A5003718434- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Autophagy in Disease and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Bone Metabolism and Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Redox biology and oxidative stress
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Nitric Oxide and Endothelin Effects
- Orthopedic Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- Plant Molecular Biology Research
- Colorectal Cancer Screening and Detection
- Alcohol Consumption and Health Effects
- Cancer Genomics and Diagnostics
- Kruppel-like factors research
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Interference and Gene Delivery
Shanghai Jiao Tong University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Shandong University
2022
Nanjing University
2015-2016
State Key Laboratory of Pharmaceutical Biotechnology
2016
Nanjing General Hospital of Nanjing Military Command
2015
Wear particle-induced osteolysis is the leading cause of aseptic loosening, which most common reason for THA (total hip arthroplasty) failure and revision surgery. Although existing studies suggest that osteoblast apoptosis induced by wear debris involved in underlying mechanism linking particles to remains almost totally unknown. In present study, we investigated effect autophagy on CoCrMo metal (CoPs) vitro a calvarial resorption animal model. Our study demonstrated CoPs stimulated...
The regulation of glycometabolism homeostasis is vital to maintain health and development animal humans; however, the molecular mechanisms by which organisms regulate glucose metabolism from a feeding state switching non-feeding are not fully understood. Using holometabolous lepidopteran insect Helicoverpa armigera , cotton bollworm, as model, we revealed that steroid hormone 20-hydroxyecdysone (20E) upregulated expression transcription factor Krüppel-like (identified Klf15 ) promote...
Macrophages produce a large volume of ROS (reactive oxygen species) through respiratory burst. However, the influence iNOS [inducible NOS (nitric oxide synthase)] activation on production remains unclear. In present study, kinetic generation in RAW264.7 murine macrophages was monitored by chemiluminescence. PMA induces robust chemiluminescence cells, suggesting PKC (protein kinase C)-related assembly and NOX (NADPH oxidase). The effects induction were examined. Induction expression cells...
Abstract Background To explore the clinical prognostic utility of preoperative cholesterol-to-lymphocyte ratio (CLR) in outcomes for colorectal cancer liver metastasis (CRLM) patients receiving simultaneous resection primary lesion and metastases. Methods A total 444 CRLM resections were enrolled. The optimal cut-off value CLR was determined using highest Youden’s index. Patients divided into < 3.06 group CLR≥3.06 group. Propensity score matching analysis (PSM) inverse probability...