A5102946197- Endometriosis Research and Treatment
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- MicroRNA in disease regulation
- Rheumatoid Arthritis Research and Therapies
- Gynecological conditions and treatments
- Biosimilars and Bioanalytical Methods
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Vitamin D Research Studies
- Hypothalamic control of reproductive hormones
- Tuberculosis Research and Epidemiology
- Protein Tyrosine Phosphatases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
Zhongnan Hospital of Wuhan University
2009-2024
Wuhan University
2009-2024
Hubei Provincial Women and Children's Hospital
2024
In the past several months, outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated infection (coronavirus disease 2019 [COVID-19]) developed rapidly and has turned into a global pandemic. Although SARS-CoV-2 mainly attacks systems, manifestations multiple organs have been observed. A great concern was raised about whether COVID-19 may affect male reproductive functions. this study, we collected semen specimens from 12 patients for virus detection characteristics...
Abstract Since SARS-CoV-2 infection was first identified in December 2019, it spread rapidly and a global pandemic of COVID-19 has occurred. ACE2, the receptor for entry into target cells by SARS-CoV-2, found to abundantly express testes, including spermatogonia, Leydig Sertoli cells. However, there is no clinical evidence about whether can affect male gonadal function so far. In this study, we compared sex-related hormones between 81 reproductive-aged men with 100 age-matched healthy men,...
KN012 is a proposed biosimilar candidate for the reference drug denosumab, with brand name Prolia®. This study explored tolerance, variability, and pharmacokinetics (PK) of denosumab its in healthy Chinese subjects.A randomized, double-blind, parallel, two-arm was performed to analyze bioequivalence (60 mg) compared denosumab.The PK properties were similar those denosumab. When geometric mean ratios (GMRs) Cmax, AUC0-t, AUC0-∞ 98.74%, 102.54%, 102.18%, respectively, 90% confidence interval...
Background: Histone lactylation is crucial in a variety of physiopathological processes, however, the function and mechanism histone endometriosis remain poorly understood. Therefore, objective this investigation was to illuminate endometriosis. Methods: Immunohistochemistry used investigate expression lactylation. Cell Counting Kit-8 assay (CCK8), Transwell mouse models were effects vitro vivo. Transcriptomics Immunoprecipitation-Mass Spectrometry (IP-MS), Western Blot,...
Abstract Endometrial basal layer is essential for the endometrial regeneration, whose disruption leads to thin endometrium or intrauterine adhesion (IUA) with unsatisfactory prognosis. Emerging data indicate that platelet-rich plasma (PRP) can promote proliferation, but mechanism by which PRP regulates regeneration remains unclear. Herein, we investigated therapeutic effects and possible mechanisms of on regeneration. IUA animal model was generated sham, mechanically damaging without 10...
Objective KN015 is a long-acting, recombinant human follicle-stimulating hormone Fc fusion protein that induces follicle development. This first-in-human study evaluated the effect of on healthy, pituitary-suppressed women and examined its pharmacokinetics, pharmacodynamics, tolerability.Methods phase I was double-blind, randomized, placebo-controlled design with single ascending dose (20, 40, 60 μg, respectively).Results After subcutaneous administration dose, maximum serum concentrations...