A5064908204- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Insect Resistance and Genetics
- Plant biochemistry and biosynthesis
- Lipid metabolism and biosynthesis
- Insect Utilization and Effects
- Kruppel-like factors research
- Plant Molecular Biology Research
Shandong University
2022-2025
Shandong Agricultural University
2025
The regulation of glycometabolism homeostasis is vital to maintain health and development animal humans; however, the molecular mechanisms by which organisms regulate glucose metabolism from a feeding state switching non-feeding are not fully understood. Using holometabolous lepidopteran insect Helicoverpa armigera , cotton bollworm, as model, we revealed that steroid hormone 20-hydroxyecdysone (20E) upregulated expression transcription factor Krüppel-like (identified Klf15 ) promote...
Highlights:•The fat body undergoes lipophagy during insect metamorphosis.•The steroid hormone 20E upregulates Akh and Akhr expression.•The AKH pathway increases hemolymph glucose levels by promoting gluconeogenesis.•High promote FOXO acetylation nuclear localization to induce gene expression of lipophagy.AbstractLipophagy is a way degrade lipids; however, the molecular mechanisms are not fully understood. Using holometabolous lepidopteran Helicoverpa armigera, cotton bollworm, as model, we...
The eukaryotic translation initiation factor 4E binding protein (4EBP) represses as a nonphosphorylated form by interacting with the (eIF4E). However, upstream regulator of 4EBP is unclear. Using major agricultural pest, Helicoverpa armigera, cotton bollworm, research model, we observed higher expression levels 4Ebp at 5th instar molting stage and metamorphosis. 20-hydroxyecdysone (20E) significantly upregulated inhibited its phosphorylation. 20E promoted ecdysone receptor B (EcRB) to...
Amino acid metabolism is regulated according to nutrient conditions; however, the mechanism not fully understood. Using holometabolous insect cotton bollworm (Helicoverpa armigera) as a model, we report that hemolymph metabolites are greatly changed from feeding larvae wandering and pupae. Arginine, alpha-ketoglutarate (α-KG), glutamate (Glu) identified marker of larvae, pupae, respectively. Arginine level decreased by 20-hydroxyecdysone (20E) regulation via repression argininosuccinate...
Holometabolous insects undergo morphological remodeling from larvae to pupae and adults with typical changes in the cuticle; however, mechanism is unclear. Using lepidopteran agricultural insect Helicoverpa armigera , cotton bollworm, as a model, we revealed that transcription factor RUNT-like (encoded by Runt-like ) regulates development of pupal cuticle via promoting protein gene ( HaPcp expression. The was highly expressed epidermis wing during metamorphosis found being involved RNA...