A5061615033- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Herpesvirus Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Transplantation Outcomes and Treatments
- Quinazolinone synthesis and applications
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Autoimmune and Inflammatory Disorders Research
- Transplantation: Methods and Outcomes
- Research on Leishmaniasis Studies
- Toxoplasma gondii Research Studies
- Cancer Genomics and Diagnostics
- Antibiotic Resistance in Bacteria
- Immunodeficiency and Autoimmune Disorders
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
- Parvovirus B19 Infection Studies
- Bacillus and Francisella bacterial research
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
University of Colorado Denver
2018-2024
North Shore Hospital
2024
University of Colorado Anschutz Medical Campus
2018-2021
Stanford University
2016-2018
Standard testing fails to identify a pathogen in most patients with febrile neutropenia (FN). We evaluated the ability of Karius microbial cell-free DNA sequencing test (KT) infectious etiologies FN and its impact on antimicrobial management.This prospective study (ClinicalTrials.gov; NCT02912117) enrolled analyzed 55 FN. Up 5 blood samples were collected per subject within 24 hours fever onset (T1) every 2 3 days. KT results compared culture (BC) standard microbiological (SMT)...
Abstract Background Pneumonia is a common cause of morbidity and mortality, yet causative pathogen identified in minority cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield immunocompromised patients with pneumonia. Methods In this prospective, multicenter, observational study adults undergoing bronchoscopy to establish pneumonia etiology, plasma was compared standardized usual care testing. etiology adjudicated by blinded independent committee. The primary...
Clostridioides difficile infection (CDI) is a common complication in the hematopoietic stem cell transplantation (HSCT) and hematologic malignancy (HM) population. CDI associated with increased hospital length of stay, health care societal costs, morbidity, mortality. Identifying strategies for secondary prevention extreme importance HSCT/HM In this study, our primary objective was to evaluate effectiveness safety an oral vancomycin prophylaxis (OVP) protocol retrospective cohort adult...
<ns4:p>Vancomycin-resistant<ns4:italic>enterococcus</ns4:italic>(VRE) is now one of the leading causes nosocomial infections in United States. Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk VRE colonization and infection. has emerged as a major cause bacteremia this population, raising important clinical questions regarding role impact infection HSCT outcomes well optimal means prevention treatment. We review here published literature scientific advances...
Living kidney donation is possible for people living with HIV (PLWH) in the United States within research studies under Organ Policy Equity (HOPE) Act. There are concerns that donor nephrectomy may have an increased risk of end-stage renal disease (ESRD) PLWH due to HIV-associated and antiretroviral therapy (ART) nephrotoxicity. Here we report first 3 cases donors HOPE Act States. Within Action Multicenter Consortium, conducted a prospective study HIV. Pre-donation, estimated 9-year...
Abstract Background Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying in plasma. However, data are needed to define clinical scenarios where this tool offers highest benefit. Methods We conducted a prospective multicenter observational study that evaluated impact plasma mcfDNA compared with usual care testing among adults hematologic malignancies. This is secondary analysis an expanded cohort utility across...
BackgroundStandard microbiological testing (MT) fails to identify a pathogen in most chemotherapy recipients with febrile neutropenia (FN), who therefore receive prolonged empiric courses of broad-spectrum antimicrobials (AM). We evaluated the ability Karius next-generation sequencing plasma test (KT) infectious etiologies NF and its impact on AM management.
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) gram-negative bacteria may be transmitted from organ donors to solid transplant recipients are associated with poor outcomes post-transplant.We reported the prevalence of MDR/XDR respiratory colonization among 702 deceased in New York City area 2011 2014 performed chart reviews for a subset determine whether donor culture results were predictive subsequent recipient infection or used guide post-transplant antimicrobial...
Chagas disease (CD) is the third most common parasitic infection globally and can cause cardiac gastrointestinal complications. Around 300,000 carriers of CD live in U.S., with about 3000 those Colorado. We described our experience diagnosing at a Colorado teaching hospital to revise screening eligibility criteria. From 2006 2020, we reviewed Trypanosoma cruzi (TC) IgG serology results for 1156 patients institution. identified 23 (1.99%) who had positive test. A total 14/23 (60%) serologies...
Abstract Background Pneumonia is the most common infectious cause of morbidity and excess mortality complicating hematopoietic cell transplantation (HCT) treatment hematologic malignancy. Standard bronchoscopic noninvasive microbiologic testing identify causative pathogens in less than half cases. The Karius Test, a plasma next-generation sequencing assay microbial cell-free DNA, may improve diagnostic yield these patients. Methods Patients with active malignancy or recent HCT undergoing...
Blood cultures (BC) fail to detect a pathogen in most patients with neutropenic fever (NF). We examined the performance of Karius next generation sequencing plasma test (plasma NGS) compared that BC chemotherapy-induced NF. Patients 18 years or older absolute neutrophil count <500 cells/mm3 anticipated for > 7 days were enrolled at time collection (T0) due fever. Plasma samples collected T0 and twice weekly until recovery discharge. Samples shipped CLIA/CAP laboratory (Redwood City, CA)...
Abstract Purpose This study aims to evaluate the efficacy of a silver ion controlled release antimicrobial compound (AgG-CRC) applied surfaces in preventing surface colonization by multi-drug resistant microorganisms (MDRM) and reducing MDRM infection rates among patients admitted an intensive care unit (ICU). Methods We conducted five-month prospective 24-bed mixed ICU divided into two identical subunits (12 bed-boxes each). AgG-CRC was one subunit (Intervention Unit: IU), while other...
Staphylococcus aureus bacteraemia (SAB) remains a complex disease with high associated morbidity and mortality, especially when it is able to establish an occult nidus safe from antimicrobial eradication. Without rapid identification intervention, the can cause persistent relapse of disease, mortality. Having clinical suspicion for foci S. important, awareness potential sites infection critical be life-saving. We present unique case 65-year-old man end-stage renal receiving haemodialysis who...