondary analysis an expanded cohort utility across...
Continuing antifungal prophylaxis (AFPx) to prevent invasive mold infections (IMIs) in recipients of allogeneic hematopoietic cell transplantation (alloHCT) after primary hospital discharge from alloHCT admission varies among transplant centers despite recommendations continue through day +75. Characteristics driving AFPx prescribing at and outcomes are unknown. In this retrospective analysis, we reviewed patients continuing vs no discharge. We included with a stay ≥7 days ≤40 days. excluded...
Abstract Background Pneumonia is the most common infectious cause of morbidity and excess mortality complicating hematopoietic cell transplantation (HCT) treatment hematologic malignancy. Standard bronchoscopic noninvasive microbiologic testing identify causative pathogens in less than half cases. The Karius Test, a plasma next-generation sequencing assay microbial cell-free DNA, may improve diagnostic yield these patients. Methods Patients with active malignancy or recent HCT undergoing...
Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) reduces bone mineral density in HIV-uninfected men who have sex (MSM). We hypothesized that PrEP TDF-FTC would increase turnover markers (BTMs) at week 24 and vitamin D supplementation from weeks to 48 blunt this increase. Participants were a cohort of 398 MSM transgender women received daily for PrEP. At 24, prospective intervention group initiated D3 4,000 IU daily. Concurrent controls selected the...
The endemic mycoses are an important cause of morbidity and mortality in transplant recipients. These fungal infections notable for a dimorphic life cycle, specific geographic distribution, typical infection via environmental exposure. Their nonspecific presentation, often mimicking other infections, can make diagnosis challenging. An is Coccidioides spp., which to the southwest United States severe pneumonia or meningitis, as well bone joint infection. Coccidioidomycosis unique that it more...
Abstract Background Clostridium difficile infection (CDI) is one of the most common healthcare-associated infections. Timely diagnosis key to reducing associated morbidity and costs. Healthcare-onset (HO) CDI defined as diagnosed 72 hours after hospitalization. Centers for Medicare Medicaid Services has established benchmarks HO-CDI hospitals, which are based on several factors including type hospital case mix index. There a financial penalty if we above benchmark. In 2016, 20% our...
Invasive aspergillosis (IA) is a serious fungal infection that primarily affects patients with prolonged and profound neutropenia, compromised cell-mediated immunity. Aspergillosis of the oesophagus gastrointestinal tract uncommon but seen in advanced cases disseminated IA. However, it difficult to diagnose antemortem due poor specificity symptoms absence characteristic imaging findings. Therefore, reported have been associated high morbidity mortality, frequently diagnosed postmortem. Here...
Abstract Background HSV reactivation (HSVr) is frequent in HM and SOM patients while oropharyngeal/ mucocutaneous infections (OP-MCI) especially pneumonitis (HSVP) are uncommon. BALF-HSV-PCR can identify shedding or disease, however, may result inappropriate high dose antiviral usage non-HSVP situations. We report a cohort of with positive BALF-HSV-PCR, its impact on role IDC use. Methods Retrospective chart review who had between 1/1/2018 8/31/2022. Exclusion criteria: No chest imaging (CT...
Abstract Background Microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying pathogen from plasma infected patients. Here, we describe potential impact a positive mcfDNA result on clinical decision making among immunocompromised adults with suspected pneumonia. Methods This prospective observational study evaluated utility in active hematological malignancies undergoing diagnostic bronchoscopy for pneumonia at 10 US Medical...
Abstract Background Beta-lactam allergy (BLA) is associated with increased broad-spectrum antibiotic (Br-ABX) use, worse clinical outcomes, and higher costs. Our hospital-wide BLA protocol (BLA-P) was launched in 7/2021 following categories: intolerance, low-risk (urticaria only >5 years ago, mild rash, remote childhood reaction limited details), high-risk (angioedema, anaphylaxis, severe rashes). Delabeling done directly based on history/interview alone (direct-delabeling), or via...
Abstract Background Pneumocystis jirovecii, an ubiquitous fungus, can lead to opportunistic pneumonia (PJP) in patients with hematological malignancies (HM) and hematopoietic cell transplantation (HCT) mild severe presentation. Unlike HIV, diagnosis of PJP is often challenging HM/HCT possibly related lower fungal burden versus atypical The gold standard for from bronchoalveolar lavage fluid (BALF) cytology, followed by direct fluorescent antigen (DFA), however, the context burden,...