A5014215045- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Heat shock proteins research
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Abdominal Trauma and Injuries
- Advanced MRI Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Botulinum Toxin and Related Neurological Disorders
University of Minnesota
2019-2023
University of Minnesota Medical Center
2021-2023
University of Minnesota System
2022
The University of Texas at Austin
2019
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. mutation causes protein misfolding and aggregation, preferentially affecting medium spiny neurons (MSNs) of basal ganglia. Transcriptional perturbations synaptic genes neuroinflammation key processes that precede MSN dysfunction motor symptom onset. Understanding interplay between these crucial to develop effective therapeutic...
OBJECTIVE Traumatic brain injury (TBI) and hemorrhage are responsible for the largest proportion of all trauma-related deaths. In polytrauma patients at risk TBI, diagnosis, prognosis, management TBI remain poorly characterized. The authors sought to characterize predictive capabilities glial fibrillary acidic protein (GFAP) ubiquitin C-terminal hydrolase L1 (UCH-L1) measurements in with hemorrhagic shock without concomitant TBI. METHODS performed a secondary analysis on serial blood samples...
Introduction Huntington’s disease (HD) is a neurodegenerative that primarily affects the striatum, brain region controls movement and some forms of cognition. Neuronal dysfunction loss in HD accompanied by increased astrocyte density pathology. Astrocytes are heterogeneous population classified into multiple subtypes depending on expression different gene markers. Studying whether mutant Huntingtin (HTT) alters specific astrocytes necessary to understand their relative contribution HD....
p53 and HSF1 are two major transcription factors involved in cell proliferation apoptosis, whose dysregulation contributes to cancer neurodegeneration. Contrary most cancers, is increased Huntington's disease (HD) other neurodegenerative diseases, while decreased. reciprocal regulation has been shown different contexts, but their connection neurodegeneration remains understudied. Using cellular animal models of HD, we show that mutant HTT stabilized by abrogating the interaction between E3...
PSD-95 (Dlg4) is an ionotropic glutamate receptor scaffolding protein essential in synapse stability and neurotransmission. levels are reduced during aging neurodegenerative diseases like Huntington’s disease (HD), it believed to contribute synaptic dysfunction behavioral deficits. However, the mechanism responsible for dysregulation under these conditions unknown. The Heat Shock transcription Factor 1 (HSF1), canonically known its role homeostasis, also depleted both HD. Synaptic levels,...
Striatal medium spiny neurons are highly susceptible in Huntington's disease (HD), resulting progressive synaptic perturbations that lead to neuronal dysfunction and death. Non-invasive imaging techniques, such as proton magnetic resonance spectroscopy (
Abstract The BH3-only family of proteins is key for initiating apoptosis in a variety contexts, and may also contribute to non-apoptotic cellular processes. Historically, the nematode Caenorhabditis elegans has provided powerful system studying identifying conserved regulators proteins. In C. elegans, protein egl-1 expressed during development cell-autonomously trigger most developmental cell deaths. Here we provide evidence that transcribed after sensory neuron pair URX without inducing...
Heat shock factor 1 (HSF1) is abnormally degraded in Huntington's disease (HD): HD a neurodegenerative disorder characterized by severe cognitive and motor impairments. caused CAG repeat expansion within exon of the huntingtin (HTT) gene (The Disease Collaborative Research Group, 1993). These expansions lead to production an aberrant mutant protein (mHTT) that prone misfolding aggregation. Expression aggregation mHTT present virtually all cell types body but preferentially affects medium...
Abstract Background Huntington’s Disease (HD) is a neurodegenerative disorder caused by CAG trinucleotide repeat expansion in the HTT gene for which no therapies are available. This mutation causes protein misfolding and aggregation, preferentially affecting medium spiny neurons (MSNs) of basal ganglia. Transcriptional perturbations synaptic genes neuroinflammation key processes that precede MSN dysfunction motor symptom onset. Understanding interplay between these crucial to develop...
PSD-95 (Dlg4) is an ionotropic glutamate receptor scaffolding protein essential in synapse stability and neurotransmission. levels are reduced during aging neurodegenerative diseases like Huntington’s disease (HD), it believed to contribute synaptic dysfunction behavioral deficits. However, the mechanism responsible for dysregulation under these conditions unknown. The Heat Shock transcription Factor 1 (HSF1), canonically known its role homeostasis, also depleted both HD. Synaptic...
Abstract Striatal medium spiny neurons are highly susceptible in Huntington’s disease (HD), resulting progressive synaptic perturbations that lead to neuronal dysfunction and death. Non-invasive imaging techniques, such as proton magnetic resonance spectroscopy ( 1 H-MRS), used HD mouse models patients with monitor neurochemical changes associated health. However, the association between brain alterations dysregulation is unknown, limiting our ability potential treatments may affect synapse...
ABSTRACT The BH3-only family of proteins is key for initiating apoptosis in a variety contexts, and may also contribute to non-apoptotic cellular processes. Historically, the nematode Caenorhabditis elegans has provided powerful system studying identifying conserved regulators proteins. In C. , protein EGL-1 expressed during development cell-autonomously trigger most developmental cell deaths. Here we provide evidence that egl-1 transcribed after sensory neuron pair URX without inducing...
Summary p53 and HSF1 are two major transcription factors involved in cell proliferation apoptosis, whose dysregulation contributes to cancer neurodegeneration. Contrary cancer, is increased Huntington’s disease (HD) other neurodegenerative diseases, while decreased. Reciprocal regulation between was shown different contexts, but their connection neurodegeneration remained unexplored. Using cellular animal models of HD, we showed that mutant HTT stabilized by abrogating the interaction...
Abstract Huntington’s disease (HD) is a devastating neurodegenerative that primarily affects the striatum, brain region controls movement and some forms of cognition. Dysfunction loss medium spiny neurons striatum accompanied by astrogliosis (increased astrocyte density pathology). For decades, astrocytes were considered homogeneous cell type, but recent transcriptomic analyses revealed are heterogeneous population classified into multiple subtypes depending on expression different gene...