A5078010967- Hypothalamic control of reproductive hormones
- Estrogen and related hormone effects
- Ovarian function and disorders
- Regulation of Appetite and Obesity
- Cell death mechanisms and regulation
- Neuroendocrine regulation and behavior
- Antioxidant Activity and Oxidative Stress
- Adipokines, Inflammation, and Metabolic Diseases
- Stress Responses and Cortisol
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Gene expression and cancer classification
- interferon and immune responses
- Cleft Lip and Palate Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Trace Elements in Health
- Congenital heart defects research
- Advances in Cucurbitaceae Research
- Menopause: Health Impacts and Treatments
- IL-33, ST2, and ILC Pathways
- Plant Reproductive Biology
- Diet, Metabolism, and Disease
- Reproductive System and Pregnancy
Memorial University of Newfoundland
2024-2025
University of Alberta
2024
City Of Hope National Medical Center
2022
University of California, San Francisco
2010-2021
University of California, Los Angeles
2010-2021
Neurological Research Institute
2021
University of Southern California
2004-2013
UCLA Health
2012
University of Connecticut
2009
University of Otago
2009
COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-expressing SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety immunogenicity in healthy adults.This combined open-label randomised, phase 1 trial done at the City of Hope Comprehensive Cancer Center (Duarte, CA, USA). We included participants aged 18-54 years with negative antibody PCR test, normal haematology chemistry panels, electrocardiogram troponin concentration, pregnancy test if female, body-mass...
Direct electronic access to multiple health record (EHR) systems through patient portals offers a novel avenue for decentralized research. Given the critical value of characterization, we sought compare computable evaluation conditions from patient-portal EHR against traditional self-report. In nationwide Innovative Support Patients with SARS-CoV-2 Infections Registry (INSPIRE) study, which linked self-reported questionnaires multiplatform data, compared across different clinical domains...
Stimulation of the Fas or tumor necrosis factor receptor 1 (TNFR1) cell surface receptors leads to activation death effector protease, caspase-8, and subsequent apoptosis. In some cells, Bcl-xL overexpression can inhibit anti-Fas- (TNF)-α-induced To address effect on caspase-8 processing, Fas- TNFR1-mediated apoptosis were studied in MCF7 breast carcinoma line stably transfected with human cDNA (MCF7/F) double cDNAs (MCF7/FB). strongly inhibited induced by either anti-Fas TNF-α. addition,...
The generation of oxidative stress by ambient air pollution particles contributes to the development allergic sensitization and asthma, as demonstrated intranasal challenge with well-characterized diesel exhaust particle (DEP) suspensions in humans. This effect is due presence redox active organic chemicals DEP, can be suppressed antioxidants inducers phase II enzymes animals. In this communication, we determined whether administration a standardized broccoli sprout extract (BSE), which...
Objective The brain reward circuits that promote drug abuse may also be involved in pleasure seeking behavior and food cravings observed severely obese subjects. Drug addiction polymorphisms such as the TaqI A1 allele of dopamine D 2 receptor ( DRD2 ) are associated with cocaine, alcohol, opioid use, but few studies have linked to craving. Other genes leptin gene LEPR mu‐opioid OPRM1 affect appetite centers influence obesity. three together function synergistically. Design Methods To...
The ability of the central nervous system to synthesize steroid hormones has wide-ranging implications for physiology and pathology. Among proposed roles neurosteroids is regulation LH surge. This involvement in estrogen-positive feedback demonstrates integration peripheral steroids with neurosteroids. Within female hypothalamus, estradiol from developing follicles stimulates progesterone synthesis astrocytes, which activate neural circuits regulating gonadotropin (GnRH) neurons. Estradiol...
P2X4 receptors are ATP-gated cation channels that widely expressed in the nervous system. To identify receptor-expressing cells, we generated BAC transgenic mice expressing tdTomato under control of receptor gene (<i>P2rx4</i>). We found sparse populations tdTomato-positive neurons most brain areas with patterns matched mRNA distribution. expression within microglia was low but increased by an experimental manipulation triggered microglial activation. surprisingly high hypothalamic arcuate...
Statements about building walls, deportation and denying services to undocumented immigrants made during President Trump's presidential campaign presidency may induce fear in Latino populations create barriers their health care access. To assess how these statements relate immigrants' (UDLI) legal residents/citizens' (LLRC) perceptions of safety presentations for emergency care, we conducted surveys adult patients at three county departments (EDs) California from June 2017 December 2018. Of...
Hass avocados are rich in monounsaturated fatty acids (oleic acid) and antioxidants (carotenoids, tocopherols, polyphenols) often eaten as a slice sandwich containing hamburger or other meats. Hamburger meat forms lipid peroxides during cooking. After ingestion, the stomach functions bioreactor generating additional this process can be inhibited when ingested together with meat. The present pilot study was conducted to investigate postprandial effect of addition 68 g avocado on vasodilation...
Abstract The neuropeptide kisspeptin is essential for sexual maturation and reproductive function. In particular, kisspeptin-expressing neurons in the anterior rostral periventricular area of third ventricle are generally recognized as mediators estrogen positive feedback surge release LH, which stimulates ovulation. Estradiol induces expression but suppresses arcuate nucleus that regulate estrogen-negative feedback. To focus on intracellular signaling response to estradiol underlying...
The medial prefrontal cortex (MPF) regulates emotions, stress responses, and goal-directed behaviors like attention decision-making. However, the precise mechanisms underlying MPF function remain poorly understood, largely due to an incomplete characterization of its neural circuitry. Leveraging neuroanatomical, neurophysiological, behavioral techniques, we present a detailed wiring diagram MPF, with particular focus on dorsal peduncular area (DP), underexplored implicated in psychological...
The mechanism by which membrane-bound Bcl-2 inhibits the activation of cytoplasmic procaspases is unknown. Here we characterize an intracellular, membrane-associated form procaspase-3 whose controlled Bcl-2. Heavy membranes isolated from control cells contained a spontaneously activatable caspase-3 zymogen. In contrast, in overexpressing cells, although zymogen was still associated with heavy membranes, its spontaneous blocked. However, expression had little effect on levels caspase activity...
Positive feedback on gonadotropin release requires not only estrogen but also progesterone to activate neural circuits. In rodents, ovarian estradiol (E2) stimulates synthesis in hypothalamic astrocytes (neuroP), needed for the luteinizing hormone (LH) surge. Kisspeptin (kiss) neurons are principal stimulators of gonadotropin-releasing neurons, and disruption kiss signaling abrogates LH Similarly, blocking steroid hypothalamus or deleting classical receptor (PGR) selectively prevents These...
Rodent models show decreased neuronal responses to estradiol (E2) during aging (E2-desensitization) in association with reduced estrogen receptor (ER)-α, but little is known about age changes of E2-dependent astrocytic neurotrophic support. Because elevated expression astrocyte glial fibrillary acidic protein (GFAP) associated impaired activity and because the GFAP promoter responds ERα, we investigated role ERα ERβ aging. In vivo vitro, was increased greater than 50% astrocytes from...
Progesterone (P4) antagonizes estradiol (E2) in synaptic remodeling the hippocampus during rat estrous cycle. To further understand how P4 modulates plasticity, we used entorhinal cortex lesions, which induce E2-dependent neurite sprouting hippocampus. In young ovariectomized rats, lesion-induced was attenuated by concurrent treatment with and E2. Microglial activation also showed E2-P4 antagonism. These findings extend reports on cycle without lesions showing P4-E2 antagonism simultaneous...
Rabdosia rubescens is a herbal root extract of traditional Chinese medicine (TCM) used to treat inflammatory diseases and oral cancers. A key principle TCM that multiple ingredients in plant are more effective less toxic than single purified active ingredient or drug derived from product. (RRE) contains terpenoids flavonoids, but the most within attributed inhibition cancer kaurene diterpene, oridonin. In order research synergy with complete extract, effects RRE on prostate cell...