A5090919037- Immune responses and vaccinations
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Caveolin-1 and cellular processes
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Congenital heart defects research
- COVID-19 and healthcare impacts
- Influenza Virus Research Studies
- Digestive system and related health
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Cancer Research and Treatments
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Tuberculosis Research and Epidemiology
- Polyomavirus and related diseases
- Immunodeficiency and Autoimmune Disorders
- Healthcare cost, quality, practices
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Cancer therapeutics and mechanisms
- Inflammatory Biomarkers in Disease Prognosis
Memorial Sloan Kettering Cancer Center
2013-2024
Office of Infectious Diseases
2024
New York Proton Center
2024
Cornell University
2018-2020
As of 10 April 2020, New York State had 180,458 cases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% deceased individuals1. Population-based studies from China Italy suggested a higher disease 2019 (COVID-19) death rate in patients cancer2,3, although there is knowledge gap as to which aspects its treatment confer risk COVID-194. This information critical balance the competing safety considerations reducing...
The risk of infection among patients receiving immune checkpoint blockade is unknown. We retrospectively reviewed medical records 740 with melanoma who received blockers. Serious occurred in 54 (7.3%). main factors were receipt corticosteroids and/or infliximab.
Ibrutinib is a Bruton tyrosine kinase inhibitor that used for the treatment of lymphoid cancers, including chronic lymphocytic leukemia, Waldenström macroglobulinemia, and mantle cell lymphoma. Several case series have described opportunistic infections among ibrutinib recipients, but full extent these unknown. We sought to determine spectrum serious associated with treatment.We reviewed electronic medical records patients cancer at Memorial Sloan Kettering Cancer Center who received during...
Abstract Bacille Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that used widely as a vaccine for tuberculosis and effective treatment superficial bladder carcinoma. Despite being the most successful cancer biotherapy, its mechanism action response determinants remain obscure. Here, we establish model system to analyze BCG interaction with cells, using it show these cells vary dramatically in their susceptibility infection. Unexpectedly, uptake by occurs...
Macropinocytosis has emerged as an important pathway of protein acquisition in cancer cells, particularly tumors with activated Ras such pancreatic and colon cancer. is also the route entry Bacillus Calmette-Guerin (BCG) other microbial therapies Despite this role tumor biology therapy, full mechanisms by which cells can activate macropinocytosis remain incompletely defined. Using BCG uptake to assay macropinocytosis, we executed a genome-wide shRNA screen for activators identified Wnt...
Significance Bacillus Calmette–Guérin (BCG) therapy is one of the oldest tumor immunotherapies, but its mechanism remains unknown. Herein we show that BCG induces tumor-specific T cell-dependent immunity predominantly mediated by CD4 cells in a manner distinct from other immunotherapies. These immunologic insights may allow investigation into biomarkers could predict efficacy human cancer patients.
Bacterial pathogens rely on their DNA repair pathways to resist genomic damage inflicted by the host. double-strand breaks (DSBs) are especially threatening bacterial viability. DSB homologous recombination (HR) requires nucleases that resect ends and a strand exchange protein facilitates homology search. RecBCD RecA perform these functions in Escherichia coli constitute major pathway of error-free repair. Mycobacteria, including human pathogen M. tuberculosis, elaborate an additional...
Background. Rapidly growing mycobacteria (RGM) have been associated with various clinical syndromes in immunocompetent and immunocompromised hosts. The risk factors outcomes of RGM infection patients cancer not clearly defined.
New York State had 180,458 cases of SARS-CoV-2 and 9385 reported deaths as April 10 th , 2020. Patients with cancer comprised 8.4% deceased individuals 1 . Population-based studies from China Italy suggested a higher COVID-19 death rate in patients 2,3 although there is knowledge gap to which aspects its treatment confer risk severe disease 4 This information critical balance the competing safety considerations reducing exposure continuation. Since March 2020 Memorial Sloan Kettering Cancer...
The tumor suppressor PTEN is a lipid phosphatase that frequently mutated in various human cancers. suppresses cell proliferation, survival, and growth mainly by inhibiting the PI3K-Akt signaling pathway through dephosphorylation of phosphatidylinositol 3,4,5-triphosphate. In addition to it role suppression, PTEN-PI3K controls many cellular functions, some which may be important for resistance infection. Currently, intersection between tumorigenic pathways susceptibility infection not well...
Intratumoral therapy with oncolytic viruses is increasingly being explored as a strategy to potentiate an immune response against cancer, but it remains unknown whether such should be restricted cancers sensitive virus-mediated lysis. Using Newcastle Disease Virus (NDV) model, we explore immunogenic potential of virus in bladder where existing immunotherapy PD-1 and PD-L1-targeting antibodies date has shown suboptimal rates. Infection human mouse cancer cells NDV resulted cell death,...
Summary Mycobacterium bovis BCG is the vaccine against tuberculosis and an immunotherapy for bladder cancer. When administered intravenously, reprograms bone marrow hematopoietic stem progenitor cells (HSPCs), leading to heterologous protection infections. Whether HSPC-reprogramming contributes anti-tumor effects of into unknown. We demonstrate that in both mice humans HSPCs amplify myelopoiesis functionally enhance myeloid cell antigen presentation pathways. Reconstitution naive with from...
To investigate what findings are new on contrast-enhanced abdominopelvic CT in patients infected with SARS-CoV-2.Contrast-enhanced of the abdomen and pelvis COVID-19 at a tertiary oncologic center acquired over 2-month period were reviewed independently by two readers scored for imaging abnormalities compared prior scan. scans included if study was performed between - 3 45 days from time diagnosis. Clinical information gathered medical records.A total 63 (34 male, 29 female; mean age 60.6...
For decades, BCG immunotherapy has been the standard of care for non-muscle-invasive bladder cancer. Despite this clinical experience, mechanism by which stimulates tumor-eliminating immunity is unclear, and there still a need more accurate prediction outcomes in advance treatment initiation. We have shown that tumor-specific T-cell requires tumor cell expression IFNγ receptor (IFNGR); however, downstream components IFNGR signaling responsible responsiveness to are unknown. Here, we...