A5058052139- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Orthopedic Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hematological disorders and diagnostics
- Cystic Fibrosis Research Advances
- Influenza Virus Research Studies
- Bacterial biofilms and quorum sensing
- Congenital Diaphragmatic Hernia Studies
- Streptococcal Infections and Treatments
- Neonatal Respiratory Health Research
- Emergency and Acute Care Studies
- Hemodynamic Monitoring and Therapy
- Poisoning and overdose treatments
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Pharmacological Effects and Toxicity Studies
- Animal Virus Infections Studies
- COVID-19 and Mental Health
- Bacterial Genetics and Biotechnology
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
Vanderbilt University Medical Center
2020-2025
Institut de Recherche Vaccinale
2023-2024
Medical College of Wisconsin
2014-2015
Abstract Administrative databases are powerful tools for pediatric research but lack patient‐level microbiology results. This study aimed to determine the accuracy of pathogen discharge diagnosis codes children hospitalized with acute hematogenous musculoskeletal infections (MSKIs). Medical records 244 MSKIs were manually reviewed which bacterial pathogen, if any, was identified each MSKI based on results obtained during hospitalization. Microbiology patient then compared their diagnoses in...
Objectives: Piperacillin, a β-lactam antibiotic, and tazobactam, β-lactamase inhibitor, combine to offer broad antibacterial coverage with low toxicity. This combination is first-line treatment for severe infections in critically ill patients. Given the significant pharmacokinetic (PK) variability caused by complex pathophysiological changes patients, identifying effective dosing regimens of piperacillin-tazobactam this special population imperative [1]. To address clinical need, study aims...
Abstract Background Hybrid immunity is associated with more durable protection against coronavirus disease 2019 (COVID-19). We describe the antibody responses following severe acute respiratory syndrome 2 (SARS-CoV-2) infection in vaccinated and unvaccinated individuals. Methods The 55 vaccine arm COVID-19 cases diagnosed during blinded phase of Coronavirus Efficacy trial were matched placebo cases. Pseudovirus neutralizing (nAb) activity to ancestral strain binding (bAb) nucleocapsid spike...
In the present study, population pharmacokinetic (PK) analysis was performed based on meropenem data from a prospective study conducted in 114 critically ill patients with wide range of renal functions and various disease conditions. The final model one-compartment linear elimination, creatinine clearance continuous replacement therapy affecting clearance, total bodyweight impacting volume distribution. Our is valuable addition to existing PK models, it could be particularly useful during...
BACKGROUND AND OBJECTIVES Acute hematogenous musculoskeletal infections (MSKI) are medical emergencies with the potential for life-altering complications in afflicted children. Leveraging administrative data to study pediatric MSKI is difficult as many chronic, nonhematogenous, or occur children significant comorbidities. The objective of this was validate a case-finding algorithm accurately identify hospitalized acute using billing codes. METHODS This multicenter validation Pediatric Health...
We aimed to identify rational empirical dosing strategies for cefepime treatment in critically ill patients by utilizing population pharmacokinetics and target attainment analysis.
Abstract Background The disease burden of influenza‐associated hospitalizations among children in Jordan is not well established. We aimed to characterize attributed influenza a pediatric population. Methods conducted cross‐sectional study from our viral surveillance cohort under 2 years hospitalized with acute respiratory symptoms and/or fever March 2010 2013. collected demographic and clinical characteristics, calculated the frequency who met severe illness (SARI) criteria. Nasal specimens...
Patients with cystic fibrosis (CF) experience recurrent bacterial pulmonary exacerbations. Management of these infections is increasingly challenging due to decreased antimicrobial susceptibility β-lactam antibiotics. The pharmacokinetics (PK) agents are inadequately characterized in patients CF. This study enrolled 155 pediatric and adult participants CF who were receiving the following antibiotics: cefepime (n = 82), meropenem 42), or piperacillin-tazobactam 31). Opportunistic blood...
Abstract Background Dosing guidelines of cefepime are well defined in healthy pediatric and adult populations but have not been extensively studied critically ill patients. Patients who may significant alterations antibiotic pharmacokinetics (PK) pharmacodynamics (PD) due to many factors. Receipt ECMO or CRRT further alter PK/PD changes clearance volume distribution the depletion plasma proteins. Since patients likely receive multiple courses antimicrobials, optimization drug dosing delivery...
Abstract Determining an effective dosing regimen for piperacillin–tazobactam in critically ill patients is challenging due to substantial pharmacokinetic variability caused by complex pathophysiological changes. To address this need, a prospective clinical study was conducted, which enrolled 112 and employed opportunistic sampling strategy. Population modeling simulation were performed characterize the pharmacokinetics (PK) probability of target attainment (PTA) under various regimens. Both...
Respiratory syncytial virus (RSV) is a major cause of respiratory disease in infants, making vaccination an attractive preventive strategy. Due to earlier reports vaccine-enhanced RSV-naive children, assessing prior RSV infection critical for determining eligibility future infant vaccine trials. However, this complicated by the presence maternally transferred maternal antibodies. We sought develop assays that measure immune responses pre-fusion (F) protein discriminates between and...
Abstract Background Patients with cystic fibrosis (CF) experience recurrent bacterial pulmonary exacerbations. The management of these infections becomes increasingly complex due to decreased antimicrobial susceptibility and inadequate pharmacokinetic/pharmacodynamic (PK/PD) characterization the most commonly used agents in this population. Methods One hundred fifty-five pediatric adult participants receiving cefepime (n=82), meropenem (n=42), or piperacillin-tazobactam (n=31) were enrolled....
Abstract Background Surgical biopsy and drainage may have diagnostic therapeutic benefits for children with acute hematogenous osteomyelitis (AHO). However, it remains unknown whether routinely expediting surgical procedures improves clinical outcomes compared to a “wait-and-see” approach. We aimed determine hospitals that frequently perform early surgery AHO improved rarely surgery. Methods Admissions at 48 were identified in the Pediatric Health Information System from 1/2015 through...
Abstract Background RSV is a major cause of pediatric respiratory disease. Antibodies to the prefusion conformation fusion (pre-F) protein are needed for virus neutralization. Method We measured RSV-specific responses in two groups children <3 years age; subjects with laboratory-confirmed (RSV-infected) or infants born period May September and enrolled prior their first season (RSV-uninfected). RSV-infected had blood samples obtained at 1, 6, 9, 12 months after infection....
Abstract Background Patients with cystic fibrosis (CF) experience recurrent bacterial pulmonary exacerbations. The management of these infections becomes increasingly complex due to decreased antimicrobial susceptibility and inadequate pharmacokinetic/pharmacodynamic (PK/PD) characterization the most commonly used agents in this population. Methods One hundred fifty-five pediatric adult participants receiving cefepime (n=82), meropenem (n=42), or piperacillin-tazobactam (n=31) were enrolled....
Abstract Background RSV is a major cause of pediatric respiratory disease. Antibodies to the prefusion conformation fusion (pre-F) protein are needed for virus neutralization. Methods We measured RSV-specific responses in two groups children < 3 years age; subjects with laboratory-confirmed (RSV-infected) or infants born period May September and enrolled prior their first season (RSV-uninfected). RSV-infected had blood samples obtained at 1, 6, 9, 12 months after infection....