A5106986659- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
German Rheumatism Research Centre
2024
Charité - Universitätsmedizin Berlin
2024
Leibniz Association
2024
Regulatory T cells (T reg cells) hold promise for sustainable therapy of immune disorders. Recent advancements in chimeric antigen receptor development and genome editing aim to enhance the specificity function cells. However, impurities functional instability pose challenges safe gene-edited cell products. Here, we examined different subsets regarding their fate, epigenomic stability, transcriptomes, repertoires, ex vivo after manufacturing. Each subset displayed distinct features,...