A5080992635- Immune responses and vaccinations
- Trypanosoma species research and implications
- Immune cells in cancer
- Plant Virus Research Studies
- HIV/AIDS drug development and treatment
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Protein Degradation and Inhibitors
- SARS-CoV-2 and COVID-19 Research
Cornell University
2022-2024
Weill Cornell Medicine
2022-2024
Microbial ID (United States)
2024
New York Proton Center
2024
Harvey Mudd College
2022
Summary Mycobacterium bovis BCG is the vaccine against tuberculosis and an immunotherapy for bladder cancer. When administered intravenously, reprograms bone marrow hematopoietic stem progenitor cells (HSPCs), leading to heterologous protection infections. Whether HSPC-reprogramming contributes anti-tumor effects of into unknown. We demonstrate that in both mice humans HSPCs amplify myelopoiesis functionally enhance myeloid cell antigen presentation pathways. Reconstitution naive with from...
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic inflammation and can result in protracted symptoms. Robust may trigger persistent changes hematopoietic cells innate immune memory through epigenetic mechanisms. We reveal that rare circulating stem progenitor (HSPC), enriched from human blood, match the diversity of HSPC bone marrow, enabling investigation hematopoiesis epigenomics. Following COVID-19, retain epigenomic alterations are conveyed,...
Trypanosoma brucei, the causative agent of human and animal African trypanosomiasis, cycles between a mammalian host tsetse fly vector. The parasite undergoes huge changes in morphology metabolism during adaptation to each environment. These are reflected different transcriptomes parasites living host. However, it remains unclear whether chromatin-interacting proteins help mediate these changes. Bromodomain localize transcription start sites bloodstream parasites, but localization...
Abstract Trypanosoma brucei , the causative agent of Human and Animal African trypanosomiasis, cycles between a mammalian host tsetse fly vector. The parasite undergoes huge changes in morphology metabolism as it adapts to each environment. These are reflected differing transcriptomes parasites living host. While transcriptome have been well catalogued for differentiating from bloodstream insect stage, remains unclear whether chromatin interacting proteins mediate transcriptomic during life...