A5101445412- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Parvovirus B19 Infection Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Reproductive Health and Technologies
- Ovarian function and disorders
- Genomic variations and chromosomal abnormalities
- Blood groups and transfusion
- Microfluidic and Bio-sensing Technologies
- Endometriosis Research and Treatment
- Preterm Birth and Chorioamnionitis
- Pediatric Urology and Nephrology Studies
- Single-cell and spatial transcriptomics
- COVID-19 and healthcare impacts
- Chemokine receptors and signaling
- Ectopic Pregnancy Diagnosis and Management
- Gynecological conditions and treatments
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Congenital heart defects research
- Phytoestrogen effects and research
Tongji University
2022-2025
Zhongnan Hospital of Wuhan University
2016-2025
Wuhan University
2016-2025
Wuhan Medical Center for Women and Children
2022
Shanghai Tenth People's Hospital
2022
Peking University
2020
Wuhan Institute of Virology
2020
Northwestern University
2020
Peking University First Hospital
2020
Xintai People's Hospital
2018
Developing a minimally invasive, real-time diagnostic tool to accurately assess endometrial conditions is critical increasing pregnancy rates in assisted reproductive technology (ART). In this research, fiberoptic bronchoscopy and optical coherence tomography (OCT) were used before after alcohol injury human chorionic gonadotropin (hCG)-induced pseudopregnancy monitor changes the rabbit endometrium. Histological analysis electron microscopy performed on 1 cm uterine sections while...
Cell-free DNA has been widely used in non-invasive prenatal diagnostics (NIPD) nowadays. Compared to these incomplete and multi-source fragments, fetal nucleated red blood cells (fNRBCs), once as an aided biomarker monitor potential pathological conditions, have re-attracted research interest NIPD because of their definite source the total genetic information contained nuclei. Isolating from maternal peripheral subsequent cell-based bio-analysis make maximal diagnosis possible, while causing...
Fetal nucleated red blood cells (fNRBCs) in maternal peripheral containing the whole genetic information of fetus may serve for noninvasive pregnant diagnostics (NIPD). However, fetal cell-based NIPD is seriously limited by poor purity isolated fNRBCs. Recently, biomimetic cell membrane-camouflaged nanoparticles outstanding features have been widely used to detect and isolate rare from samples. In this work, enythrocyte (RBC) leukocyte (WBC) membranes are fused coated onto magnet then...
Aberrant subchondral bone architecture is a crucial driver of the pathological progression osteoarthritis, coupled with increased sensory innervation. The PGE2/EP4 pathway involved in regulation mass accrual by induction differentiation mesenchymal stromal cells. This study aimed to clarify whether induces aberrant structural alteration osteoarthritis. Destabilization medial meniscus (DMM) using mouse model was combined three approaches: treatment celecoxib, capsaicin, and nerve-specific...
Abstract Objective The primary object of this study is to analyze chromosomal abnormalities in miscarriages detected by copy number variants sequencing (CNV-Seq), establish potential pathways or genes related miscarriages, and provide guidance for birth health the following pregnancies. Methods This enrolled 580 miscarriage cases with paired clinical information detection results analyzed CNV-Seq. Further bioinformatic analyses were performed on validated pathogenic CNVs (pCNVs). Results Of...
Non-invasive prenatal diagnostics (NIPD) has been an emerging field for diagnosis research. Carrying the whole genome coding of fetus, fetal nucleated red blood cells (FNRBCs) have pursued as a surrogate biomarker traveling around in maternal blood. Here, by combining unique microbead-based centrifugal separation and enzymatic release, we demonstrated novel method FNRBC isolation from samples. First, gelatin-coated silica microbeads were modified with FNRBC-specific antibody (anti-CD147) to...
Diminished ovarian reserve (DOR) is a common cause of female infertility, with genetic factors being significant contributor. However, due to high heterogeneity, the etiology DOR in many cases remains unknown. In this study, we analyzed phenotype young woman primary infertility and performed molecular analysis identify her condition, thus providing important insights for counseling reproductive guidance.We collected patient's basic information, clinical data, as well diagnostic therapeutic...
Massively parallel sequencing (MPS) technology has become increasingly available and been widely used to screen for trisomies 21, 18, 13 in singleton pregnancies. This study assessed the performance of MPS testing cell-free fetal DNA (cffDNA) from maternal plasma twin Ninety-two women with pregnancies were recruited. The results identified through karyotypes amniocentesis or clinical examination follow-up neonates. Fluorescent in-situ hybridization was examine placentas postnatally cases...
Fetal nucleated red blood cells (fNRBCs) in the peripheral of pregnant women contain comprehensive fetal genetic information, making them an ideal target for non-invasive prenatal diagnosis (NIPD). However, challenges identifying, enriching, and detecting fNRBCs limit their diagnostic potential. To overcome these obstacles, we developed a novel biomimetic chip, replicating micro-nano structure rose petals on polydimethylsiloxane (PDMS). The surface was modified with gelatin nanoparticles...
ABO hemolytic disease of the newborn (ABO-HDN), which may cause neonatal jaundice and polycythemia, or even stillbirth death, is widespread in China. Prenatal testing for fetal blood group can reduce unnecessary concerns ensure prompt treatment. Herein, we presented a method to employ high-density silica microbeads (SiO2 MBs) capturing nucleated red cells (fnRBCs) maternal peripheral blood, detected genotype fetus using these captured cells. We evaluated 52 patients SiO2 MBs. Among 26...
We hereby reported the diagnosis, treatment process and perinatal outcome of a patient with novel coronavirus infection in period. The pregnant woman delivered boy by cesarean section at 37+2 gestational weeks due to severe liver dysfunction. She subsequently had high fever 2 days later, was confirmed nucleic acid test throat swab. After 12-day isolation support treatment, her two consecutive swab results for turned negative she discharged. tested patient's blood, urine, breast milk as well...