A5101923362- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical studies and practices
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Immunodeficiency and Autoimmune Disorders
- Blood Pressure and Hypertension Studies
- Adrenal Hormones and Disorders
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Receptor Mechanisms and Effects
- Health Systems, Economic Evaluations, Quality of Life
- Legume Nitrogen Fixing Symbiosis
- Receptor Mechanisms and Signaling
- Nephrotoxicity and Medicinal Plants
- Functional Brain Connectivity Studies
- Veterinary medicine and infectious diseases
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Insurance, Mortality, Demography, Risk Management
- Nanoparticles: synthesis and applications
- Analytical Methods in Pharmaceuticals
- Psoriasis: Treatment and Pathogenesis
- Liver Disease Diagnosis and Treatment
Southwest University
2025
First Hospital of Jilin University
2013-2024
State Key Laboratory of Vehicle NVH and Safety Technology
2024
Jilin University
2013-2024
Beijing Normal University
2024
University of Electronic Science and Technology of China
2024
The Fourth People's Hospital
2023-2024
Hainan Agricultural School
2023
Baoshan College
2022
Guang’anmen Hospital
2022
KEA4, KEA5, and KEA6 are members of the Arabidopsis (Arabidopsis thaliana) K+ efflux antiporter (KEA) family that share high sequence similarity but whose function remains unknown. Here, we show their gene expression pattern, subcellular localization, physiological in Arabidopsis. had similar tissue patterns, three KEA proteins localized to Golgi, trans-Golgi network, prevacuolar compartment/multivesicular bodies, suggesting overlapping roles these endomembrane system. Phenotypic analyses...
Abstract Shading in combination with extended photoperiods can cause exaggerated stem elongation (ESE) soybean, leading to lodging and reduced yields when planted at high-density high-latitude regions. However, the genetic basis of plant height adaptation these regions remains unclear. Here, through a genome-wide association study, we identify regulating gene on chromosome 13 ( PH13 ) encoding WD40 protein three main haplotypes natural populations. We find that an insertion Ty1/Copia -like...
Abstract Background The intricate relationship between hypertension and chronic kidney disease (CKD) presents a global challenge for prevention of hypertension-related CKD. This study’s objective is to analyze age, gender, regional disparities, evolving trends in the burden We aim estimate changing spatial temporal incidence mortality rates, considering socio-demographic index (SDI), inform health strategies effectively. Method Age-standardized rates (ASIR) death (ASDR) were collected from...
Background: Donafenib is a novel compound similar to sorafenib that functions as multikinase inhibitor. This phase 1b trial aimed assess the safety, pharmacokinetics and efficacy of donafenib in treating Chinese patients with advanced hepatocellular carcinoma. Methods: From July 2014 April 2015, 27 eligible carcinoma were enrolled trial. They randomly divided into 200 mg 300 bid groups received these oral doses until appearance intolerance or disease progression. Results: Overall, was safe...
Water tends to wet all hydrophilic surfaces under ambient conditions, and the first water adlayers on solids are important for a broad range of physicochemical phenomena technological processes, including corrosion, wetting, lubrication, anti-icing, catalysis, electrochemistry. Unfortunately, challenges in characterizing adlayer laboratory have hampered molecular-level understanding contact structure. Herein, we present ab initio molecular dynamics simulation evidence previously unreported...
This study was conducted to explore the tolerance, variability, pharmacokinetics (PK), and pharmacodynamics (PD) of denosumab biosimilar (QL1206) in healthy Chinese subjects.This is a randomized, double-blind, two-arm, parallel performed examine bioequivalence biosimilar, QL1206, with that Xgeva® (Denosumab) as reference drug. A single dose 120 mg/kg or administered subjects, who were followed up for 134 days.Similar PK properties those exhibited by QL1206. When compared QL1206 Xgeva®, 90%...
The primary objective of this study was to investigate if hepatic impairment alters the safety, pharmacokinetics, and pharmacodynamics HSK3486.This a clinical trial HSK3486 in subjects with normal function (n = 8), mild (Child-Pugh A; n or moderate B; 8) impairment. Each subject received an IV bolus dose 0.4 mg/kg for 1 min, immediately followed by maintenance infusion mg/kg/h 30 min.In total, 24 were enrolled completed study. generally well tolerated all subjects. There no serious AEs...
Objective: The study aimed to explore the bioequivalence of a proposed biosimilar BAT1806 its reference products marketed in EU and US (RoActemra-EU Actemra-US) among healthy Chinese men. tolerance, immunogenicity, pharmacokinetics (PK) three drugs were also investigated. Methods: In this randomized, double-blind, single-dose, three-arm, parallel study, single-dose 4 mg/kg products, or was administered participants. participants followed up for 57 days, PK, tolerance evaluations completed...
Psoriasis is a chronic, immune-mediated skin disease with an unmet need for biologic treatment options. To assess the safety, pharmacokinetics, and efficacy of QX004N in healthy individuals patients moderate to severe plaque psoriasis China. This randomized clinical trial was composed 2 parts. Part 1 first-in-human, single-ascending-dose, phase 1a conducted from November 2, 2021, January 16, 2023. double-blind, multiple dose-escalation, 1b February 15, 2023, 5, 2024, at 5 centers China,...
ABSTRACT Background and Aims Freethiadine is a novel hepatitis B virus capsid assembly modulator. Herein, we report the safety, tolerability, pharmacokinetics 28‐day antiviral activities of freethiadine. Methods The study consisted two parts. Part 1 involved single‐ascending‐dose, multiple‐ascending‐dose food effect study. 2 was double‐blind, double‐dummy, randomised, entecavir‐controlled, multi‐dose escalation in chronic (CHB) patients. Results A total 88 healthy subjects 40 patients with...
To compare the pharmacokinetic (PK) profiles, immunogenicity, and safety of proposed biosimilar IBI305 with those bevacizumab in healthy male subjects.A phase I, randomized, double-blinded, two-arm, parallel-group study.The study was conducted The First Hospital Jilin University, Changchun, China, from March 2017 to November 2017.A total 100 subjects were enrolled, 48 group 50 included final analysis.In a 16-week course, participants randomized at 1:1 ratio receive intravenous administration...
KN012 is a proposed biosimilar candidate for the reference drug denosumab, with brand name Prolia®. This study explored tolerance, variability, and pharmacokinetics (PK) of denosumab its in healthy Chinese subjects.A randomized, double-blind, parallel, two-arm was performed to analyze bioequivalence (60 mg) compared denosumab.The PK properties were similar those denosumab. When geometric mean ratios (GMRs) Cmax, AUC0-t, AUC0-∞ 98.74%, 102.54%, 102.18%, respectively, 90% confidence interval...
Objectives: The study aimed to explore the bioequivalence of a proposed biosimilar HL02 vs. its reference products (US-trastuzumab) among healthy Chinese men.Methods: In this study, nine male subjects received single ascending doses trastuzumab (HL02, 2–8 mg/kg), and then randomized, double-blind, two-arm, parallel was conducted investigate PK similarity (6 mg/kg) with that US-trastuzumab as drug.Results: properties exhibited by (N = 55) were similar those 52). comparison biosimilarity...
Purpose QX003S is a biosimilar candidate for the reference tocilizumab, Actemra®. We investigated tolerance, variability, and pharmacokinetics (PK) of in healthy Chinese male subjects.Design A randomised, double-blind, two-arm, parallel study was performed to examine bioequivalence (8 mg/kg) with that Actemra® as drug.Results (N = 40) groups exhibited similar PK properties. The inter-subject variability ranged from 14.95% 18.78%. 90% confidence intervals ratios Cmax, AUC0–t andAUC0–∞ both...
Abstract Purpose To compare the pharmacokinetic profiles, safety and immunogenicity of proposed bevacizumab biosimilar HLX04 with reference in healthy Chinese males. Methods In this double-blind Phase 1 study, volunteers ( N = 208) were randomized 1:1:1:1 to a single 3 mg/kg intravenous infusion or sourced from United States (bevacizumab-US), European Union (bevacizumab-EU) China (bevacizumab-CN). Co-primary endpoints area under serum concentration–time profile (AUC) time zero extrapolated...
We compared the pharmacokinetic (PK) profiles of diethylstilbestrol orally dissolving film (DES ODF) and DES-capsule as well assessing safety, local tolerability, taste, disintegration time DES ODF.Twelve healthy male volunteers receiving a single administration 2.0 mg ODF or were included in study. The to dissolution assessed after dosing. Safety assessments adverse events, hematology biochemistry tests, urinalysis, vital signs, electrocardiography.The PK parameters all greater than those...
Objective: To evaluate the tolerance, variability, and pharmacokinetics (PK) of QX001S, a biosimilar for ustekinumab, in healthy Chinese men. Methods: One hundred seventy-eight men were recruited this randomized, double-blind, single-dose, two-arm, parallel study, received 45 mg QX001S or ustekinumab single subcutaneous injection. PK, immunogenicity, tolerance evaluated all participants period 113°days. Results: The similarity between two drugs was determined by comparing baseline...
ABSTACT A rapid and sensitive liquid chromatography–tandem mass spectrometric method to evaluate the permeation retention of calcipotriol in excised samples pig, rat mouse skin after application a ointment has been developed validated. After sample preparation ointment, homogenate receptor medium by liquid–liquid extraction, chromatography was performed on an Extend‐C 18 column using isocratic elution. Detection electrospray ionization negative ion mode multiple‐reaction monitoring precursor...