A5100654182- Neonatal Respiratory Health Research
- Renal and related cancers
- Medical Imaging Techniques and Applications
- Liver physiology and pathology
- Skin Protection and Aging
- Congenital Diaphragmatic Hernia Studies
- Reproductive Biology and Fertility
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Aldose Reductase and Taurine
- Cancer-related Molecular Pathways
- Heavy Metals in Plants
- FOXO transcription factor regulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- dental development and anomalies
- Cancer Mechanisms and Therapy
- COVID-19 Clinical Research Studies
- Hedgehog Signaling Pathway Studies
- Cholinesterase and Neurodegenerative Diseases
- Eicosanoids and Hypertension Pharmacology
- Surgical site infection prevention
- Gestational Diabetes Research and Management
- Birth, Development, and Health
Nanjing Medical University
2025
Nanjing Maternity and Child Health Care Hospital
2021-2025
Cornell University
2023-2024
Stony Brook University
2023-2024
Southern Medical University
2024
Weill Cornell Medicine
2023
Guilin Medical University
2023
Nanchong Central Hospital
2022
North Sichuan Medical University
2022
Wuhan University
2020-2022
Vascular endothelial growth factor (VEGF) was expressed in developing respiratory epithelial cells under control of the promoter from human surfactant protein C (SP-C) gene. SP-C-VEGF transgenic mice did not survive after birth. When obtained by hysterectomy on embryonic day 15 (E15) or 17 (E17), abnormalities were confined to lung and correlated with expression transgene mRNA as revealed situ hybridization. On E15 E17, marked morphogenesis observed mice. Lungs consisted large dilated...
The development of endochondral bones requires the coordination signals from several cell types within cartilage rudiment. A signaling cascade involving Indian hedgehog (Ihh) and parathyroid hormone related peptide (PTHrP) has been described in which hypertrophic differentiation is limited by a signal secreted chondrocytes as they become committed to hypertrophy. In this negative-feedback loop, Ihh inhibits regulating expression Pthrp, turn acts directly on growth plate that express...
Members of the transforming growth factor beta (TGF-beta) family polypeptides have been implicated in morphogenesis and differentiation numerous tissues, including lung. In order to further define effects TGF-beta signaling lung morphogenesis, a constitutively active form TGF-beta1 was expressed respiratory epithelial cells fetal mouse vivo. Expression arrested pseudoglandular stage development, inhibiting synthesis differentiation-dependent proteins, SP-B, SP-C, CCSP, maintaining embryonic...
Previous studies have reported that metformin (MET) has anticancer activity. In combination with chemotherapeutic drugs, MET reduces the dosage of drugs required and enhances efficacy. present study, paclitaxel (PTX) in three human prostate cancer (PCa) cell lines (22RV1, PC‑3 LNCaP) was evaluated to investigate effects on proliferation apoptosis PCa cells. The study explored whether their were associated reactive oxygen species (ROS). An MTT assay microscopy used effect + PTX growth. Half...
Many epidemiological studies have shown that anovulatory polycystic ovary syndrome (PCOS) is accompanied by hyperandrogenism. However, the exact mechanism of hyperandrogen-induced anovulation remains to be elucidated. In this study, we aimed investigate potential in PCOS. To role klotho as a key factor androgen receptor (AR)-mediated development PCOS, investigated effects testosterone on ovarian expression vivo and vitro.Testosterone propionate (TP)-induced rats showed cycle irregularity,...
Molecular detection of HBV has a significant impact on prognosis and therapy the disease. In this paper, sensitive nucleic acid method was established taking advantage magnetic nanoparticles (MNPs), chemiluminescence (CL) polymerase chain reaction (PCR). HBV-DNA extracted from hepatitis B positive human blood samples using MNPs adsorption biotin labeled DNA segment after base insertion bintin-dUTP in PCR. The biotinylated captured by amino probe immobilized carboxyl detected system alkaline...
Microvascular loss is one of the most important characteristics skin aging and several microvascular activities play key roles in preserving health. In vitro, lycopene (Ly) reduced contents reactive oxygen species (ROS), β-galactosidase, advanced glycosylation end products (AGEs), while increasing ATP NAD+/NADH along with mitochondrial membrane potential (MMP). Furthermore, expression Fibrillin-I VEGF was increased aged primary fibroblast cells (PRSFs). LC-MS non-targeted cell metabolomics...
Thyroid transcription factor-1 (TITF-1) is a homeodomain containing factor that binds to and selectively activates the expression of genes in thyroid pulmonary epithelial cells. TITF-1 plays critical role gene organogenesis lung thyroid. In present work, epitope-tagged proteins were used identify regions polypeptide mediate nuclear localization transcriptional activity human adenocarcinoma A series TITF-1-flag deletion mutants was generated transfected into H441 cells determine amino acid...
Abstract Purpose: Tumour metabolism has become a novel factor targeted by personalised cancer drugs. This research evaluated the prognostic significance of metabolism-related genes (MRGs) in ovarian serous cystadenocarcinoma (OSC). Methods: MRGs 379 women surviving OSC were obtained using The Cancer Genome Atlas (TCGA) database. Then, several biomedical computational algorithms employed to identify eight hub that significantly relevant survival. These have important clinical and value OSC....
Background . Multiple interleukin (IL) family members were reported to be closely related hypertension. We aimed investigate whether IL-9 affects angiotensin II- (Ang II-) induced hypertension in mice. Methods Mice treated with Ang II, and expression was determined. In addition, effects of knockout (KO) on blood pressure observed II-infused To determine the mediated by signal transducer activator transcription 3 (STAT3) pathway, II-treated mice given S31-201. Furthermore, circulating levels...
This study was the first to investigate synthesis of near-infrared light-sensitive NO prodrug [Mn(PaPy2Q)(NO)]ClO4, and detection amount released by drug in different time near infrared light (10 mW, 20 mW). It showed that with increase power, required for release shortened, we selected 10 min as a follow-up power irradiation while ensuring did not affect tumor cells. The cells were irradiated mW at 6 h after treatment on PC-3, LNCaP 22RV1 cells, concentration cell survival rate tested 12 h,...
Accurate PET quantification of tracer uptake in small brain structures is confounded by low sensitivity and partial volume effect (PVE) caused the limited spatial resolution. To overcome these limitations, we proposed Prism-PET scanner which employs TOF-DOI capable single-ended detector blocks arranged compact conformal decagon geometry to stimulatingly achieve ultra-high resolution high sensitivity. Previously, have developed a DOI-rebinning method for that repositions DOI-based...