A5042331693- Genetic Neurodegenerative Diseases
- Transgenic Plants and Applications
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Heat shock proteins research
- Parkinson's Disease Mechanisms and Treatments
- Plant tissue culture and regeneration
- Viral Infectious Diseases and Gene Expression in Insects
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Advanced MRI Techniques and Applications
- Insect Resistance and Genetics
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- CRISPR and Genetic Engineering
University of Minnesota Medical Center
2021-2023
University of Minnesota System
2022
University of Minnesota
2020-2022
Inha University
2008
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. mutation causes protein misfolding and aggregation, preferentially affecting medium spiny neurons (MSNs) of basal ganglia. Transcriptional perturbations synaptic genes neuroinflammation key processes that precede MSN dysfunction motor symptom onset. Understanding interplay between these crucial to develop effective therapeutic...
p53 and HSF1 are two major transcription factors involved in cell proliferation apoptosis, whose dysregulation contributes to cancer neurodegeneration. Contrary most cancers, is increased Huntington's disease (HD) other neurodegenerative diseases, while decreased. reciprocal regulation has been shown different contexts, but their connection neurodegeneration remains understudied. Using cellular animal models of HD, we show that mutant HTT stabilized by abrogating the interaction between E3...
PSD-95 (Dlg4) is an ionotropic glutamate receptor scaffolding protein essential in synapse stability and neurotransmission. levels are reduced during aging neurodegenerative diseases like Huntington’s disease (HD), it believed to contribute synaptic dysfunction behavioral deficits. However, the mechanism responsible for dysregulation under these conditions unknown. The Heat Shock transcription Factor 1 (HSF1), canonically known its role homeostasis, also depleted both HD. Synaptic levels,...
Striatal medium spiny neurons are highly susceptible in Huntington's disease (HD), resulting progressive synaptic perturbations that lead to neuronal dysfunction and death. Non-invasive imaging techniques, such as proton magnetic resonance spectroscopy (
Abstract Background Huntington’s Disease (HD) is a neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. This mutation causes protein misfolding and aggregation, preferentially affecting medium spiny neurons (MSNs) of basal ganglia. Transcriptional perturbations synaptic genes neuroinflammation key processes that precede MSN dysfunction motor symptom onset. Understanding interplay between these crucial to develop...
PSD-95 (Dlg4) is an ionotropic glutamate receptor scaffolding protein essential in synapse stability and neurotransmission. levels are reduced during aging neurodegenerative diseases like Huntington’s disease (HD), it believed to contribute synaptic dysfunction behavioral deficits. However, the mechanism responsible for dysregulation under these conditions unknown. The Heat Shock transcription Factor 1 (HSF1), canonically known its role homeostasis, also depleted both HD. Synaptic...
Abstract Striatal medium spiny neurons are highly susceptible in Huntington’s disease (HD), resulting progressive synaptic perturbations that lead to neuronal dysfunction and death. Non-invasive imaging techniques, such as proton magnetic resonance spectroscopy ( 1 H-MRS), used HD mouse models patients with monitor neurochemical changes associated health. However, the association between brain alterations dysregulation is unknown, limiting our ability potential treatments may affect synapse...
Summary p53 and HSF1 are two major transcription factors involved in cell proliferation apoptosis, whose dysregulation contributes to cancer neurodegeneration. Contrary cancer, is increased Huntington’s disease (HD) other neurodegenerative diseases, while decreased. Reciprocal regulation between was shown different contexts, but their connection neurodegeneration remained unexplored. Using cellular animal models of HD, we showed that mutant HTT stabilized by abrogating the interaction...