A5077896863- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Sedative Agents
- Pharmacogenetics and Drug Metabolism
- Receptor Mechanisms and Signaling
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Traffic and Road Safety
- Epilepsy research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Receptor Mechanisms and Effects
- Microtubule and mitosis dynamics
- Pneumonia and Respiratory Infections
- Diet and metabolism studies
- Cardiac tumors and thrombi
- Hormonal Regulation and Hypertension
- Urban Transport and Accessibility
- Cardiac Ischemia and Reperfusion
- Neuropeptides and Animal Physiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes Treatment and Management
- Hemodynamic Monitoring and Therapy
- 3D Printing in Biomedical Research
- Computational Drug Discovery Methods
- Antibiotic Resistance in Bacteria
- Older Adults Driving Studies
First Hospital of China Medical University
2025
China Medical University
2025
Qiqihar Medical University
2024
University of Iowa
2020-2024
China National Pharmaceutical Group Corporation (China)
2021-2023
Translational Therapeutics (United States)
2020-2022
Jilin University
2017-2021
First Hospital of Jilin University
2017-2021
Guizhou Botanical Garden
2021
University of California, Davis
2020
The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects chromosome biology and are critical for genomic stability. In eukaryotes, six Smc form three heterodimers--Smc1/3, Smc2/4, Smc5/6--which together with non-Smc cohesin, condensin, the Smc5/6 complex, respectively. Cohesin is required proper segregation. It establishes maintains sister-chromatid cohesion until sister chromatids achieve bipolar attachment to mitotic spindle. Condensin mediates condensation...
DNA double-strand breaks (DSBs) fuel cancer-driving chromosome translocations. Two related structural maintenance of chromosomes (Smc) complexes, cohesin and Smc5/6, promote DSB repair through sister chromatid homologous recombination (SCR). Here we show that the Smc5/6 subunit Mms21 sumoylates multiple lysines Scc1. promotes cohesin-dependent small ubiquitin-like modifier (SUMO) accumulation at laser-induced damage sites in S/G2 human cells. Cells expressing nonsumoylatable Scc1 mutant...
Background: The present clinical trial investigated the potential influences of dosage and age on pharmacokinetic properties safety profile HSK3486, whether any adjustment in dosing regimen is necessary elderly patients. Methods: Twenty-four participants (65–73 years) were apportioned to three equal cohorts receive a single IV bolus 0.2, 0.3, 0.4 mg/kg respectively. An additional control group comprised eight non-elderly (21–44 years), who each received dose mg/kg. Safety was assessed...
This study provides a national profile of occupational fatalities among truck drivers and driver-sales workers.Data from the 2003-2008 Census Fatal Occupational Injuries were used. Cases extracted specifically for subcategories included in Driver/Sales Workers Truck Drivers category: Workers, Heavy Tractor-Trailer Drivers, Light or Delivery Services Drivers.In 2003-2008, group had 5,568 fatalities, representing 17% all United States. The majority these subgroup (85%) due to transportation...
Objectives: Piperacillin, a β-lactam antibiotic, and tazobactam, β-lactamase inhibitor, combine to offer broad antibacterial coverage with low toxicity. This combination is first-line treatment for severe infections in critically ill patients. Given the significant pharmacokinetic (PK) variability caused by complex pathophysiological changes patients, identifying effective dosing regimens of piperacillin-tazobactam this special population imperative [1]. To address clinical need, study aims...
Translesion synthesis (TLS) enables DNA replication through damaged bases, increases cellular damage tolerance, and maintains genomic stability. The sliding clamp PCNA the adaptor polymerase Rev1 coordinate switching during TLS. polymerases Pol η, ι, κ insert nucleotides opposite bases. ζ, consisting of catalytic subunit Rev3 regulatory Rev7, then extends past lesion. Here, we show that Rev7 binds to transcription factor TFII-I in human cells. is required for TLS tolerance. function appears...
Dexmedetomidine (DEX) has been hypothesized to possess anti-oxidative properties that may mitigate the damage caused by ischemia-reperfusion (IR) injury. The aim of present study was examine effects DEX on intestinal contractile activity, inflammation and apoptosis following IR Intestinal injury induced in rats complete occlusion superior mesenteric artery for 60 min, followed a 60-min reperfusion period. Rats received an intraperitoneal injection 25 µg/kg at 30 min prior Following...
Oxaliplatin (OXA) is a third-generation, platinum-based anticancer agent that reported to induce cell toxicity in normal cells, which severely limits its applications. Its instability aqua solution plays an important role the cytotoxic effects. In this study, two novel drug–drug cocrystals of OXA were synthesized using baicalein (BAI) and naringenin (NAR) as cocrystal formers, well characterized by single crystal X-ray diffraction, powder Fourier transform-infrared spectroscopy, thermal...
In the present study, population pharmacokinetic (PK) analysis was performed based on meropenem data from a prospective study conducted in 114 critically ill patients with wide range of renal functions and various disease conditions. The final model one-compartment linear elimination, creatinine clearance continuous replacement therapy affecting clearance, total bodyweight impacting volume distribution. Our is valuable addition to existing PK models, it could be particularly useful during...
Background: Ciprofol, a novel sedative-hypnotic drug, has been approved for its use in inducing and maintaining general anesthesia, as well providing sedation. Methods: In this phase I, single-center, parallel, controlled, open-label clinical trial, our objective was to analyze the pharmacokinetics (PK), pharmacodynamics (PD), safety of ciprofol emulsion 24 participants with mild moderate renal impairment (n = 8 per group) matched healthy 8). An initial loading infusion administered at 0.4...
The United States of America is fighting against one its worst-ever drug crises. Over 900 people a week die from opioid- or heroin-related overdoses, while millions more suffer opioid prescription addiction. Recently, overdoses caused by fentanyl-laced cocaine specifically are on the rise. Due to synergy and an increase in side effects, polydrug addiction can cause risk than single drug. In present work, we systematically analyzed overdose mechanism fentanyl. First, applied our established...
The primary objective of this study was to investigate if hepatic impairment alters the safety, pharmacokinetics, and pharmacodynamics HSK3486.This a clinical trial HSK3486 in subjects with normal function (n = 8), mild (Child-Pugh A; n or moderate B; 8) impairment. Each subject received an IV bolus dose 0.4 mg/kg for 1 min, immediately followed by maintenance infusion mg/kg/h 30 min.In total, 24 were enrolled completed study. generally well tolerated all subjects. There no serious AEs...
Abstract Captagon, known by its genetic name Fenethylline, is an addictive drug that complicates the War on Drugs. Captagon has a strong CNS stimulating effect than primary metabolite, Amphetamine. However, multi-targets issues associated with and metabolites as well underlying mechanisms have not been fully defined. In present work, we applied our established drug-abuse chemogenomics-knowledgebase systems pharmacology approach to conduct targets/off-targets mapping (SP-Targets)...
In the current study, population pharmacokinetic (PK) of ampicillin-sulbactam was performed based on clinical pharmacokinetics data collected from a prospective study conducted in 40 surgical patients undergoing prolonged surgery where antibiotic redosing implemented. A PK model successfully developed to characterize disposition ampicillin and sulbactam. The final models were two-compartment for both drugs, with creatinine clearance heart failure affecting body surface area having an impact...
Autotaxin (ATX) and lysophosphatidic acid (LPA) play an important role in pathogenesis of idiopathic pulmonary fibrosis (IPF). FTP-198 is oral, novel selective ATX inhibitor indicated for treating IPF. The study aimed to investigate the pharmacokinetics, pharmacodynamics, safety tolerability healthy subjects. A single-center, randomized, double-blind, placebo-controlled, single ascending-dose Phase I was performed. Pharmacokinetics, food effect on elimination, were evaluated. total 30...