A5091868989- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Advanced Chemical Sensor Technologies
- Neural dynamics and brain function
- Higher Education Learning Practices
- Neuroendocrine regulation and behavior
- Biochemical Analysis and Sensing Techniques
- Engineering Education and Curriculum Development
- Neurological disorders and treatments
- MicroRNA in disease regulation
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Machine Fault Diagnosis Techniques
- Biomedical and Engineering Education
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Anomaly Detection Techniques and Applications
- Circadian rhythm and melatonin
- Engineering Diagnostics and Reliability
- Vestibular and auditory disorders
- Fire Detection and Safety Systems
Nanjing Medical University
2021-2025
Xuzhou Medical College
2018-2022
In awake rodents, the neural representation of olfactory information in bulb is largely dependent on brain state and behavioral context. Learning-modified plasticity has been observed mitral/tufted cells, main output neurons bulb. Here, we propose that odor encoded by cell responses mice highly task demands. We used fiber photometry to record calcium signals from population awake, head-fixed male under different found showed similar two distinct odors when were presented context a go/go...
Parvalbumin-positive (PV +) interneuron dysfunction is believed to be linked autism spectrum disorder (ASD), a neurodevelopmental disorder, characterized by social deficits and stereotypical behaviors. However, the underlying mechanisms of PV + remain largely unclear. Here, we found that deficiency biorientation defective 1 ( Bod1) in led an ASD-like phenotype Pvalb-Cre; Bod1 f/f mice. Mechanistically, identified induced hypoactivity hyperactivity calcium/calmodulin-dependent protein kinase...
Abstract Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific manipulations, we discovered novel GABAergic Purkinje cell (PC) circuit cerebellar IV/V lobe that projected to CaMKIIα + neurons fastigial nucleus (FN), which regulated sensorimotor coordination. Furthermore, transcriptomics profiling analysis revealed various neuronal...
Genetically distinct GABAergic interneuron subtypes play diverse roles in cortical circuits. Previous studies revealed that microRNAs (miRNAs) are differentially expressed subtypes, and essential for the normal migration, maturation, survival of medial ganglionic eminence-derived subtypes. How miRNAs function vasoactive intestinal peptide expressing (VIP+) interneurons derived from caudal eminence remains elusive. Here, we conditionally removed Dicer postmitotic VIP+ to block miRNA...
Abstract Aim MicroRNAs (miRNAs) are abundantly expressed in vasoactive intestinal peptide expressing (VIP + ) interneurons and indispensable for their functional maintenance survival. Here, we blocked miRNA biogenesis postmitotic VIP mice by selectively ablating Dicer, an enzyme essential maturation, to study whether ablation of affects olfactory function neural activity centres such as the bulb, which contains a large number interneurons. Methods A go/no‐go odour discrimination task...
Cognitive dysfunction stands as a prevalent and consequential non-motor manifestation in Parkinson's disease (PD). Although of the olfactory system has been recognized an important predictor cognitive decline, exact mechanism by which aberrant circuits contribute to PD is unclear. Here, we provide first evidence for abnormal functional connectivity across bulb (OB) piriform cortex (PC) or entorhinal (EC) clinical fMRI, neural coherence mice. Moreover, discovered that 2 subpopulations...
Severe anorexia limits the clinical application of cisplatin, and even leads to discontinuation treatment. However, mechanisms underlying cisplatin-induced are unknown. Herein, we demonstrated that cisplatin could affect neuronal gamma oscillations induce abnormal theta-gamma phase-amplitude coupling in arcuate nucleus (Arc) hypothalamus, these findings were associated with significantly decreased food intake weight loss mice. Chemogenetic activation AgRP neurons Arc reversed reduction We...
Disturbance of the cholinergic system plays a crucial role in pathological progression neurological diseases that cause dyskinesia-like behaviors. However, molecular mechanisms underlying this disturbance remain elusive. Here, we showed cyclin-dependent kinase 5 (Cdk5) was reduced neurons midbrain according to single-nucleus RNA sequencing analysis. Serum levels CDK5 also decreased patients with Parkinson's disease accompanied by motor symptoms. Moreover, Cdk5 deficiency triggered paw...
Automobile fire accidents are easy to cause difficulty in rescue and large losses due their rapid fire, fierce combustion spreading area. This article aims design a multi-stage early warning system for automobile engine compartment which collects characteristic parameters real time, triggers based on the recognized stages. paper analyzes requirements, conducts research from overall plan, hardware software.
In recent years, auto insurance fraud has shown an obvious growth trend. This brings huge economic losses to companies. The causes of accidents can be accurately reproduced by collecting objective quantitative information road conditions, environment and vehicle itself, conducting rigorous theoretical analysis calculation. Taking the identification a car collision accident as example, this article introduces how carry out identify authenticity accident. Through technical identification, is...