A5100375219- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Nuclear Receptors and Signaling
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Bone Tissue Engineering Materials
- Parkinson's Disease Mechanisms and Treatments
- Dialysis and Renal Disease Management
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Aquaculture disease management and microbiota
- Virus-based gene therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biochemical and Molecular Research
- Hepatitis B Virus Studies
- Endometriosis Research and Treatment
- Autoimmune Bullous Skin Diseases
- Reproductive tract infections research
- Central Venous Catheters and Hemodialysis
- Gene Regulatory Network Analysis
Peking University
2012-2025
University of Electronic Science and Technology of China
2025
Mianyang Central Hospital
2025
Children's Hospital of Chongqing Medical University
2022-2025
Chongqing Medical University
2022-2025
Peking University People's Hospital
2012-2025
Chinese Academy of Agricultural Sciences
2005-2024
Tobacco Research Institute
2020-2024
Jinan University
2024
Shaanxi University of Chinese Medicine
2024
PI3K/AKT signaling is known to regulate cancer metabolism, but whether metabolic feedback regulates the pathway unclear. Here, we demonstrate important reciprocal crosstalk between signal and pentose phosphate (PPP) branching pathways. activation stabilizes G6PD, rate-limiting enzyme of PPP, by inhibiting newly identified E3 ligase TIRM21 promotes PPP. PPP metabolites, in turn, reinforce AKT further promote reprogramming blocking expression inhibitor PHLDA3. Knockout TRIM21 or PHLDA3 cell...
Abstract Chronic stress induces anxiety disorders via both neural pathways and circulating factors. Although many studies have elucidated the circuits involved in stress-coping behaviors, origin regulatory mechanism of peripheral cytokines behavioural regulation under conditions are not fully understood. Here, we identified a serum cytokine, lipocalin 2 (LCN2), that was upregulated participants with disorders. Using mouse model chronic restraint (CRS), LCN2 found to be related stress-induced...
Heterosis is a biological phenomenon whereby the offspring from two parents show improved and superior performance than either inbred parental lines. Hybrid rice one of most successful apotheoses in crops utilizing heterosis. Transcriptional profiling F1 super-hybrid Liangyou-2186 its by serial analysis gene expression (SAGE) revealed 1183 differentially expressed genes (DGs), among which DGs were found significantly enriched pathways such as photosynthesis carbon-fixation, key involved...
We screened LRRK2 mutations in exon 41 904 parkin-negative Parkinson's disease (PD) patients (868 probands) from 18 countries across 5 continents. found three heterozygous missense (novel I2012T, G2019S, and I2020T) 41. identified 11 (1.3%) among 868 PD probands, including 2 sporadic cases 8 (6.2%) of 130 autosomal dominant families. The exhibited relatively common worldwide distribution. Among the 41, it has been reported that Caucasian with G2019S mutation have a single-founder effect. In...
This study aimed to investigate the contribution of interleukin (IL)-10-producing regulatory B cells (B10 cells) pathogenesis PNS. The percentages B10 cells, CD19+CD24hiCD27+ CD19+CD24hiCD38hi CD19+CD24hiCD27+IL-10+ CD19+CD24hiCD38hiIL-10+ Th17 and T (Treg) within peripheral blood mononuclear (PBMCs) from healthy subjects PNS patients with active disease or in remission were analysed by flow cytometry. IL-10 production circulating two subsets decreased children returned normal levels...
Myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immune from the myeloid lineage, play an important part in suppression host responses during many pathologic conditions, including cancer and infectious diseases. Thus, understanding functional diversity these as well underlying mechanisms is crucial for development disease control strategies. The role MDSCs Schistosoma japonicum infection, however, not clear, there lack systematic study so far. In this study, we provide...
Antimicrobial peptides (AMPs) are a class of templates with application potential for drug development. Amphibians important sources AMPs. Duttaphrynus melanostictus is the main source traditional Chinese medicine "Chansu", which has anti-infection effect while without clear mechanism. This study aimed to find cathelicidin peptide in D. and then investigate activity vivo vitro, an AMP-encoding gene (cathelicidin-DM, GenBank: KJ820824.1) was obtained from constructed cDNA library...
Abstract Background Mineral and bone disorder (MBD) in patients with chronic kidney disease is associated increased morbidity mortality. Studies regarding the status of MBD treatment developing countries, especially Chinese dialysis are extremely limited. Methods A cross-sectional study 1711 haemodialysis (HD) 363 peritoneal (PD) were enrolled. Parameters related to MBD, including serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH) analyzed. The achievement targets was...
Leukemia stem cells (LSCs) are regarded as the origins and key therapeutic targets of leukemia, but limited knowledge is available on determinants LSC ‘stemness’. Using single-cell RNA-seq analysis, we identify a master regulator, SPI1, LSC-specific expression which determines molecular signature activity LSCs in murine Pten-null T-ALL model. Although initiated by PTEN-controlled β-catenin activation, Spi1 ‘stemness’ maintained β-catenin-SPI1-HAVCR2 regulatory circuit independent...
Fungi have been proved as promising and prolific sources of functional secondary metabolites with potent agricultural applications. In this study, 14 xanthone derivatives (1–14), including six new ones, versicones I–N (1–4, 7, 11), a biogenetically related derivative (15), were isolated from the alga-derived fungus Aspergillus versicolor D5. Their structures elucidated by comprehensive spectroscopic methods. Versicone L (4) exhibited broad antifungal spectrum prominent inhibitory effects on...
Five new sorbicillinoid derivatives, including (±)-aspersorbicillin A [(±)-
The dysfunction of natural killer (NK) cells has been widely reported in malignancies, including solid tumours. Gastric cancer mesenchymal stem (GCMSCs) are one the vital elements stromal tumour environment (TME) which possess immunosuppressive activity. This study aimed to determine whether GCMSCs involved inhibition NK cell immune function and explore its underlying mechanism.CD107a perforin expression conditioned medium (GCMSCs-CM)-primed were detected by flow cytometry. To cytotoxicity,...
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy often associated with poor outcomes. To identify high-risk factors and potential actionable targets for T-ALL, we perform integrated genomic transcriptomic analyses on samples from 165 Chinese pediatric adult T-ALL patients, of whom 85% have outcome information. The mutation landscape this cohort very similar to the Western published previously, except that rate
CD11c is a canonical dendritic cell (DC) marker with poorly defined functions in the immune system. Here, we found that blocking on human peripheral blood mononuclear cell-derived DCs (MoDCs) inhibited proliferation of CD4+ T cells and differentiation into IFN-γ-producing helper 1 (Th1) cells, which were critical acute graft-versus-host disease (aGVHD) pathogenesis. Using allogeneic bone marrow transplantation (allo-BMT) murine models, consistently CD11c-deficient recipient mice had...