A5022289846- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Eosinophilic Esophagitis
- vaccines and immunoinformatics approaches
- Genomics and Chromatin Dynamics
- Multiple Myeloma Research and Treatments
- Inflammasome and immune disorders
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Protein Degradation and Inhibitors
- RNA and protein synthesis mechanisms
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
Leibniz Association
2018-2024
German Rheumatism Research Centre
2017-2024
Charité - Universitätsmedizin Berlin
2020-2024
Bayer (Germany)
2017
German National Academic Foundation
2016
Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory is a hallmark adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural killer (NK) cell to human cytomegalovirus (HCMV) infection. Leveraging single-cell multiomic maps ex vivo NK somatic mitochondrial DNA mutations endogenous barcodes, reveal substantial clonal in HCMV
Natural killer (NK) cells are innate immune that contribute to host defense against virus infections. NK respond severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and activated patients with disease 2019 (COVID-19). However, by which mechanisms detect SARS-CoV-2-infected remains largely unknown. Here, we show the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide is presented human leukocyte antigen E (HLA-E). In contrast self-peptides, viral prevents binding...
Abstract HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown can present diverse peptides to NK cells T cells, the repertoire recognized by CD94/NKG2x has remained poorly defined, with only limited number of peptide ligands identified. Here we screen yeast-displayed library context identify 500 high-confidence unique that bind both CD94/NKG2A or CD94/NKG2C. Utilizing sequences identified via yeast display...
Metabolic changes are linked to epigenetic reprogramming and play important roles in several tumor types. PGC-1α is a transcriptional coactivator controlling mitochondrial biogenesis oxidative phosphorylation. We provide evidence that melanoma models with elevated levels characteristic of the proliferative phenotype sensitive bromodomain extra-terminal domain (BET) inhibitor treatment. A super-enhancer region highly occupied by BET family member BRD4 was identified for gene. treatment...
Human cytomegalovirus (HCMV) may cause severe infections in lung transplant recipients (LTRs). In response to HCMV infections, a subset of NKG2C+ NK cells expands, which limits replication and is characterized by high expression the activating NKG2C/CD94 absence inhibitory NKG2A/CD94 receptor. Both receptors bind HLA-E, stabilized HCMV-encoded UL40 peptides. HLA-E occur as different genetic variants. this study, we investigated interplay between human cell infecting HCMV-UL40 strain,...
Abstract The OX40-OX40L pathway provides crucial co-stimulatory signals for CD4 T cell responses, however the precise cellular interactions critical OX40L provision in vivo and when these occur, remains unclear. Here, we demonstrate that of by dendritic cells (DCs), but not cells, B nor group 3 innate lymphoid (ILC3s), is specifically effector Th1 response to an acute systemic infection with Listeria monocytogenes (Lm). expression DCs regulated cross-talk NK IFNγ signalling DC enhance a...
Human cytomegalovirus (HCMV) infection induces adaptations in the natural killer (NK)-cell compartment. Expanded subsets of adaptive NK cells display potent effector functions against cellular targets, despite their apparent unresponsiveness to stimulation with classical dendritic cell-derived cytokines interleukin (IL)-12 and IL-18. However, it remains unclear whether have completely lost ability sense inflammation via IL-12 IL-18 or these pro-inflammatory signals can be functionally...
Regulatory T cells (T reg cells) hold promise for sustainable therapy of immune disorders. Recent advancements in chimeric antigen receptor development and genome editing aim to enhance the specificity function cells. However, impurities functional instability pose challenges safe gene-edited cell products. Here, we examined different subsets regarding their fate, epigenomic stability, transcriptomes, repertoires, ex vivo after manufacturing. Each subset displayed distinct features,...
Abstract HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown can present diverse peptides to NK cells T cells, the receptor peptide repertoire has remained poorly defined, with only limited number of ligands identified. Here we screen yeast-displayed library context identify 500 high-confidence unique that bind both CD94/NKG2A or CD94/NKG2C. Utilizing sequences identified via yeast display selections, train...