A5101737146- Malaria Research and Control
- Ginger and Zingiberaceae research
- Mosquito-borne diseases and control
- Genetic Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolism, Diabetes, and Cancer
- Drug-Induced Hepatotoxicity and Protection
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
- Medicinal plant effects and applications
- Cellular transport and secretion
- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Natural Products and Biological Research
- Transgenic Plants and Applications
- Botulinum Toxin and Related Neurological Disorders
- Cannabis and Cannabinoid Research
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
Dongguk University
2014-2024
University of Minnesota
2020-2022
Rutgers, The State University of New Jersey
2015-2022
Universidad de Oviedo
2022
University of Minnesota System
2022
Instituto de Investigación Sanitaria del Principado de Asturias
2022
Hanyang University
2013-2016
Samsung (South Korea)
2015
Kyung Hee University Medical Center
2013
Jungwon University
2010-2012
Background/Aims Hepatitis B virus (HBV) is the major cause of chronic liver disease in Korea, but viral prevalence has decreased because hepatitis vaccination programs. In this study, we investigated longitudinal changes HBV fection general Korean population. Methods surface antigen (hepatitis antigen, HBsAg) seropositivity was assessed from Korea National Health and Nutrition Examination Survey (I to V). total, 50,140 subjects were tested for serum HBsAg positivity over a period 12 years...
Scope Tumor metastasis greatly contributes to the mortality of prostate cancer. The glucosinolate‐derived phenethyl isothiocyanate (PEITC) has been widely documented reduce risk cancer by modulating multiple biologically relevant processes. Emerging evidence suggests that PEITC may exert its anti‐cancer effects through epigenetic mechanisms including microRNAs. Altered levels miRNA have linked tumor malignancy due their capacity regulate functional gene expression in carcinogenesis. Here, we...
Seven cases of surgically proven sparganosis were serologically tested by means micro ELISA for their specific IgG antibody levels. For that purpose, crude saline extract spargana from snake, Natrix tigrina lateralis was prepared and used as antigen. The sera also with Paragonimus Cysticercus antigens to observe the cross reactivity. A total 71 normal control, ectopic pulmonary paragonimiasis, clonorchiasis, cysticercosis Taenia saginata included. Except one case old calcified infection, all...
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. mutation causes protein misfolding and aggregation, preferentially affecting medium spiny neurons (MSNs) of basal ganglia. Transcriptional perturbations synaptic genes neuroinflammation key processes that precede MSN dysfunction motor symptom onset. Understanding interplay between these crucial to develop effective therapeutic...
Stromal cell-derived growth factor 1 (SDF-1), also known as chemokine ligand 12, and receptor type 4 are involved in cancer cell migration. Compound K (CK), a metabolite of protopanaxadiol-type ginsenoside by gut microbiota, is reported to have therapeutic potential therapy. However, the inhibitory effect CK on SDF-1 pathway-induced migration glioma has not yet been established.Cytotoxicity C6 cells was determined using an EZ-Cytox viability assay kit. Cell tested wound healing Boyden...
In this study, the anti-oxidative activities of 70% ethanol extract from Curcuma aromatica Salisb. (CAS) and curcumin (CUR) were studied. The CAS extracts CUR both found to have a potent scavenging activity against reactive species tested, as well an inhibitory effect on LDL oxidation. Cultured human umbilical vein endothelial cells (HUVECs) stimulated with tumour necrosis factor α (TNFα), expression intracellular oxygen (ROS), nitric oxide (NO), synthase (eNOS), lectin-like oxidised...
Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome. In this study, we investigated histological and biochemical changes in NAFLD the gene expression involving de novo lipogenesis Otsuka Long-Evans Tokushima (OLETF) rats. We used OLETF rats (LETO) as animal models controls, respectively. Consistent observations were made at 4-week intervals up to 50 weeks age, all fed ad libitum with standard food. Biochemical observed, involved was measured...
The proliferation and migration of vascular smooth muscle cells (VSMCs) in blood vessels are important the pathogenesis disorders such as atherosclerosis restenosis. Piperine, a major component black pepper, has antioxidant, anticancer, anti-inflammatory activity. However, antiatherosclerotic effects piperine have not been investigated. In this study, on platelet-derived growth factor (PDGF)-BB-induced VSMCs were antiproliferative determined using MTT assays, cell counting, real-time...
Cannabis has been cultivated for thousands of years a variety purposes, including fiber, seeds, oil, and medicinal compounds. The cannabis industry is growing rapidly because several countries have recently legalized the use cannabis. In these countries, related to cannabinoid ingredients such as cannabidiol (CBD) Δ9-tetrahydrocannabinol (THC) steadily increasing every year. High concentrations cannabinoids are mainly produced in unfertilized female flowers. Maintaining plants with high...
To investigate the anti-inflammatory effects and action mechanism of fruits Hovenia dulcis (H. dulcis) in lipopolysaccharide (LPS)-induced mouse macrophage Raw 264.7 cells.The extract H. (EHDF) were extracted with 70% ethanol. Mouse macrophages treated different concentrations EHDF presence absence LPS (1 μg/mL). demonstrate inflammatory mediators including nitric oxide, inducible oxide synthase cyclooxygenase (COX)-2 expression levels analyzed by using vitro assay systems. COX-derived...
Medicinal herb-derived drug development has become important in the relief of liver pathology. Amomun cardamomum is traditionally used therapeutically Korea to treat various human ailments including dyspepsia, hiccupping, and vomiting. We investigated assess protective effect A. on carbon tetrachloride (CCl4)-induced damage through antioxidant activity hepatic tissues Sprague-Dawley rats.Antioxidant properties different fractions from ethanol extracts were evaluated by an vitro free radical...
To develop a plant-based vaccine against Plasmodium vivax, two P. vivax candidate proteins were chosen. First, the merozoite surface protein-1 (MSP-1), major asexual blood stage antigen that is currently considered strong candidate. Second, circumsporozoite protein (CSP), component of sporozoites contains B-cell epitope. A synthetic chimeric recombinant 516 bp gene encoding containing PvMSP-1, Pro-Gly linker motif, and PvCSP was synthesized; gene, named MLC, encoded total 172 amino acids....
Despite its deleterious effects on living cells, oxidative stress plays essential roles in normal physiological processes and provides signaling molecules for cell growth, differentiation, inflammation. Macrophages are equipped with antioxidant mechanisms to cope intracellular ROS produced during immune response, Nrf2 (NF‐E2‐related factor 2)/HO‐1 (heme oxygenase‐1) pathway is an attractive target due protective effect against ROS‐induced damage inflamed macrophages. We investigated the of...
Abstract Background Plasmodium vivax is divided into two subtypes, a dominant form, VK210 and variant VK247. This division dependent on the amino acid composition of circumsporozoite (CS) protein. In this study, prevalence VK247 form P. was investigated in Myanmar. Methods The existence malaria parasites blood samples determined by microscopic examination, polymerase chain reaction (PCR) DNA hybridization assays. To test for antibodies against falciparum samples, an indirect...
Postsynaptic density 95 (PSD-95), the major scaffold protein at excitatory synapses, plays a role in mediating intracellular signaling by synaptic N-methyl-d-aspartate (NMDA) type glutamate receptors. Despite fact that much is known about of PSD-95 NMDA-mediated toxicity, less its mechanical injury, and more specifically, traumatic brain injury (TBI). Given neural circuitry disrupted after TBI interactors end-binding 3 (EB3) adenomatous polyposis coli (APC) shape dendrites, we examined...
Targeting Toll-like receptor 4/myeloid differentiation factor 2 (TLR4/MD2) signaling is regarded as a potential strategy for treating inflammatory diseases. Saponaria officinalis L. rich in saponin, which include quillaic acid, gypsogenin, saponarin, and hederagenin. We evaluated the pharmacological activity of extract THP-1 derived macrophages RAW264.7 macrophages. TLR4/MyD88 complex formation downstream signals were investigated by co-immunoprecipitation (Co-IP). In silico docking...
The proliferation of vascular smooth muscle cells (VSMCs) plays a key role in the development atherosclerosis. Abnormal VSMC induces dysfunction and several other pathological processes. present study investigated apoptotic effects genistein on tumor necrosis factor-α (TNF-α)-induced human aortic (HASMCs). were assessed to determine mechanism(s) its antiproliferative activity, including MTT, LDH assay, morphological change cell, DNA fragmentation, expression levels pro- or anti-apoptotic...
Objectives: Cannabis root is a medicinal plant that has been used in traditional medicine around the world. However, previous studies using simple extracts, biological activity was not relatively prominent compared to other herbal medicines. The aim of present study confirm enhancement anti-inflammatory and bioactive compound extract prepared by combined processing process.Methods: A series processes including repeated steam dry, fermentation, hydrothermal extraction ethanol applied root....
Abstract New drug development is a challenging process that requires high-risk, huge costs and long lead times. Therefore, repurposing considered strategic economic way towards successful development. Sochehwan (SCH) herbal formula well known as digestive aid in traditional oriental medicine, referred to classic medical texts, available an over-the-counter for indications of ailments. Interestingly, another text written earlier age describes different indication SCH yet be examined. We...