A5092661010- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Reproductive tract infections research
- Immune cells in cancer
- T-cell and B-cell Immunology
- Parasitic Infections and Diagnostics
- Immune responses and vaccinations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Impact on Reproduction
- interferon and immune responses
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
Memorial Sloan Kettering Cancer Center
2023-2025
Weill Cornell Medicine
2024
Cornell University
2024
Kettering University
2023
Chlamydia muridarum (Cm), an intracellular bacterium of historical importance, was recently rediscovered as moderately prevalent in research mouse colonies. Cm first reported a causative agent severe pneumonia mice about 80 y ago, and while it has been used experimentally to model trachomatis infection humans, there have no further reports clinical disease associated with natural infection. We observed pathology 2 genetically engi- neered (GEM) strains, Il12rb2 KO STAT1 KO, impaired...
Chlamydia muridarum (Cm), an intracellular bacterium of historical importance, was recently rediscovered as moderately prevalent in research mouse colonies. Cm first reported a causative agent severe pneumonia mice about 80 y ago, and while it has been used experimentally to model trachomatis infection humans, there have no further reports clinical disease associated with natural infection. We observed pathology 2 genetically engineered (GEM) strains, Il12rb2 KO STAT1 KO, impaired...
Abstract Interleukin-10 (IL-10) is pivotal in suppressing inflammation and innate immune activation, large part by induction of genes potent inflammatory factors such as TLR ligands. Despite decades research, molecular mechanisms underlying this inhibition have not been resolved. This study utilized an integrated epigenomic analysis gene transcription, chromatin accessibility, histone modifications transcription factor binding to investigate IL-10-mediated suppression LPS TNF responses...
Abstract The regulation of inflammatory gene expression involves complex interactions between transcription factors (TFs), signaling pathways and epigenetic chromatin-mediated mechanisms. This study investigated mechanisms by which IFN-γ-mediated priming augments TLR-induced NF-κB target genes in primary human monocytes. IFN-γ enhanced the signature such as IL6 , TNF IL1B CXCL10 when monocytes were exposed to various TLR agonists. RNA-seq analysis identified synergistically activated LPS,...
Abstract Natural killer (NK) cells are circulating innate lymphocytes that poised to respond rapidly upon encounter with cancer or virally-infected as well proinflammatory cytokines. In addition their early role in immune responses, it is now appreciated NK can also take on features of adaptive such antigen-specific clonal expansion and long-lived memory these processes best characterized following cytomegalovirus (CMV) infection mouse human. cell receptor recognition virally-encoded...