A5101796781- Adipokines, Inflammation, and Metabolic Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Gastric Cancer Management and Outcomes
- Alcohol Consumption and Health Effects
- Pharmacological Effects of Natural Compounds
- Cancer-related Molecular Pathways
- Pain Mechanisms and Treatments
- Ovarian cancer diagnosis and treatment
- Selenium in Biological Systems
- Advanced Breast Cancer Therapies
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Biosimilars and Bioanalytical Methods
- Genomics, phytochemicals, and oxidative stress
- Maternal and Perinatal Health Interventions
- Pharmacological Receptor Mechanisms and Effects
- Corneal surgery and disorders
- Cancer Mechanisms and Therapy
- IL-33, ST2, and ILC Pathways
- Traditional Chinese Medicine Studies
- Gallbladder and Bile Duct Disorders
- Maternal and fetal healthcare
- Trace Elements in Health
University of South China
2020-2024
Maastricht University
2023
Geneeskundige en Gezondheidsdienst
2023
Maastricht University Medical Centre
2020-2022
First Affiliated Hospital of Zhengzhou University
2022
Air Force Medical University
2013-2017
Xuzhou Medical College
2017
Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, we examined mechanism underlying effect PCB-153 on glucose and lipid metabolism in vivo vitro. We found induced per se worsened high fat diet (HFD)-resulted increase blood level insulin intolerance. addition, HFD-resulted triglyceride content adipose mass. Moreover, concentration-dependently inhibited insulin-dependent uptake accumulation...
This study aims to explore the mechanism of Yangxuerongjin pill (YXRJP) in treatment diabetic peripheral neuropathy (DPN) by network pharmacology and metabolomics technology combined with animal experiments, provide scientific basis for DPN. In this study, analysis was applied identify active compounds, core targets signal pathways, which might be responsible effect The DPN model established high-fat diet streptozotocin (STZ) injection, rats were given administration 12 weeks. body weight,...
Alcoholic liver disease (ALD) has become an important hazard to public and personal health. Oxidative stress is believed be responsible for the pathological changes in ALD. Previous studies have showed that insulin, a classic regulator of glucose metabolism, significant anti-oxidative function plays role maintaining redox balance. For addressing effects mechanisms insulin pre-administration on ethanol-induced oxidative injury, we investigated histopathology, inflammatory factors, apoptosis,...
Abstract The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycation endproducts (AGEs). MGO and AGEs are increased subjects with diabetes associated fatal nonfatal cardiovascular disease. Previously, we have shown that plasma concentrations rapidly increase postprandial phase, higher individuals type 2 diabetes. In current study, investigated whether tissues originates from exogenous glucose concentration leads to fast MGO-derived AGEs. We...
To analyze the clinical epidemiological characteristics of patients with gallbladder carcinoma recruited from 17 hospitals in five northwestern provinces China (Shaanxi Province, Gansu Qinghai Ningxia Hui Autonomous Region, and Xinjiang Uygur Region) 2009 to 2013, summarize diagnosis treatment data carcinoma.Clinical information 2379 was retrospectively collected analyzed using "Questionnaire for Gallbladder Carcinoma Patients Northwestern Area China." All verified EpiData software SPSS 13.0...
Abstract Purpose: Tumour metabolism has become a novel factor targeted by personalised cancer drugs. This research evaluated the prognostic significance of metabolism-related genes (MRGs) in ovarian serous cystadenocarcinoma (OSC). Methods: MRGs 379 women surviving OSC were obtained using The Cancer Genome Atlas (TCGA) database. Then, several biomedical computational algorithms employed to identify eight hub that significantly relevant survival. These have important clinical and value OSC....
Nicotine withdrawal (NTW) has been shown to increase pain sensitivity. However, the pathogenesis of NTW-induced hyperalgesia syndrome is unknown. Microglial activation, with increased expression P2X4 receptor (P2X4R) and brain-derived neurotrophic factor (BDNF) as important markers, associated hyperalgesia; therefore, these markers may represent an unprecedented target prevent hyperalgesia. In this study, we explored contributions spinal microglial P2X4R-BDNF signaling in Immunohistochemical...
Abstract Purpose To compare the pharmacokinetic profiles, safety and immunogenicity of proposed bevacizumab biosimilar HLX04 with reference in healthy Chinese males. Methods In this double-blind Phase 1 study, volunteers ( N = 208) were randomized 1:1:1:1 to a single 3 mg/kg intravenous infusion or sourced from United States (bevacizumab-US), European Union (bevacizumab-EU) China (bevacizumab-CN). Co-primary endpoints area under serum concentration–time profile (AUC) time zero extrapolated...
Background Uterine rupture is a serious obstetric emergency, severe event, and threat to maternal fetal life. It rare not well characterized by the fact that multiple operations of uterine cavities contribute during pregnancy. Atypical easily misdiagnosed as other or surgical diseases. In current guidelines, abdominocentesis contraindication for late Therefore, cases presented in this report provide new ideas clinical diagnosis treatment rupture. Case summary 1, 34-year-old woman (gravida 5,...
Abstract Purpose: To investigate the differences between 0.2% and 0.15% brimonidine tartrate eye drops for anti-mydriatic effects optical quality under different light conditions. Methods This prospective study involved 50 consecutive high myopia patients undergoing implantation of a V4c ICL. was administered into right eye, left 1 month postoperatively. Visual (measured by analysis system), pupil center, size refraction conditions were measured before 0.5h after administration. A symptom...