A5083349998- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Glutathione Transferases and Polymorphisms
- Curcumin's Biomedical Applications
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Antioxidant Activities
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Bioactive Compounds in Plants
- Pharmacological Effects of Natural Compounds
- Bioactive natural compounds
- Inflammatory mediators and NSAID effects
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Ginger and Zingiberaceae research
- Antioxidant Activity and Oxidative Stress
- Traditional Chinese Medicine Analysis
- Fungal Biology and Applications
- Diet and metabolism studies
- Medicinal Plant Pharmacodynamics Research
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Bioactive Compounds and Antitumor Agents
- Circular RNAs in diseases
Chung Yuan Christian University
2015-2025
Guangdong University of Technology
2014-2025
Xiamen Maternal and Child Health Hospital
2020
Rutgers, The State University of New Jersey
2010-2018
National Taiwan University
2008-2013
Institute of Food Science and Technology
2011
Hormel (United States)
2010
Jeonbuk National University
2010
University of Minnesota
2010
China Medical University
2008
Nrf2 is a transcription factor that plays critical roles in regulating the expression of cellular defensive antioxidants and detoxification enzymes. However, role Nrf2's epigenetics reprogramming skin tumor transformation unknown. In this study, we investigated inhibitory on induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) mouse epidermal JB6 (JB6 P+) cells anticancer effect sulforaphane (SFN), an isothiocyanate found cruciferous vegetables. After five days treatment, SFN significantly...
Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of cancer. Curcumin, a dietary phytochemical, shows promising effects suppressing colitis-associated cancer azoxymethane-dextran sulfate sodium (AOM-DSS) mice. However, potential epigenetic curcumin remain unknown. In this study, anticancer effect 18-week AOM-DSS mouse model was confirmed. We identified lists differentially expressed methylated...
Abstract Apigenin (API) and luteolin (LUT) have been used as therapeutic agents in folk medicine for thousands of years. These compounds exert a variety biological activities, including anticancer, antioxidant antiinflammatory activities. This study investigated whether API LUT could activate Nrf2‐antioxidant response element (ARE)‐mediated gene expression induce activities human hepatoma HepG2 cells. The did not exhibit any substantial toxicity at low doses (1.56–6.25 µ m ). induction ARE...
Cancer development has been linked to epigenetic modifications of cancer oncogenes and tumor suppressor genes; in advanced metastatic cancers, severe are present. We previously demonstrated that the progression prostate tumors TRAMP mice is associated with methylation silencing Nrf2 promoter a reduced level transcription target genes. Radix Angelicae Sinensis (RAS; Danggui) medicinal herb health food supplement widely used Asia for centuries. Z-Ligustilide (Lig) one bioactive components RAS....
Green tea is a highly popular beverage globally. contains number of polyphenol compounds referred to as catechins, and (-)-epigallocatechin gallate (EGCG) believed be the major biologically active compound found in green tea. EGCG has been reported suppress lung cancer, but molecular mechanisms inhibitory effects are not clear. We that interacted with Ras-GTPase-activating protein SH3 domain-binding 1 (G3BP1) high binding affinity (K(d) = 0.4 micromol/L). also showed suppressed...
Ginseng has long been used in Asian countries for more than 2000 years. Currently, the "Western World or Western Medicines", many reports have indicated that they herbal medicines, and ginseng is one of most popular herbs. Several recent antioxidant/antioxidative stress activities play a role benefits ginseng; however, precise mechanism lacking. The antioxidant response element (ARE) critical regulatory expression enzymes phase II/III drug metabolizing/transporter genes, mediated by...
Nrf2 plays a critical role in defending against oxidative stress and inflammation. We previously reported that confers protection ultraviolet-B (UVB)-induced inflammation, sunburn reaction, is involved sulforaphane-mediated photo-protective effects the skin. In this study, we aimed to demonstrate protective of inflammation-mediated extracellular matrix (ECM) damage induced by UVB irradiation. Ear biopsy weights were significantly increased both wild-type (Nrf2 WT) knockout KO) mice one week...
Colorectal cancer (CRC) is the third most common worldwide. Chronic inflammation appears to enhance risk of CRC. Emerging evidence has suggested that epigenetic mechanisms play an important role in Aspirin [acetylsalicylic acid (ASA)] been shown prevent CRC; however, its action remain unknown. This study investigated protective ASA azoxymethane (AOM)-initiated and dextran sulfate sodium (DSS)-promoted colitis-associated colon (CAC) examined effects, particularly on histone 3 lysine 27...
Abstract BACKGROUND Many diseases may be caused by pathogens and oxidative stress resulting from carcinogens. Earlier studies have highlighted the antimicrobial antioxidant effects of plant essential oils (EO). It is crucial to effectively utilize agricultural waste achieve a sustainable economy protect environment. The present study aimed evaluate potential benefits EO extracted discarded peels Citrus depressa Hayata (CD) microcarpa Bunge (CM), synonyms deliciosa Ten japonica Thunb,...
ABSTRACT The root of Angelica sinensis (Oliv.) Diels (abbreviated as AS) (Danggui) has a long history in Asian herbal medicine. Recently, it was demonstrated that AS possesses anti‐cancer and anti‐oxidant activities. Because the transcription factor Nrf2 mediates expression many cellular anti‐oxidative stress genes, including genes are involved phase II drug metabolism stress, this study sought to investigate whether pure compounds from or an extract could activate antioxidant response...
Studies during the last two decades have revealed involvement of epigenetic modifications in development human cancer. It is now recognized that interplay DNA methylation, post-translational histone modification, and non-coding RNAs can interact with genetic defects to drive tumorigenesis. The early onset, reversibility, dynamic nature such enable them be developed as promising cancer biomarkers preventive/therapeutic targets. In addition recent approval several therapies treatment cancer,...
It has previously been shown that curcumin can effectively inhibit prostate cancer proliferation and progression in TRAMP mice, potentially acting through the hypomethylation of Nrf2 gene promoter hence activation pathway to enhance cell antioxidative defense. FN1 is a synthetic analogue shows stronger anticancer activity than other reports. We aimed explore epigenetic modification restores expression TRAMP-C1 cells. Stably transfected HepG2-C8 cells were used investigate effect on Nrf2-...